Age
Item
between ages 18 and 59;
boolean
C0001779 (UMLS CUI [1])
Schizophrenia | Schizoaffective Disorder | Nicotine Dependence
Item
scid-i for dsm-iv diagnosis of schizophrenia or schizoaffective disorder, and nicotine dependence
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
C0028043 (UMLS CUI [3])
Tobacco use Number of cigarettes per day | breath test expired carbon monoxide
Item
smoking at least 15 cigarettes per day, and have expired breath co level >10 ppm,
boolean
C0543414 (UMLS CUI [1,1])
C3694146 (UMLS CUI [1,2])
C2207180 (UMLS CUI [2])
Psychiatric symptom | Remission Stable | Pharmaceutical Preparations Psychiatric Dose Stable
Item
be in stable remission from active psychiatric symptomatology, (as judged by trained clinical staff in the prism research program) and be on a stable dose of psychiatric medication(s) for the past 3 months
boolean
C0233401 (UMLS CUI [1])
C0544452 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C0013227 (UMLS CUI [3,1])
C0205487 (UMLS CUI [3,2])
C0178602 (UMLS CUI [3,3])
C0205360 (UMLS CUI [3,4])
Substance Use Disorders Absent | Substance Dependence Absent
Item
no current abuse or dependence of alcohol or other substances of abuse within the past 3 months,
boolean
C0038586 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0038580 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Intelligence quotient
Item
full scale iq > 80,
boolean
C0456149 (UMLS CUI [1])
Cognition Disorders | Visuospatial memory deficit | Wisconsin card sorting test
Item
presence of definable cognitive deficits of interest including vswm, cpt, and wcst (e.g. at least one standard deviation below average).
boolean
C0009241 (UMLS CUI [1])
C4228414 (UMLS CUI [2])
C0451592 (UMLS CUI [3])
Informed Consent
Item
able to give informed consent for participation.
boolean
C0021430 (UMLS CUI [1])
Axis I diagnosis Major
Item
meet dsm-iv criteria for other major axis i disorders besides those specified for each diagnostic group.
boolean
C0270287 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
Substance Use Disorders | Substance Dependence | Methadone maintenance
Item
current abuse or dependence of alcohol or substances within the last 3 months, and subjects who are methadone maintained will be excluded.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
C0588202 (UMLS CUI [3])
Intelligence quotient
Item
full scale iq < 80.
boolean
C0456149 (UMLS CUI [1])
Informed Consent Unable
Item
unable to give informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Pregnancy | Pregnancy, Planned
Item
patients who are pregnant or planning on becoming pregnant will not be included in this study.
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
Paroxetine | Fluoxetine | Quinidine
Item
patients on paroxetine, fluoxetine, and quinidine will be excluded from this study.
boolean
C0070122 (UMLS CUI [1])
C0016365 (UMLS CUI [2])
C0034414 (UMLS CUI [3])
Medical contraindication atomoxetine | Hypersensitivity atomoxetine | Monoamine Oxidase Inhibitors | Angle Closure Glaucoma | Cytochrome P-450 CYP2D6 inhibitors | Paroxetine | Fluoxetine | Quinidine | Liver diseases | Risk Toxicity | Liver Failure | Hypertensive disease | Tachycardia | Cardiovascular Diseases | Cerebrovascular Disorders | Hypotension | Risk Hypotension | Urinary Retention | Bladder dysfunction
Item
are deemed medically unsafe to take atomoxetine, as judged by the study physician. contraindications to the use of atomoxetine include hypersensitivity to atomoxetine, concurrent use of monoamine oxidase inhibitors (atomoxetine should be avoided during therapy with or within 2 weeks of discontinuing an mao inhibitor), and patients with narrow angle glaucoma. precautions would include concomitant administration with cyp 2d6 inhibitors (eg, paroxetine, fluoxetine, quinidine) (which would necessitate a dose adjustment with atomoxetine), liver disease (enhanced risk of toxicity; empiric dose reduction is suggested based on clinical response; the drug should be avoided in acute hepatic failure), patients with hypertension, tachycardia, or other cardiovascular or cerebrovascular disease, patients with or at risk of hypotension , patients with urinary retention or bladder dysfunction.
boolean
C1301624 (UMLS CUI [1,1])
C0076823 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0076823 (UMLS CUI [2,2])
C0026457 (UMLS CUI [3])
C0017605 (UMLS CUI [4])
C0057223 (UMLS CUI [5,1])
C0243077 (UMLS CUI [5,2])
C0070122 (UMLS CUI [6])
C0016365 (UMLS CUI [7])
C0034414 (UMLS CUI [8])
C0023895 (UMLS CUI [9])
C0035647 (UMLS CUI [10,1])
C0600688 (UMLS CUI [10,2])
C0085605 (UMLS CUI [11])
C0020538 (UMLS CUI [12])
C0039231 (UMLS CUI [13])
C0007222 (UMLS CUI [14])
C0007820 (UMLS CUI [15])
C0020649 (UMLS CUI [16])
C0035647 (UMLS CUI [17,1])
C0020649 (UMLS CUI [17,2])
C0080274 (UMLS CUI [18])
C0232841 (UMLS CUI [19])