informed consent
Item
they or their legal representative must have signed an informed consent document for clinical research
boolean
C0021430 (UMLS CUI [1])
nonsquamous cell nsclc, tumor stage, incurable
Item
have laboratory confirmed diagnosis of advanced, nonsquamous cell nsclc (stage iiib or iv disease) which is not curable
boolean
C2585890 (UMLS CUI [1,1])
C1300072 (UMLS CUI [1,2])
C0175969 (UMLS CUI [1,3])
prior therapy, chemotherapy, immunotherapy, targeted therapy, or biological therapy, prior radiation therapy, advanced nsclc
Item
have not received any prior systemic chemotherapy, immunotherapy, targeted therapy, or biological therapy for advanced nsclc, prior radiation therapy is allowed to less than 25% of the bone marrow
boolean
C1514463 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C0021083 (UMLS CUI [1,3])
C2985566 (UMLS CUI [1,4])
C0005527 (UMLS CUI [1,5])
C0205179 (UMLS CUI [1,6])
C0007131 (UMLS CUI [1,7])
C0279134 (UMLS CUI [2,1])
C0205179 (UMLS CUI [2,2])
C0007131 (UMLS CUI [2,3])
measurable disease
Item
have measurable disease
boolean
C1513041 (UMLS CUI [1])
organ function, life expectancy
Item
have adequate organ function and estimated life expectancy of 12 weeks
boolean
C0678852 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
cns disease, major surgery; minor surgery; serious systemic disorder; serious cardiac condition; nonhealing wound, ulcer, or bone fracture
Item
have known cns disease; major surgery within 28 days; minor surgery within 7 days; serious concommitant systemic disorder; serious cardiac condition; have a serious, nonhealing wound, ulcer, or bone fracture
boolean
C0007682 (UMLS CUI [1])
C0679637 (UMLS CUI [2])
C0038904 (UMLS CUI [3])
C0442893 (UMLS CUI [4])
C0018799 (UMLS CUI [5])
C0043250 (UMLS CUI [6,1])
C3845448 (UMLS CUI [6,2])
C0041582 (UMLS CUI [7,1])
C3845448 (UMLS CUI [7,2])
C0016658 (UMLS CUI [8,1])
C3845448 (UMLS CUI [8,2])
prior therapy, drugs, regulatory approval
Item
have received treatment within the last 30 days with any drug that has not received regulatory approval for any indication at the time of study entry
boolean
C1514463 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C3899556 (UMLS CUI [1,3])
prior therapy enzastaurin, pemetrexed, or bevacizumab
Item
have previously received treatment with enzastaurin, pemetrexed, or bevacizumab
boolean
C1514463 (UMLS CUI [1,1])
C1327830 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0210657 (UMLS CUI [2,2])
C1514463 (UMLS CUI [3,1])
C0796392 (UMLS CUI [3,2])
pregnancy, breast feeding
Item
are pregnant or breast-feeding
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
are unable to swallow tablets
Item
are unable to swallow tablets
boolean
C0566355 (UMLS CUI [1,1])
C0039225 (UMLS CUI [1,2])