Schizophrenia
Item
schizophrenia
boolean
C0036341 (UMLS CUI [1])
Study Subject Participation Status Inclusion
Item
participants will be included if they:
boolean
C2348568 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Voluntary participation | Competence Consent
Item
1. are voluntary and competent to consent;
boolean
C0680274 (UMLS CUI [1])
C0086035 (UMLS CUI [2,1])
C1511481 (UMLS CUI [2,2])
Schizophrenia | Schizoaffective Disorder
Item
2. have a diagnosis of schizophrenia or schizoaffective disorder as confirmed by the structure clinical interview for the dsm-iv (scid-iv)
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
Positive and negative symptoms persistent | Drug trial | Antipsychotic Agents
Item
3. have persistent positive and negative symptoms despite having trialled, or being currently medicated, with antipsychotic medication; and
boolean
C0871099 (UMLS CUI [1,1])
C0205322 (UMLS CUI [1,2])
C0304229 (UMLS CUI [2])
C0040615 (UMLS CUI [3])
Age
Item
4. are between the ages of 18 and 65.
boolean
C0001779 (UMLS CUI [1])
Pharmaceutical Preparations
Item
concomitant medications including:
boolean
C0013227 (UMLS CUI [1])
Benzodiazepines
Item
1. benzodiazepines,
boolean
C0005064 (UMLS CUI [1])
Mood Stabilizers | Lithium | Valproic Acid
Item
2. mood stabilizers (lithium, valproic acid)
boolean
C4020582 (UMLS CUI [1])
C0023870 (UMLS CUI [2])
C0042291 (UMLS CUI [3])
Antidepressive Agents | Serotonin Uptake Inhibitors | Tricyclic Antidepressive Agents | Anticholinergic Agents | Carbamazepine Interferes with Anodal Transcranial Direct Current Stimulation Effects
Item
3. antidepressants (including serotonin reuptake inhibitors and tricyclic antidepressants) and anticholinergics will be allowed. since carbamazepine has been shown to interfere with the effects of anodal tdcs, potential participants taking it will not be suitable for inclusion in the trial.
boolean
C0003289 (UMLS CUI [1])
C0162758 (UMLS CUI [2])
C0003290 (UMLS CUI [3])
C0242896 (UMLS CUI [4])
C0006949 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C3850022 (UMLS CUI [5,3])
C1280500 (UMLS CUI [5,4])
Depressive disorder
Item
depression
boolean
C0011581 (UMLS CUI [1])
Study Subject Participation Status Inclusion
Item
participants will be included if they:
boolean
C2348568 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Competence Consent
Item
1. are competent to consent;
boolean
C0086035 (UMLS CUI [1,1])
C1511481 (UMLS CUI [1,2])
Major Depressive Disorder | Major depressive episode
Item
2. have a diagnosis of major depression and are currently experiencing a major depressive episode as confirmed by the structure clinical interview for the dsm-iv (scid-iv);
boolean
C1269683 (UMLS CUI [1])
C0024517 (UMLS CUI [2])
Treatment Resistant Disorders | Absent response to treatment | Intolerance to Antidepressive Agents Dose
Item
3. are treatment resistant, defined as a failure to achieve a clinical response, or an inability to tolerate, an antidepressant trial of sufficient dose for at least 6 weeks; and
boolean
C0871547 (UMLS CUI [1])
C0438286 (UMLS CUI [2])
C1744706 (UMLS CUI [3,1])
C0003289 (UMLS CUI [3,2])
C0178602 (UMLS CUI [3,3])
Age
Item
4. are between the ages of 18 and 75.
boolean
C0001779 (UMLS CUI [1])
Pharmaceutical Preparations
Item
concomitant medications including:
boolean
C0013227 (UMLS CUI [1])
Benzodiazepines
Item
1. benzodiazepines,
boolean
C0005064 (UMLS CUI [1])
Mood Stabilizers | Lithium | Valproic Acid
Item
2. mood stabilizers (lithium, valproic acid)
boolean
C4020582 (UMLS CUI [1])
C0023870 (UMLS CUI [2])
C0042291 (UMLS CUI [3])
Antidepressive Agents | Serotonin Uptake Inhibitors | Tricyclic Antidepressive Agents | Anticholinergic Agents | Carbamazepine Interferes with Anodal Transcranial Direct Current Stimulation Effects
Item
3. antidepressants (including serotonin reuptake inhibitors and tricyclic antidepressants) and anticholinergics will be allowed. since carbamazepine has been shown to interfere with the effects of anodal tdcs, potential participants taking it will not be suitable for inclusion in the trial.
boolean
C0003289 (UMLS CUI [1])
C0162758 (UMLS CUI [2])
C0003290 (UMLS CUI [3])
C0242896 (UMLS CUI [4])
C0006949 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C3850022 (UMLS CUI [5,3])
C1280500 (UMLS CUI [5,4])
Study Subject Participation Status Exclusion
Item
patients will be excluded if they:
boolean
C2348568 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Substance Use Disorders | Substance Dependence
Item
1. have a dsm-iv history of substance abuse or dependence in the last 6 months;
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Comorbidity Major Unstable | Nervous system disorder Major Unstable
Item
2. have a concomitant major and unstable medical or neurologic illness;
boolean
C0009488 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0443343 (UMLS CUI [1,3])
C0027765 (UMLS CUI [2,1])
C0205164 (UMLS CUI [2,2])
C0443343 (UMLS CUI [2,3])
Carbamazepine
Item
3. are currently taking carbamazepine; or,
boolean
C0006949 (UMLS CUI [1])
Pregnancy
Item
4. are pregnant.
boolean
C0032961 (UMLS CUI [1])
Patient withdrawn from trial
Item
patients will be withdrawn from the study if they:
boolean
C0422727 (UMLS CUI [1])
Consent Withdraw
Item
1. withdraw consent;
boolean
C1511481 (UMLS CUI [1,1])
C2349954 (UMLS CUI [1,2])
Deterioration Clinical Significance
Item
2. experience significant clinical deterioration;
boolean
C1279889 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
Therapeutic procedure Receive failed
Item
3. fail to tolerate the procedure; or,
boolean
C0087111 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C0231175 (UMLS CUI [1,3])
Adverse event Serious | Patient withdrawn from trial | Withdrawal by Subject | Interventional procedure Clinical | Interventional procedure Cognitive | Interventional procedure Neurophysiology
Item
4. develop a serious adverse event. in the event that a patient is withdrawn or drops out of the study, efforts will be made to obtain a final set of clinical, cognitive and neurophysiological measures at the time of withdrawal for a last observation carried forward analysis.
boolean
C0877248 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0422727 (UMLS CUI [2])
C1710677 (UMLS CUI [3])
C0184661 (UMLS CUI [4,1])
C0205210 (UMLS CUI [4,2])
C0184661 (UMLS CUI [5,1])
C1516691 (UMLS CUI [5,2])
C0184661 (UMLS CUI [6,1])
C0700630 (UMLS CUI [6,2])