Acute Myelocytic Leukemia WHO classification | Acute Myelocytic Leukemia French-American-British Classification | Blast count
Item
1. diagnosis of 1) aml (who classification definition of >/= 20% blasts). patients with m6 aml with less than 20% blasts are eligible.
boolean
C0023467 (UMLS CUI [1,1])
C1301142 (UMLS CUI [1,2])
C0023467 (UMLS CUI [2,1])
C2984084 (UMLS CUI [2,2])
C0523113 (UMLS CUI [3])
Age | Chemotherapy naive | Acute Myelocytic Leukemia | Hydrea | Blood Transfusion | Hematopoietic Growth Factors | Vitamins | Pheresis
Item
2. patients aged 15 to 75 years are eligible. patients must be chemo-naïve, i.e. not have received any prior chemotherapy (except hydrea) for aml. they could have received transfusions, hematopoietic growth factors or vitamins. temporary measures such as pheresis or hydrea (0.5 to 5g daily or more for up to 3 days) are allowed .
boolean
C0001779 (UMLS CUI [1])
C0392920 (UMLS CUI [2,1])
C0919936 (UMLS CUI [2,2])
C0023467 (UMLS CUI [3])
C0591617 (UMLS CUI [4])
C0005841 (UMLS CUI [5])
C0079490 (UMLS CUI [6])
C0042890 (UMLS CUI [7])
C0005791 (UMLS CUI [8])
ECOG performance status
Item
3. ecog ps of 0, 1, 2, or 3 at screening.
boolean
C1520224 (UMLS CUI [1])
Biochemical finding | Creatinine measurement, serum
Item
4. serum biochemical values with the following limits: - creatinine </= 2.0 mg/dl -
boolean
C0428132 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Serum total bilirubin measurement
Item
total bilirubin </= 2.0 mg/dl, unless increase is due to hemolysis - transaminases (sg pt) </= 3x uln
boolean
C1278039 (UMLS CUI [1])
Informed Consent
Item
5. ability to understand and provide signed informed consent.
boolean
C0021430 (UMLS CUI [1])
Acute Promyelocytic Leukemia
Item
1. subjects with acute promyelocytic leukemia (apl).
boolean
C0023487 (UMLS CUI [1])
Sepsis
Item
2. presence of active systemic infection.
boolean
C0243026 (UMLS CUI [1])
Comorbidity Interferes with Protocol Compliance | Comorbidity Interferes with Research results
Item
3. any coexisting medical condition that in the judgment of the treating physician is likely to interfere with study procedures or results.
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0683954 (UMLS CUI [2,3])
Breast Feeding | Urine pregnancy test positive | Childbearing Potential Contraceptive methods Unwilling | Contraceptives, Oral | Intrauterine Devices | Vaginal contraceptive diaphragm | Sexual Abstinence | Condoms Partner
Item
4. nursing women, women of childbearing potential with positive urine pregnancy test, or women of childbearing potential who are not willing to maintain adequate contraception (such as birth control pills, iud, diaphragm, abstinence, or condoms by their partner) over the entire course of the study.
boolean
C0006147 (UMLS CUI [1])
C0430059 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0558080 (UMLS CUI [3,3])
C0009905 (UMLS CUI [4])
C0021900 (UMLS CUI [5])
C0042241 (UMLS CUI [6])
C0036899 (UMLS CUI [7])
C0677582 (UMLS CUI [8,1])
C0682323 (UMLS CUI [8,2])