inclusion criteria
Item
all participants must meet the following criteria:
boolean
C1512693 (UMLS CUI [1])
age
Item
age 18 60
boolean
C0001779 (UMLS CUI [1])
tobacco use
Item
smoke 10 or more cigarettes/day for at least the past year
boolean
C0543414 (UMLS CUI [1])
additional criteria
Item
experimental groups 1 and 2, additional criteria:
boolean
C1516637 (UMLS CUI [1])
dsm-iv schizophrenia or schizoaffective disorder
Item
dsm-iv diagnosis of schizophrenia or schizoaffective disorder (assessments pertaining to these diagnoses will be done in other mprc screening protocols).
boolean
C0220952 (UMLS CUI [1,1])
C0036341 (UMLS CUI [1,2])
C0036337 (UMLS CUI [1,3])
additional criteria
Item
experimental group 2, additional criteria:
boolean
C1516637 (UMLS CUI [1])
substance use disorder, cocaine, heroin, methadone, buprenorphine
Item
dsm-iv diagnosis of abuse or dependence on cocaine and/or heroin or on methadone or buprenorphine maintenance.
boolean
C0038586 (UMLS CUI [1,1])
C0009170 (UMLS CUI [1,2])
C0011892 (UMLS CUI [1,3])
C0025605 (UMLS CUI [1,4])
C0006405 (UMLS CUI [1,5])
medical history
Item
comprehensive medical history:
boolean
C0262926 (UMLS CUI [1])
heart disease, blood pressure, neurological disorder, asthma, emphysema, chronic bronchitis, copd, pathology of nasal passages
Item
exclusions: heart disease, uncontrolled blood pressure (persistent systolic above 155 or diastolic above 95), neurological conditions (stroke, seizure, history of head injury), asthma, emphysema, chronic bronchitis, chronic obstructive pulmonary disease, pathology of nasal passages that precludes the effective administration of nicotine nasal spray.
boolean
C0018799 (UMLS CUI [1])
C0005823 (UMLS CUI [2])
C0027765 (UMLS CUI [3])
C0004096 (UMLS CUI [4])
C0034067 (UMLS CUI [5])
C0008677 (UMLS CUI [6])
C0024117 (UMLS CUI [7])
C0027424 (UMLS CUI [8])
drugs
Item
drug use survey
boolean
C0013227 (UMLS CUI [1])
study subject
Item
all subjects:
boolean
C0681850 (UMLS CUI [1])
tobacco dependence treatment
Item
exclude if treatment for tobacco dependence during the previous 6 months.
boolean
C0040332 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
substance use disorders
Item
healthy controls and schizophrenic patients without comorbid drug abuse or dependence: exclude if history alcohol or other substance dependence ever, or alcohol or other substance abuse in the past year. verify abstinence from controlled substances with urine screen (iscreen). participants in the above 2 groups who are positive for any illicit drug (with the exception of marijuana) will be excluded.
boolean
C0038586 (UMLS CUI [1])
structured clinical interview for dsm-iv
Item
structured clinical interview for dsm-iv
boolean
C0935589 (UMLS CUI [1,1])
C0220952 (UMLS CUI [1,2])
healthy controls, psychiatric disorders
Item
healthy controls: exclude if any current psychiatric disorder
boolean
C2986479 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
pregnancy
Item
urine pregnancy for females:
boolean
C0032961 (UMLS CUI [1])
pregnancy test
Item
exclude if positive.
boolean
C0032976 (UMLS CUI [1])