Informed Consent
Item
ability and willingness to provide written informed consent
boolean
C0021430 (UMLS CUI [1])
Major Depressive Disorder Primary
Item
primary diagnosis of major depressive disorder (mdd)
boolean
C1269683 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
Age
Item
age 18-45
boolean
C0001779 (UMLS CUI [1])
Hamilton Depression Rating Scale 17 Item Questionnaire | Clinical Global Impression Questionnaire
Item
screening and baseline hamilton rating scale for depression (hrsd) 17-item score greater than or equal to 16 or clinical global impression (cgi) score of at least 4
boolean
C3639712 (UMLS CUI [1])
C3639708 (UMLS CUI [2])
Impaired cognition | Concentration ability impaired
Item
subjective report of difficulties with cognition and/or concentration and score of 2 or greater on the inventory for depressive symptomatology (ids-c(30)) item addressing this symptom (#16: concentration and decision making)
boolean
C0338656 (UMLS CUI [1])
C0858201 (UMLS CUI [2])
Comorbidity Laboratory Procedures | Comorbidity Information Physician | Comorbidity Evidence Physical Examination
Item
presence of significant comorbid condition based on laboratory tests, physician information, or evidence at examination
boolean
C0009488 (UMLS CUI [1,1])
C0022885 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2,1])
C1533716 (UMLS CUI [2,2])
C0031831 (UMLS CUI [2,3])
C0009488 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])
C0031809 (UMLS CUI [3,3])
Liver disease Patient report | Liver disease Evidence Physical Examination | Liver disease Evidence Laboratory Procedures
Item
patient report or evidence (based on physical examination or laboratory tests) of existing liver disease
boolean
C0023895 (UMLS CUI [1,1])
C0747307 (UMLS CUI [1,2])
C0023895 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C0031809 (UMLS CUI [2,3])
C0023895 (UMLS CUI [3,1])
C3887511 (UMLS CUI [3,2])
C0022885 (UMLS CUI [3,3])
Mental disorders | Depressive disorder Due to Comorbidity | Suicidal | High suicide risk | Psychotic Disorders | Bipolar I disorder | Bipolar II disorder | Bipolar Disorder | Schizophrenia | Schizoaffective Disorder | Anorexia | Bulimia | Obsessive-Compulsive Disorder | Substance Use Disorders | Medical contraindication Relative Duloxetine | Medical contraindication Absolute Duloxetine
Item
presence of other psychological disorders, including depression due to other comorbid conditions, currently suicidal or high suicide risk, current or past psychotic disorders of any type, bipolar disorder (i, ii, or nos), schizophrenia, or schizoaffective disorder, anorexia, bulimia, obsessive compulsive disorder, alcohol or substance abuse within the last 6 months, or patients with comorbid psychiatric conditions that are relative or absolute contraindications to the use of duloxetine
boolean
C0004936 (UMLS CUI [1])
C0011581 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0009488 (UMLS CUI [2,3])
C0438696 (UMLS CUI [3])
C1271074 (UMLS CUI [4])
C0033975 (UMLS CUI [5])
C0853193 (UMLS CUI [6])
C0236788 (UMLS CUI [7])
C0005586 (UMLS CUI [8])
C0036341 (UMLS CUI [9])
C0036337 (UMLS CUI [10])
C0003123 (UMLS CUI [11])
C0006370 (UMLS CUI [12])
C0028768 (UMLS CUI [13])
C0038586 (UMLS CUI [14])
C1301624 (UMLS CUI [15,1])
C0205345 (UMLS CUI [15,2])
C0245561 (UMLS CUI [15,3])
C1301624 (UMLS CUI [16,1])
C0205344 (UMLS CUI [16,2])
C0245561 (UMLS CUI [16,3])
Pharmacotherapy | Psychotherapy | Antidepressive Agents | Anti-Anxiety Agents | Antipsychotic Agents | Mood Stabilizer | Cognitive Therapy | Medical contraindication duloxetine
Item
concomitant pharmacological or psychotherapeutic treatment including but not limited to antidepressants, anxiolytics, neuroleptics, mood stabilizers, and/or other agents without proven antidepressant efficacy, cognitive behavioral therapy; current use of other medications that would be contraindicated with duloxetine, as determined by the study doctor
boolean
C0013216 (UMLS CUI [1])
C0033968 (UMLS CUI [2])
C0003289 (UMLS CUI [3])
C0040616 (UMLS CUI [4])
C0040615 (UMLS CUI [5])
C2917435 (UMLS CUI [6])
C0009244 (UMLS CUI [7])
C1301624 (UMLS CUI [8,1])
C0245561 (UMLS CUI [8,2])
Hospitalization Mental disorder
Item
hospitalization for mental illness within the past year
boolean
C0019993 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
Ability to speak fluently English Language | Able to write English Language
Item
not fluent in spoken and written english
boolean
C0564240 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0584993 (UMLS CUI [2,1])
C0376245 (UMLS CUI [2,2])
Pregnancy | Pregnancy, Planned | Breast Feeding
Item
for women, currently pregnant, planning to become pregnant in the next year, or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
C0006147 (UMLS CUI [3])