Age
Item
ages 18 years and older
boolean
C0001779 (UMLS CUI [1])
Chronic Lymphocytic Leukemia | Blood--Examination Peripheral | Bone Marrow Examination | Criteria Standard
Item
diagnosis of cll established by peripheral blood and bone marrow examination and using the standard criteria
boolean
C0023434 (UMLS CUI [1])
C3826648 (UMLS CUI [2,1])
C0205100 (UMLS CUI [2,2])
C0005957 (UMLS CUI [3])
C0243161 (UMLS CUI [4,1])
C1442989 (UMLS CUI [4,2])
Rai Staging System | Lymphadenopathy massive Symptomatic | Therapeutic procedure Patient need for
Item
patients with rai stage iii or iv, or earlier stage with massive, symptomatic lymphadenopathy requiring therapy
boolean
C1514715 (UMLS CUI [1])
C0235599 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0087111 (UMLS CUI [3,1])
C0686904 (UMLS CUI [3,2])
Therapeutic procedure Fludarabine Based | Resistance Primary | Complete response Absent | Partial response Absent | Progressive Disease
Item
primary resistance to fludarabine-based therapy (no complete response [cr] or partial response [pr]) or progressive disease within 6 months of response to prior fludarabine containing regimen.
boolean
C0087111 (UMLS CUI [1,1])
C0059985 (UMLS CUI [1,2])
C1705938 (UMLS CUI [1,3])
C1514892 (UMLS CUI [2,1])
C0205225 (UMLS CUI [2,2])
C0677874 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C1521726 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C1335499 (UMLS CUI [5])
ECOG performance status
Item
ecog performance status of 0, 1, 2 or 3
boolean
C1520224 (UMLS CUI [1])
Contraceptive methods | Latex condom | CERVICAL CAP FOR CONTRACEPTIVE USE | Vaginal contraceptive diaphragm | Sexual Abstinence
Item
willing to take adequate contraception (i.e. latex condom, cervical cap, diaphragm, abstinence, etc.) for the entire duration of the study and 3 months after
boolean
C0700589 (UMLS CUI [1])
C3873750 (UMLS CUI [2])
C0493327 (UMLS CUI [3])
C0042241 (UMLS CUI [4])
C0036899 (UMLS CUI [5])
Investigational Therapies Discontinued
Item
all investigational treatments should have been discontinued for at least 1 week prior to the initiation of the study drug.
boolean
C0949266 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or nursing
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Informed Consent Unable | Informed Consent Unwilling
Item
unable or unwilling to sign consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
Comorbidity Severe | Investigational Therapy Excluded
Item
severe, ongoing co-morbid conditions, which would preclude safe delivery of the investigational therapy
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0949266 (UMLS CUI [2,1])
C2828389 (UMLS CUI [2,2])
Communicable Diseases Serious Uncontrolled | Antibiotics
Item
active serious infections that are not controlled by antibiotics
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0003232 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status 4
boolean
C1520224 (UMLS CUI [1])
Abnormal renal function | Creatinine measurement, serum | Serum creatinine measurement Disease Related
Item
inadequate renal function: creatinine 2.0 or more unless related to the disease
boolean
C0151746 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C0201976 (UMLS CUI [3,1])
C0012634 (UMLS CUI [3,2])
C0439849 (UMLS CUI [3,3])
Liver function abnormal | Serum total bilirubin measurement | Transaminases increased | Transaminases increased Disease Related
Item
inadequate liver function: bilirubin 3.0 or more, transaminases 3 x upper limit of normal or more unless related to the disease
boolean
C0151766 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0438717 (UMLS CUI [3])
C0438717 (UMLS CUI [4,1])
C0012634 (UMLS CUI [4,2])
C0439849 (UMLS CUI [4,3])
HIV Seropositivity
Item
known positive test for hiv
boolean
C0019699 (UMLS CUI [1])
Hepatitis B | Hepatitis C
Item
patients with known hepatitis b and/or hepatitis c active infection
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])