Hypertensive disease | Sitting systolic blood pressure | Age | Gender | Body Height
Item
1. previous, documented diagnosis of hypertension, or newly diagnosed hypertension according to the fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents (united states). sisbp greater than or equal to the 95th percentile for age, gender, and height.
boolean
C0020538 (UMLS CUI [1])
C1319893 (UMLS CUI [2])
C0001779 (UMLS CUI [3])
C0079399 (UMLS CUI [4])
C0005890 (UMLS CUI [5])
Antihypertensive Agents Withdraw Possible | Placebo given
Item
2. the subject can be safely withdrawn from antihypertensive medications during the screening period, and if given placebo during the treatment period in the judgment of the investigator.
boolean
C0003364 (UMLS CUI [1,1])
C2349954 (UMLS CUI [1,2])
C0332149 (UMLS CUI [1,3])
C0420256 (UMLS CUI [2])
Age | Body Weight
Item
3. the subject is male or female age 6 to 16 years (inclusive), and weighs greater than or equal to 20 kg.
boolean
C0001779 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
Age | Gender Menstruation Quantity | Serum pregnancy test negative | Breast Feeding Absent | Contraceptive methods
Item
4. female subjects greater than or equal to 12 years of age, or who have had greater than or equal to 1 menstruation must: (a) have a negative serum pregnancy test at screening (i.e., subject is not pregnant), (b) not be lactating, and (c) use an acceptable method of contraception.
boolean
C0001779 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0025344 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0430061 (UMLS CUI [3])
C0006147 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0700589 (UMLS CUI [5])
Parent Ability Home Blood Pressure Monitoring | Guardian Ability Home Blood Pressure Monitoring | Child Blood pressure monitoring | Parent Ability Administration Investigational New Drugs | Guardian Ability Administration Investigational New Drugs
Item
5. parents/guardians are able to demonstrate their ability to (a) use a home blood pressure monitor supplied for the study to monitor their child's blood pressure, and (2) mix and administer a liquid dose of study drug if needed.
boolean
C0030551 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
C1449681 (UMLS CUI [1,3])
C1274041 (UMLS CUI [2,1])
C0085732 (UMLS CUI [2,2])
C1449681 (UMLS CUI [2,3])
C0008059 (UMLS CUI [3,1])
C0026426 (UMLS CUI [3,2])
C0030551 (UMLS CUI [4,1])
C0085732 (UMLS CUI [4,2])
C1533734 (UMLS CUI [4,3])
C0013230 (UMLS CUI [4,4])
C1274041 (UMLS CUI [5,1])
C0085732 (UMLS CUI [5,2])
C1533734 (UMLS CUI [5,3])
C0013230 (UMLS CUI [5,4])
Bilateral renal artery stenosis
Item
1. bilateral renal artery stenosis.
boolean
C0856760 (UMLS CUI [1])
Aortic coarctation | Repair of coarctation of aorta | Blood pressure in right arm Blood pressure in right leg Gradient
Item
2. uncorrected coarctation of the aorta or corrected coarctation with a right arm/right leg blood pressure gradient greater than 10 mmhg.
boolean
C0003492 (UMLS CUI [1])
C0558326 (UMLS CUI [2])
C2221330 (UMLS CUI [3,1])
C2221328 (UMLS CUI [3,2])
C0812409 (UMLS CUI [3,3])
Hypertension, severe
Item
3. severe hypertension.
boolean
C4013784 (UMLS CUI [1])
Kidney Transplantation | Solid organ transplant
Item
4. renal transplantation or other previous solid organ transplantation less than 6 months prior to entering the study.
boolean
C0022671 (UMLS CUI [1])
C0730400 (UMLS CUI [2])
Nephrotic Syndrome | Maintenance therapy Stable Absent | Prednisone | Cyclosporine
Item
5. subjects with nephrotic syndrome not on stable maintenance therapy of prednisone or cyclosporine.
boolean
C0027726 (UMLS CUI [1])
C0677908 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0032952 (UMLS CUI [3])
C0010592 (UMLS CUI [4])
Cardiomyopathy | Structural disorder of heart | Atrioventricular conduction disorder | Sick Sinus Syndrome | Atrial Flutter | Atrial Fibrillation | Bradycardia | Accessory cardiac pathway | Congestive heart failure Symptoms Clinical
Item
6. a history of cardiomyopathy, clinically significant structural heart disease, or atrioventricular conduction disturbance, sick sinus syndrome, atrial flutter, atrial fibrillation, clinically significant bradycardia or an accessory bypass tract, or clinical symptoms of congestive heart failure.
boolean
C0878544 (UMLS CUI [1])
C1290384 (UMLS CUI [2])
C1627362 (UMLS CUI [3])
C0037052 (UMLS CUI [4])
C0004239 (UMLS CUI [5])
C0004238 (UMLS CUI [6])
C0428977 (UMLS CUI [7])
C1963785 (UMLS CUI [8])
C0018802 (UMLS CUI [9,1])
C1457887 (UMLS CUI [9,2])
C0205210 (UMLS CUI [9,3])
Hematological Disease | Hepatobiliary disease | Kidney Diseases | Formula Schwartz Glomerular Filtration Rate | Serum potassium measurement
Item
7. clinically significant hematologic, hepatobiliary, or renal disease including a schwartz formula gfr less than 40 ml/min/1.73 m2, and/or serum potassium (k+) greater than 5.5 meq/l.
boolean
C0018939 (UMLS CUI [1])
C0267792 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C1980037 (UMLS CUI [4,1])
C0017654 (UMLS CUI [4,2])
C0302353 (UMLS CUI [5])
Pancreatitis | Pancreatitis inactive
Item
8. history of pancreatitis (active or inactive).
boolean
C0030305 (UMLS CUI [1])
C0030305 (UMLS CUI [2,1])
C0544452 (UMLS CUI [2,2])
Angiotensin-converting-enzyme inhibitor allergy | Angioedema
Item
9. known sensitivity to angiotensin converting enzyme inhibitors or a history of angioneurotic edema.
boolean
C0571939 (UMLS CUI [1])
C0002994 (UMLS CUI [2])