Hypertensive disease | Age
Item
hypertensive patients will be 18 to 75-year old.
boolean
C0020538 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Informed Consent | End organ damage Evaluation | Echocardiography | Carotid artery ultrasound | Urine dipstick test
Item
eligible patients will be asked for written informed consent and thereafter referred to the identified hypertension specialist centre located in their areas, for end-organ damage evaluation by echocardiography, carotid ultrasound and urine dip-stick.
boolean
C0021430 (UMLS CUI [1])
C0743496 (UMLS CUI [2,1])
C1261322 (UMLS CUI [2,2])
C0013516 (UMLS CUI [3])
C0948945 (UMLS CUI [4])
C0430370 (UMLS CUI [5])
Hypertensive disease stage | Hypertension untreated | Poor hypertension control | Study Subject Participation Status | Pharmaceutical Preparation Single High dose | Pharmaceutical Preparations multiple
Item
eligible patients are required to have stage ic or ii essential hypertension, and to be previously untreated or poorly controlled. they will be selected by gps participating into the study. similar to untreated patients, those with poor control of blood pressure under multiple-drug therapy will start treatment with one single drug, which will be titrated to the highest dose before adding subsequent medications, based on the gp's judgement.
boolean
C0020538 (UMLS CUI [1,1])
C0699749 (UMLS CUI [1,2])
C0745134 (UMLS CUI [2])
C0421190 (UMLS CUI [3])
C2348568 (UMLS CUI [4])
C0013227 (UMLS CUI [5,1])
C0205171 (UMLS CUI [5,2])
C0444956 (UMLS CUI [5,3])
C0013227 (UMLS CUI [6,1])
C0439064 (UMLS CUI [6,2])
Hypertensive disease | Hematologic Tests | Urinalysis | Blood Cell Count | Creatinine measurement, serum | Sodium measurement | Potassium measurement | Uric acid measurement | Serum total cholesterol measurement | Triglycerides measurement | Serum HDL cholesterol measurement | Glucose measurement | Electrocardiography
Item
hypertension will be defined according to 2003 esh/esc guidelines (1). blood and urine tests will be performed, according to guidelines for hypertension management for general practitioners (gp) of the regione campania (see burc number 11, 18/02/2002). this screening includes cell blood counts (cbcs), serum creatinine, sodium, potassium, uric acid, total cholesterol, triglycerides, hdl-cholesterol, glucose, urine analysis and ekg. ldl will be calculated starting from the total cholesterol, triglyceride and hdl-cholesterol.
boolean
C0020538 (UMLS CUI [1])
C0018941 (UMLS CUI [2])
C0042014 (UMLS CUI [3])
C0005771 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
C0337443 (UMLS CUI [6])
C0202194 (UMLS CUI [7])
C0202239 (UMLS CUI [8])
C1445957 (UMLS CUI [9])
C0202236 (UMLS CUI [10])
C0428472 (UMLS CUI [11])
C0337438 (UMLS CUI [12])
C1623258 (UMLS CUI [13])
Childbearing Potential Contraceptive methods Missing | Pregnancy | Breast Feeding | Medical contraindication Antihypertensive Agents many
Item
omen in fertile age not using recognized contraceptive methods, or pregnant or nursing will be excluded from the protocol, since the use of many antihypertensive drugs is contraindicated in pregnancy and lactation.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C1705492 (UMLS CUI [1,3])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C1301624 (UMLS CUI [4,1])
C0003364 (UMLS CUI [4,2])
C0439064 (UMLS CUI [4,3])
Heart Event New York Heart Association Classification | Event Cerebrovascular New York Heart Association Classification
Item
patients will be excluded when presenting with documented coronary or cerebrovascular events in the previous 6 months, nyha class higher than 1
boolean
C0018787 (UMLS CUI [1,1])
C0441471 (UMLS CUI [1,2])
C1275491 (UMLS CUI [1,3])
C0441471 (UMLS CUI [2,1])
C1880018 (UMLS CUI [2,2])
C1275491 (UMLS CUI [2,3])
Congestive heart failure
Item
history of congestive heart failure
boolean
C0018802 (UMLS CUI [1])
Secondary hypertension
Item
secondary hypertension
boolean
C0155616 (UMLS CUI [1])
Malignant Neoplasms
Item
cancer disease
boolean
C0006826 (UMLS CUI [1])
Kidney Diseases | Creatinine measurement, serum
Item
renal disease (serum creatinine >2 mg/dl)
boolean
C0022658 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Liver Cirrhosis | Liver Dysfunction Severe | Health Problem Interferes with Clinical Study Follow-up
Item
liver cirrhosis or severe dysfunction, or any other health problem that may interfere with the projected 2 year follow-up.
boolean
C0023890 (UMLS CUI [1])
C0086565 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0018684 (UMLS CUI [3,1])
C0033213 (UMLS CUI [3,2])
C0521102 (UMLS CUI [3,3])
C3274571 (UMLS CUI [3,4])
Data Storage Database | Echocardiography Evaluation | Left ventricular ejection fraction
Item
data will be stored in an electronic database located in the coordinating centre, to which gps may have access for uploading data on a daily base, using personal, encrypted, login and password. these data will be stored in the central database. after local echocardiographic evaluation, patients showing left ventricular ejection fraction < 45% will be excluded from the study.
boolean
C0242578 (UMLS CUI [1,1])
C0242356 (UMLS CUI [1,2])
C0013516 (UMLS CUI [2,1])
C1261322 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3])