ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status (ps) 0-2.
boolean
C1520224 (UMLS CUI [1])
Left ventricular ejection fraction Normal
Item
normal left ventricular ejection fraction (lvef).
boolean
C0428772 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
Age
Item
age ≤ 65 years.
boolean
C0001779 (UMLS CUI [1])
Measurable Disease Linear Quantity Imaging study
Item
at least one unidimensionally measurable lesion by imaging studies.
boolean
C1513041 (UMLS CUI [1,1])
C0205132 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1881134 (UMLS CUI [1,4])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Secondary malignant neoplasm of liver
Item
ast/alt 2.5 uln (< 5 uln if liver metastases).
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
C0494165 (UMLS CUI [3])
Serum total bilirubin measurement | Creatinine measurement, serum
Item
serum bilirubin 3 uln, serum creatinine 1.5 uln.
boolean
C1278039 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Proteinuria Urine dipstick test
Item
urine dipstick of proteinuria <2+.
boolean
C0033687 (UMLS CUI [1,1])
C0430370 (UMLS CUI [1,2])
Childbearing Potential Serum pregnancy test negative
Item
women of childbearing potential must have a negative serum pregnancy test.
boolean
C3831118 (UMLS CUI [1,1])
C0430061 (UMLS CUI [1,2])
Uncontrolled hypertension | Systolic Pressure | Diastolic blood pressure
Item
uncontrolled hypertension (systolic blood pressure > 160 mm hg, diastolic blood pressure > 90 mm hg).
boolean
C1868885 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
Bevacizumab Exposure to
Item
prior exposure to bevacizumab.
boolean
C0796392 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
Therapeutic radiology procedure Planned Comorbidity | Prior radiation therapy Completed | Secondary malignant neoplasm of bone Excluded
Item
planned radiotherapy for underlying disease (prior completed radiotherapy treatment allowed), except bone metastasis.
boolean
C1522449 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
C0279134 (UMLS CUI [2,1])
C0205197 (UMLS CUI [2,2])
C0153690 (UMLS CUI [3,1])
C2828389 (UMLS CUI [3,2])
Bleeding tendency Evidence of | Blood Coagulation Disorder Evidence of
Item
evidence of bleeding diathesis or coagulopathy.
boolean
C1458140 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C0005779 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
Cardiovascular Diseases | Cerebrovascular accident | Myocardial Infarction | Angina, Unstable | Congestive heart failure New York Heart Association Classification | Cardiac Arrhythmia Serious Requirement Pharmaceutical Preparations
Item
clinically significant (i.e. active) cardiovascular disease for example cerebrovascular accidents (≤ 6 months), myocardial infarction (≤ 6 months), unstable angina, new york heart association (nyha) grade ii or greater congestive heart failure, serious cardiac arrhythmia requiring medication. stroke in the preceding six months.
boolean
C0007222 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0002965 (UMLS CUI [4])
C0018802 (UMLS CUI [5,1])
C1275491 (UMLS CUI [5,2])
C0003811 (UMLS CUI [6,1])
C0205404 (UMLS CUI [6,2])
C1514873 (UMLS CUI [6,3])
C0013227 (UMLS CUI [6,4])
Disease Evidence of | Impaired metabolic functioning | Physical Examination | Laboratory Results | Medical contraindication Bevacizumab | Medical contraindication Chemotherapy
Item
evidence of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates use of bevacizumab with chemotherapy.
boolean
C0012634 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C4062541 (UMLS CUI [2])
C0031809 (UMLS CUI [3])
C1254595 (UMLS CUI [4])
C1301624 (UMLS CUI [5,1])
C0796392 (UMLS CUI [5,2])
C1301624 (UMLS CUI [6,1])
C0392920 (UMLS CUI [6,2])
Aspirin U/day | Pharmaceutical Preparations Predisposition Gastrointestinal ulceration
Item
ongoing treatment with aspirin (> 325 mg/day) or other medications known to predispose to gastrointestinal ulceration.
boolean
C0004057 (UMLS CUI [1,1])
C0456683 (UMLS CUI [1,2])
C0013227 (UMLS CUI [2,1])
C0220898 (UMLS CUI [2,2])
C1963975 (UMLS CUI [2,3])
Pregnancy Serum pregnancy test positive | Breast Feeding | Illness Serious Study Subject Participation Status Inappropriate | Illness Uncontrolled Study Subject Participation Status Inappropriate
Item
pregnancy (positive serum pregnancy test) and lactation. any other serious or uncontrolled illness which, in the opinion of the investigator, makes it undesirable for the patient to enter the trial.
boolean
C0032961 (UMLS CUI [1,1])
C0430063 (UMLS CUI [1,2])
C0006147 (UMLS CUI [2])
C0221423 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C1548788 (UMLS CUI [3,4])
C0221423 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C2348568 (UMLS CUI [4,3])
C1548788 (UMLS CUI [4,4])