Hepatitis C, Chronic | Indication Antiviral Therapy | Interferon
Item
patients with chronic hepatitis c and indication for interferon-based antiviral therapy.
boolean
C0524910 (UMLS CUI [1])
C3146298 (UMLS CUI [2,1])
C0280274 (UMLS CUI [2,2])
C3652465 (UMLS CUI [3])
Informed Consent | Clinical Study Follow-up | Adverse effects Psychiatric Long-term | Adverse effects neurocognitive Long-term | Combined Modality Therapy | Interferon Alfa-2b | Ribavirin
Item
written informed consent to study participation, especially to long-term follow-up monitoring of psychiatric and neurocognitive side effects of combination therapy with (peg)interferon alfa-2b and ribavirin.
boolean
C0021430 (UMLS CUI [1])
C3274571 (UMLS CUI [2])
C0879626 (UMLS CUI [3,1])
C0205487 (UMLS CUI [3,2])
C0443252 (UMLS CUI [3,3])
C0879626 (UMLS CUI [4,1])
C0518895 (UMLS CUI [4,2])
C0443252 (UMLS CUI [4,3])
C0009429 (UMLS CUI [5])
C0021735 (UMLS CUI [6])
C0035525 (UMLS CUI [7])
Age
Item
age of study participants: between 18 and 65 years.
boolean
C0001779 (UMLS CUI [1])
Hepatitis C Antibodies | HCV viral load Circulating | Reverse Transcriptase Polymerase Chain Reaction
Item
all patients need to have documented antibodies to hepatitis c virus (hcv) and circulating hcv-rna as measured by reverse-transcription polymerase chain reaction (cobas amplicor hcv monitor™ test, roche diagnostics)
boolean
C0166049 (UMLS CUI [1])
C1868902 (UMLS CUI [2,1])
C0175630 (UMLS CUI [2,2])
C0599161 (UMLS CUI [3])
Insufficient knowledge German language | Impaired cognition | Questionnaires Comprehension
Item
insufficient knowledge of the german language or cognitive impairment (due to the indispensable application of questionnaires and the tap, test battery of attentional performance).
boolean
C4062254 (UMLS CUI [1,1])
C0017477 (UMLS CUI [1,2])
C0338656 (UMLS CUI [2])
C0034394 (UMLS CUI [3,1])
C0162340 (UMLS CUI [3,2])
Exclusion Criteria Additional
Item
further exclusion criteria:
boolean
C0680251 (UMLS CUI [1,1])
C1524062 (UMLS CUI [1,2])
Age
Item
age under 18 years or over 65 years
boolean
C0001779 (UMLS CUI [1])
HBV coinfection | HIV coinfection
Item
coinfections such as hepatitis b virus or human immunodeficiency virus
boolean
C2242656 (UMLS CUI [1])
C4062778 (UMLS CUI [2])
Disease Internal Severe | Malignant Neoplasms | Myocardial Ischemia | Autoimmune Diseases
Item
severe internal diseases (e.g., cancer, ischemic heart disease, autoimmune disease)
boolean
C0012634 (UMLS CUI [1,1])
C0205102 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
C0006826 (UMLS CUI [2])
C0151744 (UMLS CUI [3])
C0004364 (UMLS CUI [4])
Major Depressive Disorder | Psychotic Disorders | intravenous drug use | Alcohol abuse
Item
major depressive disorder (according to the diagnostic and statistical manual of mental disorders, fourth edition [dsm-iv] criteria), psychosis, active intravenous drug use or alcohol abuse.
boolean
C1269683 (UMLS CUI [1])
C0033975 (UMLS CUI [2])
C0699778 (UMLS CUI [3])
C0085762 (UMLS CUI [4])
Confounding variables Exclusion
Item
these additional exclusion criteria are important in order to avoid interfering or confounding effects by other variables that are not linked to the hepatitis c infection.
boolean
C0009673 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])