Major depressive episode Associated with Major Depressive Disorder
Item
major depressive episode (mde) associated with major depressive disorder (dsm-iv-tr criteria)
boolean
C0024517 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C1269683 (UMLS CUI [1,3])
Major depressive episode Duration
Item
duration of current episode is at least 12 weeks duration and less than 2 years
boolean
C0024517 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
Fatigue Symptoms | Pleasure Decreased Symptoms | Loss of interest Symptoms
Item
symptoms of decreased energy, pleasure, and interest
boolean
C0015672 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0679105 (UMLS CUI [2,1])
C0205216 (UMLS CUI [2,2])
C1457887 (UMLS CUI [2,3])
C0424091 (UMLS CUI [3,1])
C1457887 (UMLS CUI [3,2])
Gender Contraceptive methods
Item
female subjects who agree to use acceptable methods of birth control throughout the study
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Panic Disorder | Generalized anxiety Symptoms Interfere with Protocol Compliance | Panic Attacks Interfere with Protocol Compliance
Item
current diagnosis of panic disorder, or symptoms of generalized anxiety or panic attacks that could interfere with their ability to complete the trial
boolean
C0030319 (UMLS CUI [1])
C0262376 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C0525058 (UMLS CUI [2,4])
C0086769 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
Major depressive episode Symptoms | Diagnosis Alternative Required
Item
symptoms of mde better accounted for by another diagnosis
boolean
C0024517 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0011900 (UMLS CUI [2,1])
C1523987 (UMLS CUI [2,2])
C1514873 (UMLS CUI [2,3])
Panic Disorder | Panic Attacks | anxiety generalized | Borderline Personality Disorder | Antisocial Personality Disorder | Dementia | Anorexia Nervosa | Bulimia | Bipolar Disorder | Schizophrenia | Psychotic Disorders
Item
diagnosis of panic disorder / attacks, generalised anxiety, borderline or antisocial personality disorder, dementia, anorexia nervosa / bulimia (within 6 months of screening), bipolar disorder, schizophrenia or any other psychotic disorder(s).
boolean
C0030319 (UMLS CUI [1])
C0086769 (UMLS CUI [2])
C0262376 (UMLS CUI [3])
C0006012 (UMLS CUI [4])
C0003431 (UMLS CUI [5])
C0497327 (UMLS CUI [6])
C0003125 (UMLS CUI [7])
C0006370 (UMLS CUI [8])
C0005586 (UMLS CUI [9])
C0036341 (UMLS CUI [10])
C0033975 (UMLS CUI [11])
Psychotherapy Started
Item
started psychotherapy within 3 months prior to the screening
boolean
C0033968 (UMLS CUI [1,1])
C1272689 (UMLS CUI [1,2])
Electroconvulsive Therapy | Transcranial magnetic stimulation
Item
received electroconvulsive therapy or transcranial magnetic stimulation within 6 months prior to screening
boolean
C0013806 (UMLS CUI [1])
C0436548 (UMLS CUI [2])
Psychotropic Drugs
Item
received psychoactive drugs within 4 weeks of randomization
boolean
C0033978 (UMLS CUI [1])
Urine drug screen positive | Blood alcohol test positive
Item
positive urine drug screen or positive blood alcohol
boolean
C0743300 (UMLS CUI [1])
C0948726 (UMLS CUI [2])
At risk for suicide | Suicide attempt | Suicide attempt Family history
Item
suicidal risk or has had any previous suicide attempt, a family history of suicide attempt
boolean
C0563664 (UMLS CUI [1])
C0038663 (UMLS CUI [2])
C0038663 (UMLS CUI [3,1])
C0241889 (UMLS CUI [3,2])
Pregnancy test positive
Item
positive pregnancy test
boolean
C0240802 (UMLS CUI [1])
Epilepsy | Myocardial Infarction | Medical condition Unstable
Item
history of seizure disorder, myocardial infarction (< 1yr), or unstable medical condition
boolean
C0014544 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C3843040 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
Pharmacotherapy failed | Antidepressive Agents Different failed
Item
failed to respond to an adequate course of pharmacotherapy of at least 2 different antidepressants
boolean
C0013216 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])
C0003289 (UMLS CUI [2,1])
C1705242 (UMLS CUI [2,2])
C0231175 (UMLS CUI [2,3])