Outpatients | Parkinson Disease
Item
1. outpatients with idiopathic pd according to the uk parkinson's disease society brain bank clinical diagnosis criteria.
boolean
C0029921 (UMLS CUI [1])
C0030567 (UMLS CUI [2])
Age
Item
2. age 30 years to 80 years.
boolean
C0001779 (UMLS CUI [1])
Dyskinesia Severity Minimum Abnormal Involuntary Movement Scale
Item
3. dyskinesias with a minimum severity equal to a rating of 10 or higher on the aims rating scale at baseline.
boolean
C0013384 (UMLS CUI [1,1])
C0439793 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C0450978 (UMLS CUI [1,4])
Dyskinesia disability Moderate UPDRS
Item
4. dyskinesias at least moderately disabling (historical information from item 33 of updrs).
boolean
C4034322 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C3639721 (UMLS CUI [1,3])
Antiparkinson Agents Dose Stable
Item
5. stable dose of antiparkinsonian medication 4 weeks prior to study entry.
boolean
C0003405 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Childbearing Potential Contraceptive methods Pregnancy test negative
Item
6. women of child-bearing potential must use a reliable method of contraception and must be willing to perform a pregnancy test paid for and provided by dr. zesiewicz and the usf medical clinic. there must be a negative result before entry into the study.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0427780 (UMLS CUI [1,3])
Illness Study Subject Participation Status Exclusion | Disease Unstable | Parkinson Disease Intravenous infusion intolerant
Item
1. any illness that in the investigator's opinion preclude participation in this study. this includes patients with unstable disease and those pd patients who can not tolerate iv infusion.
boolean
C0221423 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C2828389 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0030567 (UMLS CUI [3,1])
C0021440 (UMLS CUI [3,2])
C0231200 (UMLS CUI [3,3])
Pregnancy | Breast Feeding | Pregnancy test positive
Item
2. pregnant or lactating women. pregnancy will not be allowed whether as a pre-existing condition or a positive result on the pregnancy test in the screening process. lactation includes any woman wanting to participate who is currently breast-feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0240802 (UMLS CUI [3])
Study Subject Participation Status Requirement Informed Consent
Item
3. patients may not be dual enrolled to another research study requiring the patient to sign informed consent.
boolean
C2348568 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
Dementia Preventing Informed Consent | Mental disorder Preventing Informed Consent | Mini-mental state examination
Item
4. dementia or other psychiatric illness that prevents the patient from giving informed consent (mini mental status exam score of less than 20).
boolean
C0497327 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
C0451306 (UMLS CUI [3])
Disability Legal | Legal capacity Limited
Item
5. legal incapacity or limited legal capacity.
boolean
C0231170 (UMLS CUI [1,1])
C1301860 (UMLS CUI [1,2])
C0683673 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
Kidney Disease Severe | Blood urea increased | Prostate specific antigen normal | Urodynamic studies normal | Serum creatinine raised
Item
6. presence of severe renal disease (bun 50% greater than normal). patients must have evidence from their pcp or urologists of normal psa and urodynamic tests within the last 12 months; patients with bun 50% greater than normal (5 to 20 mg/ d l) or creatinine 50% greater than normal (0 .7 and 1.4 mg/ d l) will be excluded. labs will be requested from pcp.
boolean
C0022658 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0151539 (UMLS CUI [2])
C0580554 (UMLS CUI [3])
C0580523 (UMLS CUI [4])
C0700225 (UMLS CUI [5])
Antipsychotic Agents Dose U/day | Metoclopramide Dose U/day | Domperidone Dose U/day | Azole antifungal High dose | Ketoconazole High dose | Etomidate High dose | Ciprofloxacin High dose | Fluvoxamine High dose | Cimetidine High dose | Fludrocortisone High dose | Encainide High dose | Flecainide High dose | Mexiletine High dose | Propafenone High dose | Guanoxan High dose | Maprotiline High dose | Antidepressive Agents High dose | Adrenal Cortex Hormones Oral
Item
7. concomitant or prior therapy with the following treatments: neuroleptics, metoclopramide, domperidone (in doses >60mg/day), azole antifungals (e.g. ketoonazole), etomidate, ciprofloxacin, fluvoxamine, cimetidine, fludrocortizone, encainide, flecainide, mexiletine, propafenone, guanoxane, maprotiline, antidepressants on doses higher than the maximum approved daily dose for outpatients, intermittent therapy with oral corticoids.
boolean
C0040615 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
C0025853 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0456683 (UMLS CUI [2,3])
C0013015 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0456683 (UMLS CUI [3,3])
C0360363 (UMLS CUI [4,1])
C0444956 (UMLS CUI [4,2])
C0022625 (UMLS CUI [5,1])
C0444956 (UMLS CUI [5,2])
C0015131 (UMLS CUI [6,1])
C0444956 (UMLS CUI [6,2])
C0008809 (UMLS CUI [7,1])
C0444956 (UMLS CUI [7,2])
C0085228 (UMLS CUI [8,1])
C0444956 (UMLS CUI [8,2])
C0008783 (UMLS CUI [9,1])
C0444956 (UMLS CUI [9,2])
C0016280 (UMLS CUI [10,1])
C0444956 (UMLS CUI [10,2])
C0085251 (UMLS CUI [11,1])
C0444956 (UMLS CUI [11,2])
C0016229 (UMLS CUI [12,1])
C0444956 (UMLS CUI [12,2])
C0025887 (UMLS CUI [13,1])
C0444956 (UMLS CUI [13,2])
C0033429 (UMLS CUI [14,1])
C0444956 (UMLS CUI [14,2])
C0650263 (UMLS CUI [15,1])
C0444956 (UMLS CUI [15,2])
C0024778 (UMLS CUI [16,1])
C0444956 (UMLS CUI [16,2])
C0003289 (UMLS CUI [17,1])
C0444956 (UMLS CUI [17,2])
C0001617 (UMLS CUI [18,1])
C1527415 (UMLS CUI [18,2])
Able to speak fluently English Language Lacking
Item
8. patients who are not fluent in english.
boolean
C0564241 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])