Acute lymphocytic leukemia | Leukemia, Myelocytic, Acute | Remission First Absent | Remission second Absent | Remission Induction Therapy failed | Recurrent disease
Item
patients with acute lymphocytic leukemia or acute myelogenous leukemia who are not in first or second remission (i.e., after failing remission induction therapy or in relapse or beyond second remission)
boolean
C0023449 (UMLS CUI [1])
C0023467 (UMLS CUI [2])
C0544452 (UMLS CUI [3,1])
C0205435 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C0544452 (UMLS CUI [4,1])
C0205436 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C1514832 (UMLS CUI [5,1])
C0231175 (UMLS CUI [5,2])
C0277556 (UMLS CUI [6])
Sibling HLA-A Identical | Sibling HLA-B Identical | Sibling HLA-C Identical | Sibling HLA-DR Identical | Sibling Donation of bone marrow Willing | Sibling Hematopoietic stem cells Primed | Unrelated Donors HLA Matched | ABO blood group Combination Donor Recipient
Item
all candidates for this study must have an hla (a, b, c, dr) identical sibling who is willing to donate bone marrow or primed blood stem cells or a 10/10 allele matched unrelated donor; all abo blood group combinations of the donor/recipient are acceptable since even major abo compatibilities can be dealt with by various techniques
boolean
C0037047 (UMLS CUI [1,1])
C0019728 (UMLS CUI [1,2])
C0205280 (UMLS CUI [1,3])
C0037047 (UMLS CUI [2,1])
C0019737 (UMLS CUI [2,2])
C0205280 (UMLS CUI [2,3])
C0037047 (UMLS CUI [3,1])
C0019751 (UMLS CUI [3,2])
C0205280 (UMLS CUI [3,3])
C0037047 (UMLS CUI [4,1])
C0019764 (UMLS CUI [4,2])
C0205280 (UMLS CUI [4,3])
C0037047 (UMLS CUI [5,1])
C1305211 (UMLS CUI [5,2])
C0600109 (UMLS CUI [5,3])
C0037047 (UMLS CUI [6,1])
C0018956 (UMLS CUI [6,2])
C0871133 (UMLS CUI [6,3])
C3179133 (UMLS CUI [7,1])
C1548978 (UMLS CUI [7,2])
C0000778 (UMLS CUI [8,1])
C0205195 (UMLS CUI [8,2])
C0040288 (UMLS CUI [8,3])
C1709854 (UMLS CUI [8,4])
VP-16 | Busulfan | Cytoxan
Item
prior therapy with vp-16, busulfan, and cytoxan is allowed
boolean
C0733688 (UMLS CUI [1])
C0006463 (UMLS CUI [2])
C0699319 (UMLS CUI [3])
Changes Ischemic Electrocardiography | Cardiac Arrhythmia Electrocardiography | Cardiac ejection fraction Multiple gated acquisition scanning | Cardiac ejection fraction Echocardiography
Item
a cardiac exam with a electrocardiogram showing no ischemic changes or abnormal rhythm and an ejection fraction of >= 50% established by multi gated acquisition scan (muga) or echocardiogram
boolean
C0392747 (UMLS CUI [1,1])
C0475224 (UMLS CUI [1,2])
C1623258 (UMLS CUI [1,3])
C0003811 (UMLS CUI [2,1])
C1623258 (UMLS CUI [2,2])
C0232174 (UMLS CUI [3,1])
C0521317 (UMLS CUI [3,2])
C0232174 (UMLS CUI [4,1])
C0013516 (UMLS CUI [4,2])
Creatinine measurement, serum | Creatinine clearance measurement
Item
patients must have a serum creatinine of less than or equal to 1.2 or creatinine clearance >= 80 ml/min
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Serum total bilirubin measurement
Item
bilirubin of less than or equal to 1.5
boolean
C1278039 (UMLS CUI [1])
Aspartate aminotransferase measurement
Item
serum glutamic oxaloacetic transaminase (sgot) less than 5 times the upper limit of normal
boolean
C0201899 (UMLS CUI [1])
Alanine aminotransferase measurement
Item
serum glutamic pyruvic transaminase (sgpt) less than 5 times the upper limit of normal
boolean
C0201836 (UMLS CUI [1])
Pulmonary function tests | Carbon Monoxide Diffusing Capability Test | PULMONARY FUNCTION TEST FEV1
