Meningeal Carcinomatosis | Meningeal Leukemia | Cerebrospinal Fluid Cytological Techniques Negative | MRI brain | CT brain | Signs and Symptoms Consistent with Meningeal Carcinomatosis
Item
cytologically confirmed, or radiographic evidence for lymphomatous or leukemic meningitis. if the csf cytology is negative, patients must have mri/ct brain and clinical findings consistent with neoplastic meningitis.
boolean
C0220654 (UMLS CUI [1])
C0948840 (UMLS CUI [2])
C0007806 (UMLS CUI [3,1])
C0010818 (UMLS CUI [3,2])
C1513916 (UMLS CUI [3,3])
C0412675 (UMLS CUI [4])
C0412585 (UMLS CUI [5])
C0037088 (UMLS CUI [6,1])
C0332290 (UMLS CUI [6,2])
C0220654 (UMLS CUI [6,3])
Karnofsky Performance Status
Item
karnofsky performance score of 60 or above.
boolean
C0206065 (UMLS CUI [1])
Age
Item
age ≥ 18 years.
boolean
C0001779 (UMLS CUI [1])
Hematologic function | Renal function | Liver function | Laboratory Results
Item
patients must have adequate hematologic, renal and liver function. laboratory
boolean
C0221130 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
C1254595 (UMLS CUI [4])
Absolute neutrophil count | White Blood Cell Count procedure
Item
absolute neutrophil count (anc) ≥ 1,500/mm3 or white blood cell count > 3,000/mm3
boolean
C0948762 (UMLS CUI [1])
C0023508 (UMLS CUI [2])
Platelet Count measurement
Item
platelet count ≥ 100, 000/mm3
boolean
C0032181 (UMLS CUI [1])
Blood urea nitrogen measurement | Creatinine measurement, serum
Item
bun and serum creatinine must be ≤ 1.5 times upper limit of laboratory normal
boolean
C0005845 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Serum total bilirubin measurement | Bilirubin, direct measurement
Item
total and direct serum bilirubin must be ≤ 1.5 times upper limit of laboratory normal
boolean
C1278039 (UMLS CUI [1])
C0201916 (UMLS CUI [2])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
sgot and sgpt ≤ 3.0 times upper limit of laboratory normal
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Serum alkaline phosphatase - liver
Item
alkaline phosphatase derived from liver ≤ 2.0 times upper limit of laboratory normal
boolean
C0857886 (UMLS CUI [1])
Communicable Disease Uncontrolled | Antiretroviral therapy HIV Infection
Item
no uncontrolled infection other than human immunodeficiency virus that is being treated with anti-retroviral therapy
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C1963724 (UMLS CUI [2,1])
C0019693 (UMLS CUI [2,2])
Therapeutic radiology procedure Central Nervous System | Methotrexate Intrathecal | Central Nervous System Prophylaxis | Cytarabine Intrathecal | Cytarabine Intravenous | Methotrexate
Item
patients who have had prior cns radiation, prior intrathecal methotrexate, and prior cns prophylaxis with intrathecal or intravenous cytarabine or methotrexate are eligible
boolean
C1522449 (UMLS CUI [1,1])
C3714787 (UMLS CUI [1,2])
C0025677 (UMLS CUI [2,1])
C0677897 (UMLS CUI [2,2])
C1516386 (UMLS CUI [3])
C0010711 (UMLS CUI [4,1])
C0677897 (UMLS CUI [4,2])
C0010711 (UMLS CUI [5,1])
C1522726 (UMLS CUI [5,2])
C0025677 (UMLS CUI [6])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Chemotherapy Investigational | Immunotherapy Investigational | Biological treatment Investigational
Item
experimental/investigational chemotherapy, immunotherapy, or biologic therapy within four weeks prior to study
boolean
C0392920 (UMLS CUI [1,1])
C1517586 (UMLS CUI [1,2])
C0021083 (UMLS CUI [2,1])
C1517586 (UMLS CUI [2,2])
C1531518 (UMLS CUI [3,1])
C1517586 (UMLS CUI [3,2])
Systemic Chemotherapy | Methotrexate High dose | Cytarabine High dose | Thiotepa High dose | Blood - brain barrier Involved
Item
concurrent systemic chemotherapy with high dose methotrexate, high dose cytarabine, or high dose thiotepa (they cross the blood brain barrier at high levels)
boolean
C1883256 (UMLS CUI [1])
C0025677 (UMLS CUI [2,1])
C0444956 (UMLS CUI [2,2])
C0010711 (UMLS CUI [3,1])
C0444956 (UMLS CUI [3,2])
C0039871 (UMLS CUI [4,1])
C0444956 (UMLS CUI [4,2])
C0005854 (UMLS CUI [5,1])
C1314939 (UMLS CUI [5,2])
Whole brain radiotherapy | Craniospinal Irradiation
Item
patients receiving whole brain radiotherapy or craniospinal irradiation
boolean
C1520143 (UMLS CUI [1])
C3494227 (UMLS CUI [2])
Malignant Neoplasm Site | Carcinoma in situ of uterine cervix Treated | Basal cell carcinoma Treated | Squamous cell carcinoma of skin Treated | Prostate carcinoma Chemotherapy Unnecessary
Item
previous (less than 2 years from diagnosis) or concurrent malignancies at other sites with the exception of fully treated carcinoma in situ of the cervix, basal cell carcinoma of the skin, and squamous cell carcinoma of the skin, or prostate cancer not requiring ongoing chemotherapy
boolean
C0006826 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C0851140 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0007117 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0553723 (UMLS CUI [4,1])
C1522326 (UMLS CUI [4,2])
C0600139 (UMLS CUI [5,1])
C0392920 (UMLS CUI [5,2])
C1710572 (UMLS CUI [5,3])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
meninges; infection
Item
known active meningeal infection
boolean
C1400607 (UMLS CUI [1])
Obstructive Hydrocephalus Requirement Neurosurgical Procedures
Item
evidence of obstructive hydrocephalus requiring neurosurgical intervention
boolean
C0549423 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0524850 (UMLS CUI [1,3])