nsclc stage
Item
pathologically confirmed stage iiib or iv recurrent or progressive nsclc
boolean
C0007131 (UMLS CUI [1,1])
C0178759 (UMLS CUI [1,2])
disease progression while egfr tyrosine kinase inhibitor
Item
patients must have progressed while receiving treatment with a tyrosine kinase inhibitor targeting the egfr pathway
boolean
C0242656 (UMLS CUI [1,1])
C1443775 (UMLS CUI [1,2])
recist criteria
Item
measurable disease, as defined by recist criteria
boolean
C1709926 (UMLS CUI [1])
egfr mutational status
Item
patients must have a suitable frozen or paraffin-embedded tissue sample available for egfr mutational analysis. prior egfr mutational analyses are allowable
boolean
C3266973 (UMLS CUI [1])
asymptomatic brain metastasis, radiotherapy
Item
patients with asymptomatic brain metastasis are eligible; however, they must have completed radiotherapy/radiosurgery at least 3 weeks prior to enrollment and be clinically stable
boolean
C0220650 (UMLS CUI [1,1])
C0231221 (UMLS CUI [1,2])
C1522449 (UMLS CUI [1,3])
ecog
Item
ecog performance status 0-2
boolean
C1520224 (UMLS CUI [1])
age
Item
18 years of age or older
boolean
C0001779 (UMLS CUI [1])
pregnancy test
Item
negative pregnancy test within 7 days of treatment or be categorized as not of child-bearing potential
boolean
C0032976 (UMLS CUI [1])
bone marrow, renal, hepatic function
Item
bone marrow function, renal function, hepatic function as outlined in protocol
boolean
C0005953 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
pregnancy, breast feeding
Item
women who are pregnant of breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
concurrent malignancy
Item
active concurrent malignancy
boolean
C0006826 (UMLS CUI [1])
major surgery
Item
major thoracic or abdominal surgery within 30 days prior to the first infusion of cetuximab
boolean
C0679637 (UMLS CUI [1])
cardiac disease
Item
significant history of uncontrolled cardiac disease
boolean
C0018799 (UMLS CUI [1])
seizure disorder, neurological disease
Item
uncontrolled seizure disorder, or active neurological disease
boolean
C0014544 (UMLS CUI [1])
C0027765 (UMLS CUI [2])
monoclonal antibodies adverse event
Item
prior severe infusion reactions to a monoclonal antibody
boolean
C0003250 (UMLS CUI [1,1])
C0877248 (UMLS CUI [1,2])
chemotherapy
Item
prior chemotherapy regimen within 21 days prior to study entry
boolean
C0392920 (UMLS CUI [1])
egfr tyrosine kinase inhibitors
Item
any egfr tyrosine kinase inhibitor within 14 days of study entry
boolean
C1443775 (UMLS CUI [1])
radiotherapy
Item
radiation therapy within 14 days prior to the first infusion of cetuximab
boolean
C1522449 (UMLS CUI [1])
acute hepatitis, hiv
Item
acute hepatitis or known hiv
boolean
C0267797 (UMLS CUI [1])
C0019682 (UMLS CUI [2])
infection
Item
active or uncontrolled infection
boolean
C0009450 (UMLS CUI [1])
concurrent chemotherapy, investigational agents
Item
any concurrent chemotherapy or any other investigational agent(s)
boolean
C0392920 (UMLS CUI [1,1])
C0009429 (UMLS CUI [1,2])
C0013230 (UMLS CUI [2])