Prostate carcinoma
Item
men with histologically confirmed prostate cancer
boolean
C0600139 (UMLS CUI [1])
Male Castration | Antiandrogen therapy | Gonadotropin Releasing Hormone Receptor Agonist | Gonadotropin releasing hormone antagonist
Item
bilateral orchiectomy at least 6 months before randomization or continuous androgen-deprivation therapy (adt) with a gonadotropin releasing hormone (gnrh) agonist or antagonist for at least 6 months before randomization
boolean
C0007347 (UMLS CUI [1])
C0279492 (UMLS CUI [2])
C2267073 (UMLS CUI [3])
C1268855 (UMLS CUI [4])
total serum testosterone measurement
Item
total testosterone level less than 50 ng/dl,
boolean
C2210797 (UMLS CUI [1])
Hormone refractory prostate cancer | androgen independent prostate cancer | Antiandrogen therapy | Orchiectomy Status post | Prostate specific antigen measurement Consecutive Quantity
Item
hormone refractory (androgen independent) prostate cancer demonstrated during continuous adt/post-orchiectomy defined as: 3 consecutive prostate-specific antigen (psa) values with psa1 < psa2 < psa3, each psa value must be separated by at least 2 weeks, psa2 and psa3 greater than or equal to 1.0 ng/ml,
boolean
C1328504 (UMLS CUI [1])
C1654637 (UMLS CUI [2])
C0279492 (UMLS CUI [3])
C0029189 (UMLS CUI [4,1])
C0231290 (UMLS CUI [4,2])
C0201544 (UMLS CUI [5,1])
C1707491 (UMLS CUI [5,2])
C1265611 (UMLS CUI [5,3])
Secondary malignant neoplasm of bone Development High risk | Prostate specific antigen measurement | Prostate-Specific Antigen Doubling Time
Item
high risk for development of bone metastasis defined as psa value greater than or equal to 8.0 ng/ml, obtained no more than 3 months before randomization or psa doubling time less than or equal to 10.0 months
boolean
C0153690 (UMLS CUI [1,1])
C0243107 (UMLS CUI [1,2])
C0332167 (UMLS CUI [1,3])
C0201544 (UMLS CUI [2])
C0138741 (UMLS CUI [3,1])
C2986483 (UMLS CUI [3,2])
Secondary malignant neoplasm of bone Detectable Radiography
Item
prior or current evidence of radiographically detectable bone metastasis
boolean
C0153690 (UMLS CUI [1,1])
C3830527 (UMLS CUI [1,2])
C0034571 (UMLS CUI [1,3])
Involvement metastatic Organ distant | Secondary malignant neoplasm of lymph node Region Any
Item
known prior or current evidence of any metastatic involvement of distant organs (lymph node metastases in any region is acceptable)
boolean
C1314939 (UMLS CUI [1,1])
C1522484 (UMLS CUI [1,2])
C0178784 (UMLS CUI [1,3])
C0443203 (UMLS CUI [1,4])
C0686619 (UMLS CUI [2,1])
C0005898 (UMLS CUI [2,2])
C1552551 (UMLS CUI [2,3])
Intravenous bisphosphonates Administration
Item
prior or current intravenous bisphosphonate administration
boolean
C1955566 (UMLS CUI [1,1])
C1533734 (UMLS CUI [1,2])