age
Item
1. age over 18 years.
boolean
C0001779 (UMLS CUI [1])
informed consent
Item
2. signed informed consent.
boolean
C0021430 (UMLS CUI [1])
colorectal adenocarcinoma
Item
3. histologically proven colorectal adenocarcinoma
boolean
C1319315 (UMLS CUI [1])
colorectal cancer stage IV
Item
4. history or presence of metastatic colorectal cancer (stage iv)
boolean
C0677950 (UMLS CUI [1])
measurable tumor
Item
5. measurable (>1 cm) or evaluable tumour deposit (according to recist criteria)
boolean
C1302351 (UMLS CUI [1])
tumor progression or toxicity on therapy
Item
6. documented progression or unacceptable toxicity on the last therapy
boolean
C0178874 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0013221 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
tumor progression or neurotoxicity on oxliplatin
Item
7. progression on oxaliplatin-based chemotherapy or unacceptable residual neurotoxicity on oxaliplatin
boolean
C0069717 (UMLS CUI [1,1])
C0178874 (UMLS CUI [1,2])
C0069717 (UMLS CUI [2,1])
C0235032 (UMLS CUI [2,2])
tumor progression or toxicity on irinotecan
Item
8. progression on irinotecan-based chemotherapy or unacceptable toxicity on irinotecan
boolean
C0123931 (UMLS CUI [1,1])
C0178874 (UMLS CUI [1,2])
C0123931 (UMLS CUI [2,1])
C0013221 (UMLS CUI [2,2])
tumor progression or toxicity on egfr inhibitor
Item
9. if patients have been previously exposed to cetuximab or other egfr inhibitor, they must have shown progression or unacceptable toxicity
boolean
C1443775 (UMLS CUI [1,1])
C0178874 (UMLS CUI [1,2])
C1443775 (UMLS CUI [2,1])
C0013221 (UMLS CUI [2,2])
tumor progression or toxicity on bevacizumab
Item
10. if patients have been previously exposed to bevacizumab or other vegf inhibitor, they must have shown progression or unacceptable toxicity
boolean
C0796392 (UMLS CUI [1,1])
C0178874 (UMLS CUI [1,2])
C0796392 (UMLS CUI [2,1])
C0013221 (UMLS CUI [2,2])
life expectancy
Item
11. life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1])
ecog performance status
Item
12. who (ecog) performance status <= 2, <= 1 if age > 75 years.
boolean
C1520224 (UMLS CUI [1])
hepatic function
Item
13. adequate hepatic function
boolean
C0232741 (UMLS CUI [1])
renal function
Item
14. adequate renal function
boolean
C0232804 (UMLS CUI [1])
egfr, her2 or vegfr tyrosine kinase inhibitors
Item
1. prior treatment with small molecule egfr, her2 or vegfr tyrosine kinase inhibitors
boolean
C1443775 (UMLS CUI [1])
C1268567 (UMLS CUI [2])
C2985521 (UMLS CUI [3])
chemotherapy, cetuximab
Item
2. treatment with standard chemotherapy or cetuximab within the last 14 days
boolean
C0392920 (UMLS CUI [1])
C0995188 (UMLS CUI [2])
bevacizumab
Item
3. treatment with bevacizumab within the last 28 days
boolean
C0796392 (UMLS CUI [1])
other malignancies affecting compliance
Item
4. history of other malignancies in the last 5 years, which could affect compliance with the protocol or interpretation of results. patients with adequately treated basal or squamous cell skin cancer are generally eligible.
boolean
C0006826 (UMLS CUI [1,1])
C1321605 (UMLS CUI [1,2])
neurologic, psychiatric, infectious or ulcer comorbidities or laboratory abnormality
Item
5. serious illness or concomitant non-oncological disease such as neurologic, psychiatric, infectious disease or active ulcers (gastro-intestinal tract, skin) or laboratory abnormality
boolean
C0009488 (UMLS CUI [1,1])
C0027765 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2,1])
C0004936 (UMLS CUI [2,2])
C0009488 (UMLS CUI [3,1])
C0009450 (UMLS CUI [3,2])
C0009488 (UMLS CUI [4,1])
C0041582 (UMLS CUI [4,2])
C0009488 (UMLS CUI [5])
cardiovascular diseases
Item
6. significant cardiovascular diseases
boolean
C0007222 (UMLS CUI [1])
haemorrhage or thrombosis
Item
7. history of haemorrhagic or thrombotic event in the past 12 months. known inherited predisposition to bleeds or to thrombosis.
boolean
C0019080 (UMLS CUI [1])
C0040053 (UMLS CUI [2])
cns disease or brain metastases
Item
8. patient with history or clinical or radiological evidence of cns disease or brain metastases.
boolean
C0007682 (UMLS CUI [1])
C0220650 (UMLS CUI [2])
pregnancy, breast feeding
Item
9. pregnancy or breast-feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])