Age
Item
greater than or equal to 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Sitting systolic blood pressure mean | Sitting diastolic blood pressure mean | Run-in Period Placebo Single-Blind
Item
patients with a mean seated systolic blood pressure (mssbp) greater than or equal to 140 mmhg but less than or equal to 179 mmhg and a mean seated diastolic blood pressure (msdbp) less than or equal to 109 mmhg following a 3 to 4-week single-blind placebo run-in period.
boolean
C1319893 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
C1319894 (UMLS CUI [2,1])
C0444504 (UMLS CUI [2,2])
C3274438 (UMLS CUI [3,1])
C1696465 (UMLS CUI [3,2])
C0037181 (UMLS CUI [3,3])
Sitting systolic blood pressure mean Timepoint Difference
Item
the difference in mssbp between visits 3 and 4 or between visits 4 and 4x must be less than or equal to 10 mmhg.
boolean
C1319893 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
C2348792 (UMLS CUI [1,3])
C1705242 (UMLS CUI [1,4])
Systolic Pressure mean Daytime | Diastolic blood pressure mean Daytime | Blood Pressure Monitoring, Ambulatory | Run-in Period Placebo
Item
patients with a mean daytime (8am-4pm) systolic blood pressure (sbp) greater than or equal to 135 mmhg and less than or equal to 179 mmhg and a mean daytime diastolic blood pressure (dbp) less than or equal to 109 mmhg as measured by an ambulatory blood pressure monitoring device (abpm) following placebo run-in period.
boolean
C0871470 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
C0332169 (UMLS CUI [1,3])
C0428883 (UMLS CUI [2,1])
C0444504 (UMLS CUI [2,2])
C0332169 (UMLS CUI [2,3])
C0242876 (UMLS CUI [3])
C3274438 (UMLS CUI [4,1])
C1696465 (UMLS CUI [4,2])
Gender Serum pregnancy test negative | Postmenopausal state | Hysterectomy | Tubal Ligation | Childbearing Potential Contraceptive methods
Item
if female, must have negative serum pregnancy test at screening and be either post-menopausal (greater than or equal to 1 year), had a hysterectomy or tubal ligation at least 6 months before consent or if of childbearing potential, must practice approved measures of birth control throughout study.
boolean
C0079399 (UMLS CUI [1,1])
C0430061 (UMLS CUI [1,2])
C0232970 (UMLS CUI [2])
C0020699 (UMLS CUI [3])
C0520483 (UMLS CUI [4])
C3831118 (UMLS CUI [5,1])
C0700589 (UMLS CUI [5,2])
Cerebrovascular accident | Transient Ischemic Attack
Item
history of stroke or transient ischemic attack (tia) within the last one year.
boolean
C0038454 (UMLS CUI [1])
C0007787 (UMLS CUI [2])
Myocardial Infarction | Coronary angioplasty | Coronary Artery Bypass Surgery | Heart failure
Item
history of myocardial infarction, coronary angioplasty, coronary artery bypass graft, or heart failure within the past 6 months.
boolean
C0027051 (UMLS CUI [1])
C0190211 (UMLS CUI [2])
C0010055 (UMLS CUI [3])
C0018801 (UMLS CUI [4])
Secondary hypertension Etiology Any | Kidney Diseases | Pheochromocytoma | Cushing Syndrome
Item
patients with secondary hypertension of any etiology, such as renal disease, pheochromocytoma, or cushing's syndrome.
boolean
C0155616 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C1552551 (UMLS CUI [1,3])
C0022658 (UMLS CUI [2])
C0031511 (UMLS CUI [3])
C0010481 (UMLS CUI [4])
Insulin-Dependent Diabetes Mellitus | Non-Insulin-Dependent Diabetes Mellitus Therapeutic procedure Stable | Glucose measurement, fasting
Item
type i diabetes. patients with type ii diabetes on stable treatment, with fasting glucose <160 mg/dl may enroll.
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0202045 (UMLS CUI [3])
Heart valve disease Hemodynamic Significant
Item
patients with hemodynamically significant cardiac valvular disease.
boolean
C0018824 (UMLS CUI [1,1])
C0019010 (UMLS CUI [1,2])
C0750502 (UMLS CUI [1,3])
Conduction disorder of the heart | First degree atrioventricular block | Second degree atrioventricular block | Complete atrioventricular block | Left Bundle-Branch Block | Sick Sinus Syndrome | Atrial Fibrillation | Atrial Flutter | Accessory cardiac pathway | Cardiac Arrhythmia Requirement Pharmaceutical Preparations
Item
patients with clinically significant cardiac conduction defects, including first, second or third degree av block, left bundle branch block, sick sinus syndrome, atrial fibrillation, atrial flutter, an accessory bypass tract, or any arrhythmia requiring medication.
boolean
C0264886 (UMLS CUI [1])
C0085614 (UMLS CUI [2])
C0264906 (UMLS CUI [3])
C0151517 (UMLS CUI [4])
C0023211 (UMLS CUI [5])
C0037052 (UMLS CUI [6])
C0004238 (UMLS CUI [7])
C0004239 (UMLS CUI [8])
C1963785 (UMLS CUI [9])
C0003811 (UMLS CUI [10,1])
C1514873 (UMLS CUI [10,2])
C0013227 (UMLS CUI [10,3])