Age
Item
age of 18 years and older.
boolean
C0001779 (UMLS CUI [1])
Myeloid Leukemia, Chronic
Item
chronic myeloid leukemia (cml)
boolean
C0023473 (UMLS CUI [1])
Previous treatment with imatinib and the development of progressive disease
Item
previous treatment with imatinib at a dose of >600 mg/day and the development of progressive disease while receiving imatinib at that dose, or
boolean
C2114510 (UMLS CUI [1,1])
C0935989 (UMLS CUI [1,2])
C1335499 (UMLS CUI [2,1])
C0935989 (UMLS CUI [2,2])
Resistance to imatinib caused of bcr-abl gene mutation
Item
cml with resistance to imatinib at a dose less than or equal to 600 mg/day with genetic mutation in the bcr-abl gene that is associated with a high level of resistance to imatinib, or
boolean
C0013203 (UMLS CUI [1,1])
C1835417 (UMLS CUI [1,2])
C0935989 (UMLS CUI [1,3])
Intolerance to imatinib
Item
intolerance to imatinib at any dose
boolean
C0277585 (UMLS CUI [1,1])
C0935989 (UMLS CUI [1,2])
Adequate organ function
Item
adequate organ function
boolean
C0678852 (UMLS CUI [1])
Negative pregnancy test and using of adequate contraception methods
Item
women who are able to bear children must have a negative serum or urine pregnancy test. adequate methods of contraception must be used throughout the study to avoid pregnancy for the entire interval of at least 1 month before and 3 months after completion of the study medication.
boolean
C0427780 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Pregnancy or breast-feeding
Item
woman who are pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Sexual partners are women with childbearing potential, who are unwilling/unable to use contraception methods
Item
men whose sexual partners are women who are of childbearing potential, and who are unwilling or unable to use an acceptable method to avoid pregnancy of his partner for the entire study period as outlined above
boolean
C0036911 (UMLS CUI [1,1])
C3831118 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
Medical history of accelerated phase or blast crisis cml
Item
previous diagnosis of accelerated phase or blast crisis cml.
boolean
C0262926 (UMLS CUI [1,1])
C0023472 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0919644 (UMLS CUI [2,2])
Eligible and willing to undergo transplantation
Item
participants who are eligible and willing to undergo transplantation during the screening period
boolean
C1504389 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
Uncontrolled or significant cardiovascular disease
Item
uncontrolled or significant cardiovascular disease
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Concomitant medication with imatinib within 7 days
Item
use of imatinib within 7 days.
boolean
C2826666 (UMLS CUI [1,1])
C0935989 (UMLS CUI [1,2])
C3843296 (UMLS CUI [1,3])
Concomitant medication with interferon or cytarabine within 14 days
Item
use of interferon or cytarabine within 14 days
boolean
C2826666 (UMLS CUI [1,1])
C0021747 (UMLS CUI [1,2])
C4288440 (UMLS CUI [1,3])
C2826666 (UMLS CUI [2,1])
C0010711 (UMLS CUI [2,2])
C4288440 (UMLS CUI [2,3])
Concomitant medication with anticancer agents within 14 days
Item
use of a targeted small-molecule anticancer agent within 14 days
boolean
C2826666 (UMLS CUI [1,1])
C0003392 (UMLS CUI [1,2])
C4288440 (UMLS CUI [1,3])
Concomitant Medication that carry a side effect risk of torsade de pointes, inhibit platelet function or anticoagulants
Item
use of certain medication that carry a known side effect risk of torsade de pointes- certain medications that irreversibly inhibit platelet function or anticoagulants
boolean
C2826666 (UMLS CUI [1,1])
C0879626 (UMLS CUI [1,2])
C0040479 (UMLS CUI [1,3])
C2826666 (UMLS CUI [2,1])
C3463820 (UMLS CUI [2,2])
C1254881 (UMLS CUI [2,3])
C2826666 (UMLS CUI [3,1])
C3463820 (UMLS CUI [3,2])
C0003280 (UMLS CUI [3,3])
Prior therapy with dasatinib
Item
prior therapy with dasatinib.
boolean
C1514463 (UMLS CUI [1,1])
C1455147 (UMLS CUI [1,2])