Liver carcinoma Inoperable intrahepatic | Liver carcinoma Inoperable Extrahepatic | Lesion of liver Dense X-Ray Computed Tomography | Elevated alpha-fetoprotein
Item
histologically verified intra- or extrahepatic inoperable hepatocellular carcinoma or hyperdense liver lesion at computed tomography and concurrent elevated alpha-feto-protein > 400 ng/ml
boolean
C2239176 (UMLS CUI [1,1])
C0205187 (UMLS CUI [1,2])
C1512948 (UMLS CUI [1,3])
C2239176 (UMLS CUI [2,1])
C0205187 (UMLS CUI [2,2])
C1517058 (UMLS CUI [2,3])
C0577053 (UMLS CUI [3,1])
C0439794 (UMLS CUI [3,2])
C0040405 (UMLS CUI [3,3])
C0235971 (UMLS CUI [4])
performance status
Item
ps 0-2
boolean
C1518965 (UMLS CUI [1])
Age
Item
age 18-75
boolean
C0001779 (UMLS CUI [1])
Life Expectancy
Item
life expectancy > 12 weeks
boolean
C0023671 (UMLS CUI [1])
Bone Marrow function | Absolute neutrophil count | Platelet Count measurement
Item
normal bone marrow function (neutrophiles > 1,5 x 109/l and platelets > 100 x 109/l)
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
Serum total bilirubin measurement
Item
bilirubin < 2 x unl
boolean
C1278039 (UMLS CUI [1])
Transaminases
Item
transaminases < 3 x unl
boolean
C0002594 (UMLS CUI [1])
Renal function | EDTA Clearance
Item
normal renal function, cr-edta clearance > 50 ml/min
boolean
C0232804 (UMLS CUI [1])
C3639405 (UMLS CUI [2])
Chemotherapy Absent | Therapeutic radiology procedure Absent | Immunotherapy Absent
Item
no chemotherapy, radiotherapy or immunotherapy 4 weeks prior to inclusion
boolean
C0392920 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0021083 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Comorbidity Severe Uncontrolled Absent
Item
no uncontrolled, severe concurrent medical disease
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0332197 (UMLS CUI [1,4])
Childbearing Potential Pregnancy test negative
Item
fertile women must have a negative pregnancy test
boolean
C3831118 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
Childbearing Potential Contraceptive methods
Item
fertile women must use adequate contraceptives during and 3 months after trial exposure
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Chemotherapy | Therapeutic radiology procedure | Immunotherapy
Item
chemotherapy, radiotherapy or immunotherapy 4 weeks prior to inclusion
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
Therapy, Investigational
Item
experimental therapy < 8 weeks prior to inclusion
boolean
C0949266 (UMLS CUI [1])
Dihydropyrimidine Dehydrogenase Deficiency
Item
known dpd-deficiency
boolean
C1959620 (UMLS CUI [1])
Neuropathy
Item
known neuropathy
boolean
C0442874 (UMLS CUI [1])
Comorbidity Severe Uncontrolled
Item
uncontrolled, severe concurrent medical disease
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
Malignant Neoplasms | Skin carcinoma | Carcinoma in situ of uterine cervix
Item
prior malignancy during the last 5 years, except for non-melanoma skin cancer and carcinoma in situ cervix uteri.
boolean
C0006826 (UMLS CUI [1])
C0699893 (UMLS CUI [2])
C0851140 (UMLS CUI [3])