age
Item
age 18 - 75 years
boolean
C0001779 (UMLS CUI [1])
hbv hcc
Item
hbv carrier with hcc
boolean
C0019163 (UMLS CUI [1,1])
C2239176 (UMLS CUI [1,2])
hcc percutaneous radiofrequency ablation
Item
after percutaneous radiofrequency ablation;
boolean
C2239176 (UMLS CUI [1,1])
C2052891 (UMLS CUI [1,2])
encephalopathy, ascites refractory to diuretics, variceal bleeding
Item
no history of encephalopathy, ascites refractory to diuretics or variceal bleeding
boolean
C0085584 (UMLS CUI [1])
C0003962 (UMLS CUI [2,1])
C0012798 (UMLS CUI [2,2])
C0333106 (UMLS CUI [3])
hcv, hiv
Item
no hcv or hiv co-infection
boolean
C0220847 (UMLS CUI [1])
C0019682 (UMLS CUI [2])
hcc treatment
Item
no previous treatment of hcc
boolean
C2239176 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
hbv treatment, lamivudine
Item
no previous treatment of hbv except lamivudine
boolean
C0019163 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0209738 (UMLS CUI [1,3])
compliance
Item
patient compliance is poor
boolean
C1321605 (UMLS CUI [1])
serious infections
Item
active clinically serious infections ( > grade 2 national cancer institute [nci]-common terminology criteria for adverse events [ctcae] version 3.0)
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
hiv
Item
known history of human immunodeficiency virus (hiv) infection
boolean
C0019682 (UMLS CUI [1])
cns tumor or metastatic brain disease
Item
known central nervous system tumors including metastatic brain disease
boolean
C0085136 (UMLS CUI [1,1])
C0220650 (UMLS CUI [1,2])
gastrointestinal bleeding
Item
patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry
boolean
C0017181 (UMLS CUI [1])
extrahepatic metastasis
Item
distantly extrahepatic metastasis
boolean
C0027627 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
organ allograft
Item
history of organ allograft
boolean
C0040739 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
substance abuse, condition interferes with participation or result evaluation
Item
substance abuse, medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results
boolean
C0038586 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0679823 (UMLS CUI [2,3])
C0814849 (UMLS CUI [2,4])
excluded therapie and medications
Item
excluded therapies and medications, previous and concomitant
boolean
C2828389 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
systemic cancer treatment, antiviral interferon therapy
Item
prior use of any systemic anti-cancer treatment for hcc, eg. chemotherapy, immunotherapy or hormonal therapy (except that hormonal therapy for supportive care is permitted). antiviral treatment is allowed, however interferon therapy must be stopped at least 4 weeks prior randomization
boolean
C0920425 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C2363964 (UMLS CUI [2,1])
C0279030 (UMLS CUI [2,2])
investigational agents for hcc
Item
prior use of systemic investigational agents for hcc
boolean
C2239176 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
autologous bone marrow transplant or stem cell rescue
Item
autologous bone marrow transplant or stem cell rescue within four months of start of study drug
boolean
C0194037 (UMLS CUI [1,1])
C2825926 (UMLS CUI [1,2])