hepatitis c
Item
hcv-infected
boolean
C1112419 (UMLS CUI [1])
hiv
Item
hiv-infected
boolean
C0019682 (UMLS CUI [1])
liver biopsy, chronic hepatitis
Item
liver biopsy consistent with chronic hepatitis within 1 year of study entry.
boolean
C0193388 (UMLS CUI [1])
C0019189 (UMLS CUI [2])
antiretroviral therapy
Item
art-naive or no art for at least 3 months prior to study entry
boolean
C1963724 (UMLS CUI [1])
hb
Item
hemoglobin less than 9 g/dl.
boolean
C0518015 (UMLS CUI [1])
Hepatitis B | Antibody to hepatitis B core antigen | alpha 1-Antitrypsin Deficiency | Hepatolenticular Degeneration | Hemochromatosis | Autoimmune Diseases | Liver diseases
Item
hepatitis b virus infected or antibody to hepatitis b core antigen, alpha-1 antitrypsin deficiency, wilson's disease, hemochromatosis, autoimmune disorder, or other concurrent liver disease
boolean
C0019163 (UMLS CUI [1])
C0312631 (UMLS CUI [2])
C0221757 (UMLS CUI [3])
C0019202 (UMLS CUI [4])
C0018995 (UMLS CUI [5])
C0004364 (UMLS CUI [6])
C0023895 (UMLS CUI [7])
Decompensated liver disease | Hepatic Encephalopathy | Ascites | Bleeding varices | Prothrombin time assay | International Normalized Ratio | Platelet Count measurement | Liver Cirrhosis
Item
decompensated liver disease evidenced by active or history of encephalopathy, ascites, or variceal bleeding; prothrombin time (pt) greater than 3 seconds above normal or international normalized ratio (inr) greater than 1.3 sec; platelet count less than 90,000 k/ul. participants with cirrhosis will not be excluded.
boolean
C4075847 (UMLS CUI [1])
C0019151 (UMLS CUI [2])
C0003962 (UMLS CUI [3])
C0333106 (UMLS CUI [4])
C0033707 (UMLS CUI [5])
C0525032 (UMLS CUI [6])
C0032181 (UMLS CUI [7])
C0023890 (UMLS CUI [8])
Thyroid Diseases; Active | Thyroid hormone replacement therapy; Serum TSH level normal
Item
active thyroid disease. participants on thyroid replacement therapy with normal thyroid-stimulating hormone are not excluded.
boolean
C0040128 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
C2242640 (UMLS CUI [2,1])
C0580433 (UMLS CUI [2,2])
creatinine clearance, chronic kidney insufficiency
Item
chronic kidney insufficiency, defined as creatinine clearance of greater than approximately 50 ml/min
boolean
C0373595 (UMLS CUI [1])
C0403447 (UMLS CUI [2])
Severe (severity modifier); Comorbidity | Limited (extensiveness); Protocol Compliance
Item
life-threatening disease processes other than hiv or hcv that could interfere with participation in the study
boolean
C0205082 (UMLS CUI [1,1])
C0009488 (UMLS CUI [1,2])
C0439801 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
Comorbidity | Limited (extensiveness); Protocol Compliance | Mental disorders | Substance Use Disorders
Item
any condition that, in the opinion of the investigator, may interfere with completion of the study regimen. this includes severe psychiatric disorders, or active alcohol or recreational drug abuse
boolean
C0009488 (UMLS CUI [1])
C0439801 (UMLS CUI [2,1])
C0525058 (UMLS CUI [2,2])
C0004936 (UMLS CUI [3])
C0038586 (UMLS CUI [4])
steroid therapy
Item
use of systemic corticosteroids or immunomodulatory drugs within 1 month prior to study entry
boolean
C0149783 (UMLS CUI [1])
C1527392 (UMLS CUI [2])
interferon treatment
Item
current or prior successful interferon treatment
boolean
C0279030 (UMLS CUI [1])
pregnancy, breastfeeding
Item
pregnancy or breastfeeding.
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])