Outpatients | Age
Item
male and female outpatients between the ages of 18 and 70.
boolean
C0029921 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
DEPRESSIVE DISORDER MAJOR WITHOUT PSYCHOTIC FEATURE Unipolar
Item
patients with a principal diagnostic and statistical manual fourth edition (dsm-iv) diagnosis of major depressive disorder, unipolar, nonpsychotic type
boolean
C0743081 (UMLS CUI [1,1])
C0443340 (UMLS CUI [1,2])
Hamilton rating scale for depression
Item
patients with a total of 14 or higher on the 17-item hamilton depression scale at baseline
boolean
C0451203 (UMLS CUI [1])
Selective Serotonin Reuptake Inhibitors Dose Adequate
Item
patients who have had treatment with an ssri at an adequate dose (see table for a minimum of 6 weeks (i.e. 6 wks at the dose defined as adequate in table 2)
boolean
C0360105 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205411 (UMLS CUI [1,3])
Contraceptive methods Agree
Item
patients who agree to use acceptable method of birth control throughout the study
boolean
C0700589 (UMLS CUI [1,1])
C3641827 (UMLS CUI [1,2])
Delirium | Dementia | Amnestic Disorder | Cognition Disorders | Bipolar Disorder | Cyclothymic Disorder | Schizophrenia | Delusional disorder | Paranoia | Psychotic Disorders | Borderline Personality Disorder Severe | Anorexia Nervosa | Bulimia
Item
patients with any of the following dsm-iv diagnoses: delirium, dementia, amnestic, or other cognitive disorders. bipolar disorder or cyclothymia, schizophrenia, delusional (paranoid) disorders and psychotic disorders not elsewhere classified, severe borderline personality disorder, anorexia nervosa, or bulimia.
boolean
C0011206 (UMLS CUI [1])
C0497327 (UMLS CUI [2])
C0002625 (UMLS CUI [3])
C0009241 (UMLS CUI [4])
C0005586 (UMLS CUI [5])
C0010598 (UMLS CUI [6])
C0036341 (UMLS CUI [7])
C0011251 (UMLS CUI [8])
C1456784 (UMLS CUI [9])
C0033975 (UMLS CUI [10])
C0006012 (UMLS CUI [11,1])
C0205082 (UMLS CUI [11,2])
C0003125 (UMLS CUI [12])
C0006370 (UMLS CUI [13])
Substance Use Disorders | Substance Dependence
Item
patients who, within the past 6 months, met dsm-iv criteria for abuse of or dependence on any drug, including alcohol.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
patients who are pregnant or nursing women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
At risk for suicide | Suicide Plan | Hamilton rating scale for depression
Item
patients who would pose a serious risk for suicide during the course of the study, as evidenced by one of the following: (a) report of having a specific plan for killing themselves, (b) a score of 3 or higher on the hamilton depression rating scale item
boolean
C0563664 (UMLS CUI [1])
C0038661 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
C0451203 (UMLS CUI [3])
Suicide attempt Required emergency room/doctor visit | Suicide attempt Life Threatening Possible
Item
#3 as rated by the treating clinician at week 0, or (c) a suicide attempt within the last 6 months which required medical attention, such as an emergency room visit or which is considered by the treating physician to have been possibly life threatening
boolean
C0038663 (UMLS CUI [1,1])
C3846016 (UMLS CUI [1,2])
C0038663 (UMLS CUI [2,1])
C2826244 (UMLS CUI [2,2])
C0332149 (UMLS CUI [2,3])
Medical condition Unstable | Hyperthyroidism untreated | Hyperthyroidism Uncontrolled | Hypothyroidism untreated | Hypothyroidism Uncontrolled | hypertension untreated | Uncontrolled hypertension | Blood Pressure | Cardiovascular Disease untreated | Cardiovascular Disease Uncontrolled | Diabetes Mellitus untreated | Diabetic - poor control | HIV Infection untreated | HIV Infection Uncontrolled
Item
patients with unstable medical conditions such as untreated or uncontrolled hyperthyroidism, hypothyroidism, hypertension (defined as blood pressure>150/90), cardiovascular disease, diabetes, hiv (by report of patient).
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0020550 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C0020550 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C2749407 (UMLS CUI [4])
C0020676 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
C0745134 (UMLS CUI [6])
C1868885 (UMLS CUI [7])
C0005823 (UMLS CUI [8])
C0007222 (UMLS CUI [9,1])
C0332155 (UMLS CUI [9,2])
C0007222 (UMLS CUI [10,1])
C0205318 (UMLS CUI [10,2])
C0011849 (UMLS CUI [11,1])
C0332155 (UMLS CUI [11,2])
C0421258 (UMLS CUI [12])
C0019693 (UMLS CUI [13,1])
C0332155 (UMLS CUI [13,2])
C0019693 (UMLS CUI [14,1])
C0205318 (UMLS CUI [14,2])
Seizures
Item
patients with a history of seizures.
boolean
C0036572 (UMLS CUI [1])