Age
Item
age 18-75
boolean
C0001779 (UMLS CUI [1])
Insulin-Dependent Diabetes Mellitus disease length
Item
type 1 diabetes (who definition) of at least 5 years duration
boolean
C0011854 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Loss of hypoglycemic warning | Capillary blood glucose measurement Quantity | Symptoms Absent
Item
history of impaired awareness of hypoglycaemia (capillary glucose readings < 3.5mmol/l without symptoms on > 3 occasions in the past 3 months (those with intact symptoms will be unlikely to show an improvement and would not really benefit from taking any medication intended just to increase symptoms)
boolean
C0342317 (UMLS CUI [1])
C0457578 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1457887 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
Systemic disease Severe
Item
severe systemic illness
boolean
C0442893 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Malignant Neoplasms
Item
active malignancy
boolean
C0006826 (UMLS CUI [1])
Complications of Diabetes Mellitus Severe | Severe visual impairment | Renal Insufficiency Severe | Autonomic neuropathy Symptomatic Severe
Item
severe complications of diabetes such as severe visual impairment, severe renal impairment, severe symptomatic autonomic neuropathy
boolean
C0342257 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1301509 (UMLS CUI [2])
C1565489 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0259749 (UMLS CUI [4,1])
C0231220 (UMLS CUI [4,2])
C0205082 (UMLS CUI [4,3])
Myocardial Ischemia untreated | Cerebrovascular accident
Item
untreated ischemic heart disease, recent stroke
boolean
C0151744 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0038454 (UMLS CUI [2])
Lactose Intolerance | Placebo Containing Lactose
Item
lactose intolerance ( the placebo will contain lactose)
boolean
C0022951 (UMLS CUI [1])
C1696465 (UMLS CUI [2,1])
C0332256 (UMLS CUI [2,2])
C0022949 (UMLS CUI [2,3])
Diabetes mellitus poor control Very | Glycosylated hemoglobin A | Liver disease | Alanine aminotransferase increased | Aspartate aminotransferase increased
Item
very poor diabetes control (hba1c > 10%) liver disease ( increase in alt / ast > 3x uln)
boolean
C0860161 (UMLS CUI [1,1])
C0442824 (UMLS CUI [1,2])
C0019018 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0151905 (UMLS CUI [4])
C0151904 (UMLS CUI [5])
Chronic Kidney Disease Stage | Estimated Glomerular Filtration Rate
Item
chronic kidney disease stage 4 or 5 ( egfr < 30ml/min)
boolean
C1561643 (UMLS CUI [1,1])
C2074731 (UMLS CUI [1,2])
C3811844 (UMLS CUI [2])
Hypothyroidism Severe untreated | Adrenal gland hypofunction Severe untreated
Item
severe untreated thyroid or adrenal insufficiency ( must be treated and on stable doses for at least 6 weeks)
boolean
C0020676 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])
C0001623 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0332155 (UMLS CUI [2,3])