ID.1
Item
histologically or cytologically confirmed diagnosis of advanced non small cell lung cancer, not amenable to surgical or curative radiation therapy (stage iiib or iv);
boolean
C0007131 (UMLS CUI [1,1])
C1827320 (UMLS CUI [1,2])
C1828386 (UMLS CUI [1,3])
ID.2
Item
no prior or concomitant chemotherapy (adjuvant/neoadjuvant chemotherapy permitted if concluded at least one year prior to enrollment);
boolean
C0087111 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
ID.3
Item
ecog performance status 2;
boolean
C1520224 (UMLS CUI [1])
ID.4
Item
age: > or = 18 and < 70 years;
boolean
C0001779 (UMLS CUI [1])
ID.5
Item
life expectancy at least 4 weeks;
boolean
ID.6
Item
normal bone marrow, hepatic and renal function defined as: neutrophils > or = 2000/mm3, plt > or = 100,000/mm3, hb > or = 10.0 g/dl, bilirubin > or = 1.5 times the upper normal limit (unl), ast and alt < or = 3 times the unl (5 times in the presence of liver metastases), creatinine within normal limits;
boolean
C0005953 (UMLS CUI [1,1])
C0232804 (UMLS CUI [1,2])
C0232741 (UMLS CUI [1,3])
ID.7
Item
signed informed consent.
boolean
C0021430 (UMLS CUI [1])
ID.8
Item
active systemic infections;
boolean
C3714514 (UMLS CUI [1])
ID.9
Item
severe concomitant illness (congestive heart failure, angina pectoris, myocardial infarction within previous 6 months, cardiac arrhythmias under treatment, severe arterial hypertension, severe or uncontrolled diabetes mellitus);
boolean
C0012634 (UMLS CUI [1])
ID.10
Item
inadequate hepatic or renal function;
boolean
C0086565 (UMLS CUI [1,1])
C0022658 (UMLS CUI [1,2])
ID.11
Item
radiation therapy ongoing or concluded within two weeks prior to enrollment;
boolean
C1522449 (UMLS CUI [1])
ID.12
Item
symptomatic cerebral metastases;
boolean
C0555278 (UMLS CUI [1])
ID.13
Item
previous chemotherapy for advanced disease;
boolean
C0278940 (UMLS CUI [1])
ID.14
Item
any condition that would, in the investigator's opinion, limit the patients ability to provide informed consent or to comply with study procedures;
boolean
C0004936 (UMLS CUI [1])
ID.15
Item
pregnant or nursing females;
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
ID.16
Item
any malignancy within the past 5 years (except for adequately treated carcinoma in situ of the cervix or non melanoma skin cancer)
boolean
C0006826 (UMLS CUI [1])