gender
Item
males and females
boolean
C0079399 (UMLS CUI [1])
race
Item
any race
boolean
C0034510 (UMLS CUI [1])
age
Item
between the ages of 18 and 70 years
boolean
C0001779 (UMLS CUI [1])
multiple sclerosis macdonald criteria
Item
diagnosed with a clinically isolated syndrome or the diagnosis of multiple sclerosis using the widely established macdonald criteria.
boolean
C0026769 (UMLS CUI [1,1])
C2921627 (UMLS CUI [1,2])
C0243161 (UMLS CUI [1,3])
multiple sclerosis
Item
a 'clinically isolated syndrome' refers to an isolated attack of optic neuritis, transverse myelitis, or brain demyelination. relapsing-remitting ms is characterized by acute relapses that are followed by some degree of recovery without worsening of disability between relapses. chronic progressive ms is defined as sustained progression of physical disability, occurring separately from relapses, in patients with ms.
boolean
C0026769 (UMLS CUI [1])
control subjects
Item
control subjects will be male or female, between the ages 18 to 70 years, of any race, with no symptoms of ms.
boolean
C0009932 (UMLS CUI [1])
children
Item
children are excluded from the study because ms is generally a disease of young adult onset and is rare in children.
boolean
C0008059 (UMLS CUI [1])
infection, cancer, systemic disease, anticoagulation, bleeding disorder, drug abuse, medication change
Item
evidence of infection or communicable disease, cancer or other known systemic disease, anti-coagulation, known bleeding disorder, illicit drug abuse, or change in medications in the last 30 days (including treatment with steroids).
boolean
C0009450 (UMLS CUI [1])
C0006826 (UMLS CUI [2])
C0442893 (UMLS CUI [3])
C0003281 (UMLS CUI [4])
C0005779 (UMLS CUI [5])
C0013146 (UMLS CUI [6])
C0580105 (UMLS CUI [7])
immune modulating medications
Item
patients receiving any other immune modulating medications (steroids, cyclophosphamide, mitoxantrone, methotrexate, mycophenolate mofetil, azathioprine, ivig or rituximab) in the prior thirty days will be excluded from the study
boolean
C0013227 (UMLS CUI [1,1])
C0678889 (UMLS CUI [1,2])