Major Depressive Disorder
Item
meet diagnostic criteria for current major depressive disorder
boolean
C1269683 (UMLS CUI [1])
Age
Item
men or women aged 18-65
boolean
C0001779 (UMLS CUI [1])
Pharmaceutical Preparations Free of
Item
medication-free for one week prior to the start of the study
boolean
C0013227 (UMLS CUI [1,1])
C0332296 (UMLS CUI [1,2])
Contraceptive methods Agree
Item
agrees to use an effective form of contraception throughout the study
boolean
C0700589 (UMLS CUI [1,1])
C3641827 (UMLS CUI [1,2])
Inclusion criteria Healthy Volunteers
Item
inclusion criteria (healthy volunteers):
boolean
C1512693 (UMLS CUI [1,1])
C1708335 (UMLS CUI [1,2])
Age
Item
men or women aged 18-65
boolean
C0001779 (UMLS CUI [1])
Pharmaceutical Preparations Free of
Item
medication-free for one week prior to the start of the study
boolean
C0013227 (UMLS CUI [1,1])
C0332296 (UMLS CUI [1,2])
Contraceptive methods Agree
Item
agrees to use an effective form of contraception throughout the study
boolean
C0700589 (UMLS CUI [1,1])
C3641827 (UMLS CUI [1,2])
Suicidal
Item
anyone who is suicidal
boolean
C0438696 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Illness Serious | Illness Unstable | Cardiovascular Disease | Liver disease | Kidney Disease | Respiration Disorder | Endocrine System Disease | nervous system disorder | Hematological Disease
Item
anyone with a serious or unstable medical illness, including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0221423 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0007222 (UMLS CUI [3])
C0023895 (UMLS CUI [4])
C0022658 (UMLS CUI [5])
C0035204 (UMLS CUI [6])
C0014130 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0018939 (UMLS CUI [9])
Epilepsy | Hypothyroidism
Item
anyone with a history of seizure disorder or hypothyroidism
boolean
C0014544 (UMLS CUI [1])
C0020676 (UMLS CUI [2])
Mental disorders | Bipolar Disorder | Schizophrenia | Psychotic Disorders | Substance Use Disorders
Item
anyone with a history of psychiatric disorders including bipolar disorder, schizophrenia, psychoses, or substance abuse (including alcohol abuse active within the last 12 months)
boolean
C0004936 (UMLS CUI [1])
C0005586 (UMLS CUI [2])
C0036341 (UMLS CUI [3])
C0033975 (UMLS CUI [4])
C0038586 (UMLS CUI [5])
intolerance to substance | Adverse reaction to drug multiple | Citalopram allergy | Hypersensitivity Escitalopram
Item
anyone with a history of intolerance or multiple adverse drug reactions or allergy to (es)citalopram.
boolean
C1744706 (UMLS CUI [1])
C0041755 (UMLS CUI [2,1])
C0439064 (UMLS CUI [2,2])
C0570769 (UMLS CUI [3])
C0020517 (UMLS CUI [4,1])
C1099456 (UMLS CUI [4,2])
GABA | Benzodiazepines
Item
patients who are currently taking medications active on gaba, including benzodiazepines.
boolean
C0016904 (UMLS CUI [1])
C0005064 (UMLS CUI [2])