Aggressive Non-Hodgkin Lymphoma untreated | Lymphoma, Large-Cell, Follicular | adult diffuse large cell lymphoma | Peripheral T-Cell Lymphoma | Lymphoma Transformed | Lymphoblastic lymphoma | Burkitt Lymphoma | Burkitt-like lymphoma
Item
patients with previously untreated aggressive non-hodgkin's lymphoma. aggressive histologies include follicular large cell, diffuse large cell, peripheral t cell, transformed lymphomas, lymphoblastic lymphomas, burkitt and burkitt like lymphomas.
boolean
C1332225 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0079745 (UMLS CUI [2])
C0278762 (UMLS CUI [3])
C0079774 (UMLS CUI [4])
C0024299 (UMLS CUI [5,1])
C0457344 (UMLS CUI [5,2])
C0079748 (UMLS CUI [6])
C0006413 (UMLS CUI [7])
C1368771 (UMLS CUI [8])
Measurable Disease | Evaluable Disease
Item
must have measurable or evaluable disease.
boolean
C1513041 (UMLS CUI [1])
C1516986 (UMLS CUI [2])
Ann Arbor lymphoma staging system
Item
stage i-iv patients are eligible
boolean
C0432516 (UMLS CUI [1])
Age
Item
patients must be 18 years or older.
boolean
C0001779 (UMLS CUI [1])
Neurosensory impairment CTCAE Grades | Neuromuscular Dysfunction CTCAE Grades
Item
no evidence of grade 3 or more neurosensory or neuromotor dysfunction (see appendix-
boolean
C4062958 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0597054 (UMLS CUI [2,1])
C3887504 (UMLS CUI [2,2])
C1516728 (UMLS CUI [2,3])
Toxicity criteria
Item
toxicity criteria)
boolean
C0600688 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
Informed Consent
Item
written consent
boolean
C0021430 (UMLS CUI [1])
HIV Seropositivity | Hepatitis B | Hepatitis C
Item
hiv positive patients and those with hepatitis b or c will be excluded from this protocol.
boolean
C0019699 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Bone Marrow function Inadequate | Organ function Inadequate
Item
patients with inadequate bone marrow and organ function as defined below:
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0205412 (UMLS CUI [1,3])
C0678852 (UMLS CUI [2,1])
C0205412 (UMLS CUI [2,2])
Absolute neutrophil count
Item
neutrophils <1,000/l
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
platelets <100,000/l
boolean
C0032181 (UMLS CUI [1])
Serum total bilirubin measurement
Item
billirubin >2
boolean
C1278039 (UMLS CUI [1])
Creatinine measurement, serum | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
creatinine >2.0 or estimated crcl <30 cc/min
boolean
C0201976 (UMLS CUI [1])
C2711451 (UMLS CUI [2])
Central nervous system lymphoma
Item
cns involvement by lymphoma.
boolean
C0742472 (UMLS CUI [1])
Comorbidity Uncontrolled | Cardiac Arrhythmia | Angina Pectoris | Congestive heart failure New York Heart Association Classification | Symptomatic congestive heart failure At rest | Communicable Disease
Item
uncontrolled intercurrent disease including arrhythmias, angina pectoris, class iii-iv congestive heart failure (chf symptoms on less than ordinary exertion or at rest) or active infection.
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0003811 (UMLS CUI [2])
C0002962 (UMLS CUI [3])
C0018802 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0742758 (UMLS CUI [5,1])
C0443144 (UMLS CUI [5,2])
C0009450 (UMLS CUI [6])
Communicable Disease | Fever Degrees Celsius | Communicable Disease Due to Lymphoma | Fever Due to Lymphoma
Item
active infection or fever > 38.2 degrees c unless due to lymphoma.
boolean
C0009450 (UMLS CUI [1])
C0015967 (UMLS CUI [2,1])
C0439237 (UMLS CUI [2,2])
C0009450 (UMLS CUI [3,1])
C0678226 (UMLS CUI [3,2])
C0024299 (UMLS CUI [3,3])
C0015967 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C0024299 (UMLS CUI [4,3])
Contraceptive methods Lacking
Item
subject is not using adequate contraceptive precautions.
boolean
C0700589 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnancy or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])