Item
pulmonary functioning tests including diffusing capacity of carbon monoxide (dlco) will be performed; forced expiratory volume in one second (fev1) and dlco should be greater than 50% of the predicted normal value
boolean
C0024119 (UMLS CUI [1])
C1516251 (UMLS CUI [2])
C0748133 (UMLS CUI [3])
Remission Induction Therapy
Item
the time from the end last induction or reinduction attempt should be >= 14 days
boolean
C1514832 (UMLS CUI [1])
Informed Consent
Item
signed informed consent form approved by the institutional review board (irb) is required
boolean
C0021430 (UMLS CUI [1])
Sibling Donors Histocompatibility Recipient
Item
donor: any sibling donors who are histocompatible with the prospective recipient will be considered a suitable donor
boolean
C0037047 (UMLS CUI [1,1])
C0040288 (UMLS CUI [1,2])
C0019627 (UMLS CUI [1,3])
C1709854 (UMLS CUI [1,4])
Donors Excluded Due to Mental condition | Donors Excluded Due to Medical condition
Item
donor: donors will be excluded if for psychological or medical reasons they are unable to tolerate the procedure
boolean
C0040288 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C3840291 (UMLS CUI [1,4])
C0040288 (UMLS CUI [2,1])
C2828389 (UMLS CUI [2,2])
C0678226 (UMLS CUI [2,3])
C3843040 (UMLS CUI [2,4])
Donors Peripheral blood stem cells Donation Ability | Donors Donation of bone marrow Ability
Item
donor: donor should be able to donate peripheral blood stem cells or bone marrow
boolean
C0040288 (UMLS CUI [1,1])
C1518999 (UMLS CUI [1,2])
C0680854 (UMLS CUI [1,3])
C0085732 (UMLS CUI [1,4])
C0040288 (UMLS CUI [2,1])
C1305211 (UMLS CUI [2,2])
C0085732 (UMLS CUI [2,3])
Prior radiation therapy Excludes Whole-Body Irradiation
Item
prior radiation therapy that would exclude the use of total-body irradiation
boolean
C0279134 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0043162 (UMLS CUI [1,3])
Bone Marrow Transplantation | Recurrent disease
Item
patients who have undergone bone marrow transplantation previously and who have relapsed
boolean
C0005961 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
Mental condition Allogeneic bone marrow transplantation Unacceptable | Medical condition Allogeneic bone marrow transplantation Unacceptable
Item
patients with psychological or medical condition that patients physician deems unacceptable to proceed to allogeneic bone marrow transplant
boolean
C3840291 (UMLS CUI [1,1])
C0149615 (UMLS CUI [1,2])
C1883420 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0149615 (UMLS CUI [2,2])
C1883420 (UMLS CUI [2,3])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
Changes Ischemic Electrocardiography | Cardiac Arrhythmia Electrocardiography | Wall motion Abnormal Echocardiography | Wall motion Abnormal Multiple gated acquisition scanning | Cardiac ejection fraction Echocardiography | Cardiac ejection fraction Multiple gated acquisition scanning
Item
electrocardiogram (ekg) showing ischemic changes or abnormal rhythm and/or an echocardiogram or muga scan showing abnormal wall motion or ejection fraction < 50%
boolean
C0392747 (UMLS CUI [1,1])
C0475224 (UMLS CUI [1,2])
C1623258 (UMLS CUI [1,3])
C0003811 (UMLS CUI [2,1])
C1623258 (UMLS CUI [2,2])
C1980023 (UMLS CUI [3,1])
C0205161 (UMLS CUI [3,2])
C0013516 (UMLS CUI [3,3])
C1980023 (UMLS CUI [4,1])
C0205161 (UMLS CUI [4,2])
C0521317 (UMLS CUI [4,3])
C0232174 (UMLS CUI [5,1])
C0013516 (UMLS CUI [5,2])
C0232174 (UMLS CUI [6,1])
C0521317 (UMLS CUI [6,2])