age, advanced hematological malignancies, relapsed after or are refractory to standard therapy
Item
adult patients (≥18 years old) with advanced hematological malignancies who have relapsed after or are refractory to standard therapy, or for which no standard therapy exists; or, are considered inappropriate candidates for standard therapy
boolean
C0001779 (UMLS CUI [1])
C0376545 (UMLS CUI [2,1])
C0679246 (UMLS CUI [2,2])
C0277556 (UMLS CUI [3])
C0205269 (UMLS CUI [4])
who performance status
Item
world health organization (who) performance status ≤ 2
boolean
C1298650 (UMLS CUI [1])
laboratory
Item
patients must meet protocol-specified hematologic and non-hematologic laboratory values
boolean
C0587081 (UMLS CUI [1])
liver function, renal function
Item
patients must have adequate liver and renal function
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
brain metastases, leukemic infiltration of the cerebrospinal fluid
Item
concurrent brain metastases or leukemic infiltration of the cerebrospinal fluid
boolean
C0220650 (UMLS CUI [1])
C0162679 (UMLS CUI [2,1])
C0007806 (UMLS CUI [2,2])
peripheral neuropathy
Item
peripheral neuropathy ≥ ctcae grade 2
boolean
C0031117 (UMLS CUI [1])
unresolved diarrhea
Item
unresolved diarrhea ≥ ctcae grade 2
boolean
C0267664 (UMLS CUI [1])
Comorbidity; Limited (extensiveness); Protocol Compliance | Decreased cardiac function | Heart Diseases | Abnormal digestive tract function; drug absorption
Item
concurrent severe and/or uncontrolled medical conditions which may compromise participation in the study, including impaired heart function or clinically significant heart disease, and impaired gastrointestinal function or disease that may significantly alter aborption of lbh589
boolean
C0009488 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0232166 (UMLS CUI [2])
C0018799 (UMLS CUI [3])
C0232459 (UMLS CUI [4,1])
C0678745 (UMLS CUI [4,2])
pregnancy, breast feeding
Item
female patients who are pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
contraceptive methods
Item
patients not willing to use an effective method of birth control
boolean
C0700589 (UMLS CUI [1])
Pharmaceutical Preparations; Drug Interactions; LBH589
Item
patients taking medications specified by the protocol as prohibited for administration in combination with lbh589
boolean
C0013227 (UMLS CUI [1,1])
C0687133 (UMLS CUI [1,2])
C1566164 (UMLS CUI [1,3])
Comorbidity; Malignant Neoplasms; Treatment required for
Item
patients with another primary malignancy that currently requires active intervention or is currently clinically significant
boolean
C0009488 (UMLS CUI [1,1])
C0006826 (UMLS CUI [1,2])
C0332121 (UMLS CUI [1,3])
ID.13
Item
other protocol-defined inclusion/exclusion criteria may apply
boolean