histologic proof of breast cancer (invasive ductal or lobular carcinoma)
Item
histologic proof of breast cancer (invasive ductal or lobular carcinoma - not breast sarcoma or lymphoma)
boolean
C0678222 (UMLS CUI [1,1])
C0679557 (UMLS CUI [1,2])
C1334276 (UMLS CUI [2])
Locally advanced breast cancer; TNM Staging System | Inflammatory Breast Carcinoma
Item
patients having a clinical diagnosis of locally advanced breast cancer (t3 or t4, or n2 according to tnm classification) including inflammatory breast cancer.
boolean
C3495949 (UMLS CUI [1,1])
C1515169 (UMLS CUI [1,2])
C0278601 (UMLS CUI [2])
neoadjuvant chemotherapy
Item
patients must be able to undergo neoadjuvant chemotherapy.
boolean
C0392920 (UMLS CUI [1,1])
C0600558 (UMLS CUI [1,2])
ecog
Item
eastern cooperative oncology group (ecog) performance status of 0, 1 or 2 sufficient to undergo chemotherapy
boolean
C1520224 (UMLS CUI [1])
History of neoplastic disease | Nonmelanoma skin cancer (in some patients) | Carcinoma in situ of uterine cervix | Individual Cancer History; Disease-Free Survival
Item
previously treated cancer other than nonmelanotic skin cancer or carcinoma in situ of the cervix, unless disease-free for 5 years or greater.
boolean
C2735088 (UMLS CUI [1])
C3281209 (UMLS CUI [2])
C0851140 (UMLS CUI [3])
C1512706 (UMLS CUI [4,1])
C0242793 (UMLS CUI [4,2])
metastatic disease (found on chest x-ray, liver ultrasound or bone scan)
Item
evidence of metastatic disease (found on chest x-ray, liver ultrasound or bone scan).
boolean
C2939420 (UMLS CUI [1])
C0039985 (UMLS CUI [2])
C0412534 (UMLS CUI [3])
C0203668 (UMLS CUI [4])
previous chemotherapy or hormonal therapy for breast cancer
Item
previous chemotherapy or hormonal therapy for breast cancer.
boolean
C1514457 (UMLS CUI [1,1])
C0678222 (UMLS CUI [1,2])
C1514460 (UMLS CUI [2,1])
C0678222 (UMLS CUI [2,2])
Communicable Diseases; Active | Comorbidity | Chemotherapy coping
Item
active infection or other significant illnesses which could hamper their ability to tolerate chemotherapy
boolean
C0009450 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2])
C0742248 (UMLS CUI [3])
Comorbidity | Medically fit for surgery | Diabetic - poor control | Heart Diseases | Severe chronic obstructive pulmonary disease
Item
significant concurrent medical problems (e.g. uncontrolled diabetes, active cardiac disease, severe chronic obstructive pulmonary disease) making the patient unfit for surgery.
boolean
C0009488 (UMLS CUI [1])
C4075860 (UMLS CUI [2])
C0421258 (UMLS CUI [3])
C0018799 (UMLS CUI [4])
C0730607 (UMLS CUI [5])
Informed Consent | Comorbidity; Limited (extensiveness); Protocol Compliance | Dementia | Severe cognitive impairment
Item
any condition that could interfere with their ability to provide informed consent such as dementia or severe cognitive impairment.
boolean
C0021430 (UMLS CUI [1])
C0009488 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C0497327 (UMLS CUI [3])
C3554639 (UMLS CUI [4])
pregnancy, breast feeding
Item
pregnant or lactating females (e.g. positive serum b-hcg pregnancy test).
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
unable to lie supine for imaging with pet
Item
unable to lie supine for imaging with pet.
boolean
C0032743 (UMLS CUI [1,1])
C0560840 (UMLS CUI [1,2])
White Blood Cell Count procedure | Hemoglobin measurement | Platelet Count measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Gamma glutamyl transferase measurement | Alkaline phosphatase measurement | Serum total bilirubin measurement | Creatinine measurement, serum (procedure)
Item
inadequate hematologic, renal and liver function as measured by cbc (wbc < 4.0 x 109, hb < 100 g/l, plt count < 100 x 109), and abnormal hepatic transaminases (ast, alt, ggt, alkaline phosphatase > 2x normal), elevated total bilirubin, and elevated serum creatinine (cr > 110 micromol/l).
boolean
C0023508 (UMLS CUI [1])
C0518015 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C0202035 (UMLS CUI [6])
C0201850 (UMLS CUI [7])
C1278039 (UMLS CUI [8])
C0201976 (UMLS CUI [9])
any contraindication to undergoing mri or pet
Item
any contraindication to undergoing mri or pet.
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0032743 (UMLS CUI [2,2])