rheumatoid arthritis, swollen joints, tender joints
Item
met acr criteria for diagnosis of active rheumatoid arthritis (ra) and have had at both the screening visit and week 0 visit at least four swollen joints (out of 66 assessed) and at least six tender joints(out of 68 assessed)
boolean
C0003873 (UMLS CUI [1])
C0451521 (UMLS CUI [2])
C0451530 (UMLS CUI [3])
failed prior treatment with one or more disease-modifying antirheumatic drugs
Item
subjects must have failed prior treatment with one or more disease-modifying antirheumatic drugs (dmards)
boolean
C0162643 (UMLS CUI [1,1])
C0242708 (UMLS CUI [1,2])
dmard discontinuation
Item
dmards (other than methotrexate [mtx]) must have been discontinued for >= 28 days or at least 5 half-lives, whichever is greater, before the week 0 visit
boolean
C0242708 (UMLS CUI [1,1])
C4288399 (UMLS CUI [1,2])
traditional chinese medicine
Item
traditional chinese medicines must have been discontinued for >= 28 days before the week 0 visit
boolean
C0025124 (UMLS CUI [1,1])
C0457454 (UMLS CUI [1,2])
methotrexat duration, stable dose
Item
subjects must have received at least three months of treatment with mtx (minimum 7.5 mg/week) and remained on a stable dose of mtx for >= 28 days prior to the screening visit
boolean
C0025677 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0025677 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C0178602 (UMLS CUI [2,3])
steroid therapy, stable status
Item
glucocorticoids equivalent to <= 10 mg of prednisone and prednisone equivalent must have remained unchanged for at least 28 days prior to the week 0 visit
boolean
C0149783 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
informed consent, protocol compliance
Item
must have been able and willing to give written informed consent and to comply with the requirements of this study protocol
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
inflammatory joint disease, mixed connective tissue disease, seronegative spondyloarthropathy, psoriatic arthritis, reiter's syndrome, systemic lupus erythematosus, fibromyalgia or any arthritide with onset prior to age 16 years
Item
a history of, or current, acute inflammatory joint disease of different origin (e.g., mixed connective tissue disease, seronegative spondyloarthropathy, psoriatic arthritis, reiter's syndrome, systemic lupus erythematosus, fibromyalgia or any arthritide with onset prior to age 16 years
boolean
C0683381 (UMLS CUI [1,1])
C0026272 (UMLS CUI [1,2])
C0949691 (UMLS CUI [1,3])
C0003872 (UMLS CUI [1,4])
C0035012 (UMLS CUI [1,5])
C0024141 (UMLS CUI [1,6])
C0016053 (UMLS CUI [1,7])
C1444845 (UMLS CUI [1,8])
wheelchair bound or bedridden
Item
wheelchair-bound or bedridden
boolean
C0558195 (UMLS CUI [1])
C0741453 (UMLS CUI [2])
joint surgery
Item
joint surgery involving joints to be assessed within this study, within two months prior to the screening visit
boolean
C0185132 (UMLS CUI [1])
intra-articular, intramuscular or intravenous administration of corticosteroids
Item
intra-articular, intramuscular or intravenous administration of corticosteroids within 28 days prior to the screening visit
boolean
C2064783 (UMLS CUI [1])
C0585373 (UMLS CUI [2])
C0563322 (UMLS CUI [3])
prior therapy with any tnf antagonist
Item
prior treatment with any tnf antagonist, including adalimumab
boolean
C1514463 (UMLS CUI [1,1])
C3653350 (UMLS CUI [1,2])
unsuitable for other reasons
Item
subject considered by the investigator, for any reason, to be an unsuitable candidate
boolean
C3844399 (UMLS CUI [1])
pregnancy, breast feeding, childbearing potential
Item
female subject who is pregnant or breast-feeding or considering becoming pregnant
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3])