Age
Item
males or females, 18 years of age or older.
boolean
C0001779 (UMLS CUI [1])
Anemia, Sickle Cell | electrophoretic analysis of hemoglobin SS | electrophoretic analysis of hemoglobin SC | Hemoglobin S genotype Electrophoresis | Thalassemia
Item
diagnosis of sickle cell disease (electrophoretic documentation of ss, sc, or s thalassemia genotype is required) or thalassemia.
boolean
C0002895 (UMLS CUI [1])
C2208594 (UMLS CUI [2])
C2208592 (UMLS CUI [3])
C1261533 (UMLS CUI [4,1])
C0013855 (UMLS CUI [4,2])
C0039730 (UMLS CUI [5])
Gender Contraceptive methods | Gender Infertility
Item
for female subjects, on a reliable method of birth control or not physically able to bear children.
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0021359 (UMLS CUI [2,2])
WHO Pulmonary arterial hypertension Class Functional
Item
for stage ii:
boolean
C0043237 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
C0205245 (UMLS CUI [1,4])
Pulmonary hypertension, mild | Pulmonary hypertension, severe | Pulmonary artery mean pressure At rest | Pulmonary artery mean pressure During Exercise | Pulmonary Artery Catheterization
Item
mild to severe pulmonary hypertension with mean pulmonary artery pressure greater than 25 mm hg at rest or greater than 30 mm hg during exercise, measured by pulmonary artery catheterization.
boolean
C3807623 (UMLS CUI [1])
C2750273 (UMLS CUI [2])
C0428645 (UMLS CUI [3,1])
C0443144 (UMLS CUI [3,2])
C0428645 (UMLS CUI [4,1])
C0347984 (UMLS CUI [4,2])
C0015259 (UMLS CUI [4,3])
C0190658 (UMLS CUI [5])
Pulmonary Wedge Pressure | Left ventricular end-diastolic pressure measurement | Gradient Pulmonary artery diastolic pressure Pulmonary Wedge Pressure | Echocardiography criteria Left Ventricular Dysfunction Exclusion
Item
pulmonary artery wedge pressure or left ventricular end-diastolic pressure less than or equal to 18 mm hg or gradient between pulmonary artery diastolic pressure and wedge pressure greater than 8 mm hg or echocardiographic criteria to exclude left ventricular dysfunction.
boolean
C0034094 (UMLS CUI [1])
C1171395 (UMLS CUI [2])
C0812409 (UMLS CUI [3,1])
C0428644 (UMLS CUI [3,2])
C0034094 (UMLS CUI [3,3])
C0013516 (UMLS CUI [4,1])
C0243161 (UMLS CUI [4,2])
C0242698 (UMLS CUI [4,3])
C2828389 (UMLS CUI [4,4])
Gender Contraceptive methods | Gender Infertility
Item
for female subjects, on a reliable method of birth control or not physically able to bear children.
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0021359 (UMLS CUI [2,2])
WHO Pulmonary arterial hypertension Class Functional
Item
for stage iii:
boolean
C0043237 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
C0205245 (UMLS CUI [1,4])
Pulmonary hypertension, mild | Pulmonary hypertension, severe | Pulmonary artery mean pressure At rest | Pulmonary artery mean pressure During Exercise | Pulmonary Artery Catheterization | sildenafil chronic | Combination Drug Therapy | Endothelin receptor antagonist | Prostaglandins I
Item
mild to severe pulmonary hypertension with mean pulmonary artery pressure greater than 25 mm hg at rest or greater than 30 mm hg during exercise, measured by pulmonary artery catheterization in patients on chronic sildenafil therapy for at least three months. patients receiving combination drug therapy with other drugs (e.g., endothelin antagonists, prostacyclins) are allowed to participate in stage iii as long as sildenafil is one of the components of the combination regimen.
boolean
C3807623 (UMLS CUI [1])
C2750273 (UMLS CUI [2])
C0428645 (UMLS CUI [3,1])
C0443144 (UMLS CUI [3,2])
C0428645 (UMLS CUI [4,1])
C0347984 (UMLS CUI [4,2])
C0015259 (UMLS CUI [4,3])
C0190658 (UMLS CUI [5])
C0529793 (UMLS CUI [6,1])
C0205191 (UMLS CUI [6,2])
C0013218 (UMLS CUI [7])
C1134681 (UMLS CUI [8])
C0205911 (UMLS CUI [9])
Pulmonary Wedge Pressure | Left ventricular end-diastolic pressure measurement | Gradient Pulmonary artery diastolic pressure Pulmonary Wedge Pressure | Echocardiography criteria Left Ventricular Dysfunction Exclusion
Item
pulmonary artery wedge pressure or left ventricular end-diastolic pressure less than or equal to 18 mm hg or gradient between pulmonary artery diastolic pressure and wedge pressure greater than 8 mm hg or echocardiographic criteria to exclude left ventricular dysfunction.
boolean
C0034094 (UMLS CUI [1])
C1171395 (UMLS CUI [2])
C0812409 (UMLS CUI [3,1])
C0428644 (UMLS CUI [3,2])
C0034094 (UMLS CUI [3,3])
C0013516 (UMLS CUI [4,1])
C0243161 (UMLS CUI [4,2])
C0242698 (UMLS CUI [4,3])
C2828389 (UMLS CUI [4,4])
Sildenafil chronic Dose Stable
Item
must be on chronic sildenafil therapy on a stable dose for at least three months.
boolean
C0529793 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0178602 (UMLS CUI [1,3])
C0205360 (UMLS CUI [1,4])
Gender Contraceptive methods | Gender Infertility
Item
for female subjects, on a reliable method of birth control or not physically able to bear children.
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0021359 (UMLS CUI [2,2])
WHO Pulmonary arterial hypertension Class Functional
Item
for stage i
boolean
C0043237 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
C0205245 (UMLS CUI [1,4])
Pregnancy | Breast Feeding
Item
current pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Condition Affecting research results | Condition Affecting patient safety
Item
any condition that in the opinion of the study investigators would adversely affect the outcome of the study or the safety of the volunteer.
boolean
C0348080 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0683954 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
WHO Pulmonary arterial hypertension Class Functional
Item
for stage ii and iii:
boolean
C0043237 (UMLS CUI [1,1])
C2973725 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
C0205245 (UMLS CUI [1,4])
Pregnancy | Breast Feeding
Item
current pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Medical condition
Item
any of the following medical conditions
boolean
C3843040 (UMLS CUI [1])
Cerebrovascular accident
Item
1. stroke within the last six weeks.
boolean
C0038454 (UMLS CUI [1])
Priapism Sustained Requirement Therapeutic procedure | Priapism Sustained Requirement Operative Surgical Procedures | Erectile dysfunction | Exchange Transfusion, Whole Blood
Item
2. history of sustained priapism requiring medical or surgical treatment, unless currently impotent or on exchange transfusion therapy, within two years.
boolean
C0033117 (UMLS CUI [1,1])
C0443318 (UMLS CUI [1,2])
C1514873 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C0033117 (UMLS CUI [2,1])
C0443318 (UMLS CUI [2,2])
C1514873 (UMLS CUI [2,3])
C0543467 (UMLS CUI [2,4])
C0242350 (UMLS CUI [3])
C0015236 (UMLS CUI [4])