Leukemia Recurrent | Leukemia refractory | Leukemia, Myelocytic, Acute | Acute lymphocytic leukemia | Chronic Lymphocytic Leukemia | Blast Phase | Standard therapy Remission Durable | Myelodysplasia Low Risk | Refractory anaemia with excess blasts | Refractory anemia with excess blasts in transformation | Leukemia, Myelomonocytic, Chronic | Patients Recurrent disease | Patients Unresponsive to Treatment | refusing treatment | Patients Ineligible Therapeutic procedure
Item
relapsed/refractory leukemias including acute non-lymphocytic leukemia (aml), acute lymphocytic leukemia (all), chronic lymphocytic leukemia (cll), and chronic myelogenous leukemia in blastic phase (cml-bp) for which no standard therapies are anticipated to result in a durable remission; or poor-risk myelodysplasia (mds) patients to include refractory anemia with excess blasts (raeb) or excess blasts in transformation (raebt) and chronic myelomonocytic leukemia (cmml) who are either relapsed/refractory or who refuse/are not eligible for frontline therapy.
boolean
C0023418 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C0023418 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C0023467 (UMLS CUI [3])
C0023449 (UMLS CUI [4])
C0023434 (UMLS CUI [5])
C0005699 (UMLS CUI [6])
C2936643 (UMLS CUI [7,1])
C0544452 (UMLS CUI [7,2])
C0449238 (UMLS CUI [7,3])
C0026985 (UMLS CUI [8,1])
C3538919 (UMLS CUI [8,2])
C0002894 (UMLS CUI [9])
C0280028 (UMLS CUI [10])
C0023480 (UMLS CUI [11])
C0030705 (UMLS CUI [12,1])
C0277556 (UMLS CUI [12,2])
C0030705 (UMLS CUI [13,1])
C0205269 (UMLS CUI [13,2])
C0749657 (UMLS CUI [14])
C0030705 (UMLS CUI [15,1])
C1512714 (UMLS CUI [15,2])
C0087111 (UMLS CUI [15,3])
Acute lymphocytic leukemia refractory | Chronic myeloid leukemia in lymphoid blast crisis
Item
only patients with refractory all or cml in lymphoid blastic phase are eligible for phase ii.
boolean
C0023449 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
C1531551 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status 0 - 2.
boolean
C1520224 (UMLS CUI [1])
Organ function | Mature Neutrophils Present Bone Marrow Complete
Item
adequate organ function and bone marrow reserve.
boolean
C0678852 (UMLS CUI [1])
C1708947 (UMLS CUI [2,1])
C0005953 (UMLS CUI [2,2])
C0205197 (UMLS CUI [2,3])
major surgery
Item
at least 4 weeks must have elapsed from the time of major surgery.
boolean
C0679637 (UMLS CUI [1])
Contraceptive methods Use of
Item
use of appropriate contraceptive method.
boolean
C0700589 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
Informed Consent
Item
signed patient informed consent.
boolean
C0021430 (UMLS CUI [1])
HIV
Item
known human immunodeficiency virus (hiv).
boolean
C0019682 (UMLS CUI [1])
Heart Disease | Myocardial Infarction | Coronary Artery Disease Symptomatic | Cardiac Arrhythmia Uncontrolled | Congestive heart failure Uncontrolled
Item
active heart disease including myocardial infarction within previous 3 months, symptomatic coronary artery disease, arrhythmias not controlled by medication, or uncontrolled congestive heart failure.
boolean
C0018799 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C1956346 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C0003811 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C0018802 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
Standard therapy Leukemia | Investigational Therapy Leukemia | Adrenal Cortex Hormones | hydroxyurea | mercaptopurine
Item
patients receiving any other standard or investigational treatment for their leukemia other than corticosteriods, hydroxyurea, and 6-mercaptopurine.
boolean
C2936643 (UMLS CUI [1,1])
C0023418 (UMLS CUI [1,2])
C0949266 (UMLS CUI [2,1])
C0023418 (UMLS CUI [2,2])
C0001617 (UMLS CUI [3])
C0020402 (UMLS CUI [4])
C0000618 (UMLS CUI [5])
Medical condition High risk of Toxicity
Item
any medical condition which, in the opinion of the investigator, places the patient at an unacceptably high risk for toxicities.
boolean
C3843040 (UMLS CUI [1,1])
C0332167 (UMLS CUI [1,2])
C0600688 (UMLS CUI [1,3])