Parkinson Disease
Item
1. uk parkinson's disease society (ukpds) brain bank criteria (step 1 and 2) for pd.
boolean
C0030567 (UMLS CUI [1])
Parkinson Disease Modified Hoehn and Yahr Staging
Item
2. pd stages 2-4 in the off state for modified hoehn and yahr scale.
boolean
C0030567 (UMLS CUI [1,1])
C3639878 (UMLS CUI [1,2])
Levodopa Dose Stable | Decarboxylase inhibitor Dose Stable
Item
3. on levodopa/dci for at least one year, stable dose in past 4 weeks.
boolean
C0023570 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0360140 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Levodopa Dose Quantity Daily | Decarboxylase inhibitor Dose Quantity Daily
Item
4. currently take at least three doses of levodopa/dci per day.
boolean
C0023570 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0332173 (UMLS CUI [1,4])
C0360140 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0332173 (UMLS CUI [2,4])
Dose Wearing off End Expected
Item
5. predictable end of dose wearing off.
boolean
C0178602 (UMLS CUI [1,1])
C1504539 (UMLS CUI [1,2])
C2746065 (UMLS CUI [1,3])
C1517001 (UMLS CUI [1,4])
Parkinson Disease Subject Diary Completion
Item
6. able to satisfactorily complete hauser version of a parkinson's diary.
boolean
C0030567 (UMLS CUI [1,1])
C3890583 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
Subject Diary Timing
Item
7. have an average of 120 minutes of off time on two 24 hour diaries.
boolean
C3890583 (UMLS CUI [1,1])
C0449243 (UMLS CUI [1,2])
Pharmaceutical Preparations Stable Parkinson Disease
Item
8. on a stable regimen of medications being administered within normal therapeutic limits for parkinson's disease for at least four weeks before randomization.
boolean
C0013227 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
Age
Item
9. be at least 30 years of age.
boolean
C0001779 (UMLS CUI [1])
Neurosurgical Procedures Parkinson Disease
Item
1. neurosurgical treatment for pd.
boolean
C0524850 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
Psychotic Disorders
Item
2. history of psychosis.
boolean
C0033975 (UMLS CUI [1])
Atypical Parkinson Disease | Secondary parkinsonism
Item
3. diagnosis of atypical parkinsonism or secondary parkinsonism variant.
boolean
C1868596 (UMLS CUI [1])
C0477357 (UMLS CUI [2])
Malignant Neoplasms
Item
4. diagnosis of cancer within 5 years.
boolean
C0006826 (UMLS CUI [1])
Illness Organ system
Item
5. diagnosis of clinically significant illness of any organ system.
boolean
C0221423 (UMLS CUI [1,1])
C0460002 (UMLS CUI [1,2])
Mini-mental state examination score
Item
6. mini-mental status examination score of 25 or less.
boolean
C2960235 (UMLS CUI [1])
Intake Pharmaceutical Preparations Excluded
Item
7. taking any excluded medications.
boolean
C1512806 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C2828389 (UMLS CUI [1,3])
Substance Use Disorders | Substance Dependence
Item
8. history of drug or alcohol abuse or dependence within the past two years.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Seizures | malignant neosplasm of the neurological system
Item
9. history of seizures or neurological malignant syndrome.
boolean
C0036572 (UMLS CUI [1])
C0848182 (UMLS CUI [2])
clinical depression
Item
10. clinical depression.
boolean
C2362914 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
11. pregnant or lactating females.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])