schizophrenia
Item
diagnosis of schizophrenia, any subtype
boolean
C0036341 (UMLS CUI [1])
antipsychotic medication stable dose
Item
treated with an antipsychotic medication for at least 6 months at a stable dose for at least 6 weeks before study entry
boolean
C0040615 (UMLS CUI [1,1])
C0678766 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
panss
Item
panss total score of at least 60, with a score of at least 3 (moderate) on one negative symptom item or on one positive symptom item
boolean
C0451383 (UMLS CUI [1])
simpson angus scale for extrapyramidal syndrome
Item
simpson angus scale (sas) for extrapyramidal syndrome (eps) total score of 12 or less
boolean
C0450973 (UMLS CUI [1,1])
C0015371 (UMLS CUI [1,2])
calgary depression scale
Item
a score of 2 (mild) or less on all items of the calgary depression scale (cds)
boolean
C0679604 (UMLS CUI [1])
english
Item
speaks english adequately enough to complete cognitive testing
boolean
C0376245 (UMLS CUI [1])
serum b12 concentration
Item
serum b12 concentration less than 300 ug/l
boolean
C0427408 (UMLS CUI [1])
megaloblastic anemia
Item
complete blood count results consistent with megaloblastic anemia
boolean
C0002888 (UMLS CUI [1])
creatinine
Item
serum creatinine concentration greater than 1.4
boolean
C0201976 (UMLS CUI [1])
folate or b12 supplementation
Item
current use of folate or b12 supplementation
boolean
C0556110 (UMLS CUI [1])
C0042845 (UMLS CUI [2,1])
C0242297 (UMLS CUI [2,2])
phenobarbital, phenytoin, carbamazepine, valproic acid, fosphenytoin, primidone, pyrimethamine
Item
current use of any of the following medications: phenobarbital, phenytoin, carbamazepine, valproic acid, fosphenytoin, primidone, or pyrimethamine
boolean
C0031412 (UMLS CUI [1])
C0031507 (UMLS CUI [2])
C0006949 (UMLS CUI [3])
C0042291 (UMLS CUI [4])
C0244656 (UMLS CUI [5])
C0033148 (UMLS CUI [6])
C0034283 (UMLS CUI [7])
substance use disorder, tobacco use
Item
alcohol or other substance abuse within 3 months before study entry (nicotine allowed)
boolean
C0038586 (UMLS CUI [1])
C0543414 (UMLS CUI [2])
positive urine toxic screen
Item
positive baseline urine toxic screen
boolean
C2702984 (UMLS CUI [1,1])
C1446409 (UMLS CUI [1,2])
unstable medical illness
Item
unstable medical illness
boolean
C0009488 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
unstable psychiatric illness
Item
unstable psychiatric illness
boolean
C0004936 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
epilepsy
Item
seizure disorder
boolean
C0014544 (UMLS CUI [1])
pregnancy, breast feeding
Item
pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])