criteria Fulfill
Item
to fulfill criteria for study entry, the patient must:
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
Age
Item
be 18 years of age or older.
boolean
C0001779 (UMLS CUI [1])
HCV viral load Detectable
Item
have detectable hcv rna
boolean
C1868902 (UMLS CUI [1,1])
C3830527 (UMLS CUI [1,2])
Orthotopic liver transplant Patient need for | Liver Cirrhosis Due to Chronic Hepatitis C | Kidney Transplantation Patient need for | Kidney Failure, Chronic
Item
require orthotopic liver transplantation for chronic hepatitis c induced cirrhosis or require renal transplantation for end-stage kidney disease
boolean
C0400447 (UMLS CUI [1,1])
C0686904 (UMLS CUI [1,2])
C0023890 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0524910 (UMLS CUI [2,3])
C0022671 (UMLS CUI [3,1])
C0686904 (UMLS CUI [3,2])
C0022661 (UMLS CUI [4])
Transplantation of liver Model for end stage liver disease score | Transplantation of liver Probability High | Kidney Transplantation Probability High
Item
have a meld score greater than 18 (for liver transplant patients) or have an otherwise high probability of receiving a liver or kidney transplant within six months of enrollment based on assessment by the clinical transplant team at each hospital.
boolean
C0023911 (UMLS CUI [1,1])
C4048785 (UMLS CUI [1,2])
C0023911 (UMLS CUI [2,1])
C0033204 (UMLS CUI [2,2])
C0205250 (UMLS CUI [2,3])
C0022671 (UMLS CUI [3,1])
C0033204 (UMLS CUI [3,2])
C0205250 (UMLS CUI [3,3])
Collection of blood specimen for laboratory procedure Willing | Transplantation of liver Prior to | Kidney Transplantation Prior to
Item
be able/willing to travel to the collaborating center for blood sampling prior to liver or kidney transplantation, and at 2, 3, 4, 5, 6, 8, 12, 16, 24 weeks after transplantation and then bi-annually until the end of the study at 5 years
boolean
C0005834 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
C0023911 (UMLS CUI [2,1])
C0332152 (UMLS CUI [2,2])
C0022671 (UMLS CUI [3,1])
C0332152 (UMLS CUI [3,2])
Biopsy of liver Willing
Item
be willing to have study-related liver biopsies at 3 months, and then 1, 3 and 5 years after transplantation
boolean
C0193388 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
Informed Consent
Item
provide informed consent.
boolean
C0021430 (UMLS CUI [1])
criteria Fulfill
Item
to fulfill criteria for study entry, the patient must not:
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
HIV Seropositivity | Hepatitis B Virus Positive | Hepatitis B surface antigen positive
Item
be hiv or hepatitis b virus (hbsag) positive
boolean
C0019699 (UMLS CUI [1])
C0019169 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C0149709 (UMLS CUI [3])
Recipient Liver graft | Tissue Donor Hepatitis C Antibodies Positive | Tissue Donor Hepatitis B Viral core Positive
Item
receive a liver graft from an anti-hcv antibody positive or hbv core positive donor
boolean
C1709854 (UMLS CUI [1,1])
C1720613 (UMLS CUI [1,2])
C0040288 (UMLS CUI [2,1])
C0166049 (UMLS CUI [2,2])
C1514241 (UMLS CUI [2,3])
C0040288 (UMLS CUI [3,1])
C0019163 (UMLS CUI [3,2])
C1268457 (UMLS CUI [3,3])
C1514241 (UMLS CUI [3,4])
Liver diseases | Primary biliary cirrhosis | Hepatitis, Autoimmune | Hemochromatosis | Hepatolenticular Degeneration
Item
have other forms of liver disease including primary biliary cirrhosis, autoimmune hepatitis, hemochromatosis and wilson's disease
boolean
C0023895 (UMLS CUI [1])
C0008312 (UMLS CUI [2])
C0241910 (UMLS CUI [3])
C0018995 (UMLS CUI [4])
C0019202 (UMLS CUI [5])
Liver carcinoma Single lesion Size | Lesion Quantity Size
Item
have hepatocellular carcinoma if any single lesion is 5 cm. or more or if there are 3 or more lesions exceeding 3 cm.
boolean
C2239176 (UMLS CUI [1,1])
C0577304 (UMLS CUI [1,2])
C0456389 (UMLS CUI [1,3])
C0221198 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0456389 (UMLS CUI [2,3])
Immunomodulators | Adrenal Cortex Hormones | Collection of blood specimen for laboratory procedure Before Transplantation
Item
be on immunomodulatory medications such as corticosteroids within four weeks of collection of blood for pre-transplant baseline laboratory testing
boolean
C1527392 (UMLS CUI [1])
C0001617 (UMLS CUI [2])
C0005834 (UMLS CUI [3,1])
C0332152 (UMLS CUI [3,2])
C0040732 (UMLS CUI [3,3])
Immunodeficiency Hereditary Transplantation of liver Prior to | Immunodeficiency Hereditary Kidney Transplantation Prior to | Acquired immunodeficiency Transplantation of liver Prior to | Acquired immunodeficiency Kidney Transplantation Prior to
Item
have been diagnosed with any hereditary or acquired immunodeficiency state prior to liver or kidney transplantation
boolean
C0021051 (UMLS CUI [1,1])
C0439660 (UMLS CUI [1,2])
C0023911 (UMLS CUI [1,3])
C0332152 (UMLS CUI [1,4])
C0021051 (UMLS CUI [2,1])
C0439660 (UMLS CUI [2,2])
C0022671 (UMLS CUI [2,3])
C0332152 (UMLS CUI [2,4])
C0596032 (UMLS CUI [3,1])
C0023911 (UMLS CUI [3,2])
C0332152 (UMLS CUI [3,3])
C0596032 (UMLS CUI [4,1])
C0022671 (UMLS CUI [4,2])
C0332152 (UMLS CUI [4,3])