ID.1
Item
1. cytologically or histologically confirmed stages ii or iii non-squamous nsclc
boolean
C0007131 (UMLS CUI [1,1])
C2585890 (UMLS CUI [1,2])
ID.2
Item
2. no evidence of tumour invading major blood vessels and no active hemoptysis (bright red blood of at least ½ teaspoon) in the 28 days prior to randomization.
boolean
C0019079 (UMLS CUI [1,1])
C1272790 (UMLS CUI [1,2])
ID.3
Item
3. no prior systemic therapy for nsclc. prior surgery and/or extra-thoracic irradiation is permitted.
boolean
C1515119 (UMLS CUI [1])
ID.4
Item
4. presence of at least one measurable target lesion
boolean
C2986546 (UMLS CUI [1])
ID.5
Item
5. age 18 or greater.
boolean
C0001779 (UMLS CUI [1])
ID.6
Item
6. who performance status of 0 or 1.
boolean
C1298650 (UMLS CUI [1])
ID.7
Item
7. acceptable pulmonary function as defined by a fev1 of ≥30% and a dlco of ≥40% of predicted
boolean
C0231921 (UMLS CUI [1])
ID.8
Item
8. life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1])
ID.9
Item
9. adequate hematological, renal and hepatic functions
boolean
C0232741 (UMLS CUI [1,1])
C0232804 (UMLS CUI [1,2])
ID.10
Item
absolute neutrophil count >2x109/l.
boolean
C0948762 (UMLS CUI [1])
ID.11
Item
platelet count > 100x109/l.
boolean
C0032181 (UMLS CUI [1])
ID.12
Item
total bilirubin < 1.5 x unl
boolean
C0005437 (UMLS CUI [1])
ID.13
Item
asat/alat < 2 x unl
boolean
C0004002 (UMLS CUI [1,1])
C0001899 (UMLS CUI [1,2])
ID.14
Item
alkaline phosphatase < 5 x unl
boolean
C0002059 (UMLS CUI [1])
ID.15
Item
creatinine < 130 μmol/l
boolean
C0010294 (UMLS CUI [1])
ID.16
Item
creatinine clearance > 60 ml/min; measured or calculated
boolean
C0373595 (UMLS CUI [1])
ID.17
Item
10. urine dipstick for proteinuria < 1+. if urine dipstick is ≥ 1, 24 hour urine must demonstrate < 500 mg of protein in 24 hours.
boolean
C0033687 (UMLS CUI [1])
ID.18
Item
11. no pre-existing sensory neurotoxicity grade 2 (ctc)
boolean
C0235032 (UMLS CUI [1])
ID.19
Item
12. no active (uncontrolled) infection requiring antibiotics
boolean
C3714514 (UMLS CUI [1])
ID.20
Item
1. mixed tumor types with small cell lung cancer or squamous cell carcinoma
boolean
C1368354 (UMLS CUI [1])
ID.21
Item
2. other serious diseases, such as heart failure, angina pectoris, myocardial infarction within the last 6 months, uncontrolled hypertension
boolean
C0012634 (UMLS CUI [1])
ID.22
Item
3. serious non-healing wound or ulcer.
boolean
C0750433 (UMLS CUI [1,1])
C0041582 (UMLS CUI [1,2])
ID.23
Item
4. asat and alat > 1,5 x unl
boolean
C0004002 (UMLS CUI [1,1])
C0001899 (UMLS CUI [1,2])
ID.24
Item
5. alkaline phosphatase 5 x unl
boolean
C0002059 (UMLS CUI [1])
ID.25
Item
6. evidence of bleeding diathesis or coagulopathy.
boolean
C0005779 (UMLS CUI [1])
ID.26
Item
7. any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be assessed with the patient before registration in the trial.
boolean
C1321605 (UMLS CUI [1])
ID.27
Item
8. participation in other trial with investigational drug or treatment modality.
boolean
C0013230 (UMLS CUI [1])