Gender
Item
males and females
boolean
C0079399 (UMLS CUI [1])
Age
Item
age: 18-50
boolean
C0001779 (UMLS CUI [1])
Major Depressive Disorder Recurrent | Major depressive episode | Major depressive episode Previous Quantity
Item
recurrent major depressive disorder; current major depressive episode with at least one prior episode
boolean
C1269683 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C0024517 (UMLS CUI [2])
C0024517 (UMLS CUI [3,1])
C0205156 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
Hamilton rating scale for depression
Item
ham-d >16
boolean
C0451203 (UMLS CUI [1])
Informed Consent
Item
able to give written informed consent
boolean
C0021430 (UMLS CUI [1])
Childbearing Potential Contraceptive methods reliable
Item
agree to use a reliable means of birth control during the study, as determined by the investigator (females of child-bearing potential only)
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C3858758 (UMLS CUI [1,3])
Craniocerebral Trauma | Unconscious State
Item
history of head injury or loss of consciousness for longer than 30 minutes
boolean
C0018674 (UMLS CUI [1])
C0041657 (UMLS CUI [2])
Anxiety Disorders Primary | Bipolar I disorder | Bipolar II disorder | Psychotic Disorders
Item
presence of primary anxiety disorder, bipolar i or ii disorder, or psychotic disorders
boolean
C0003469 (UMLS CUI [1,1])
C0205225 (UMLS CUI [1,2])
C0853193 (UMLS CUI [2])
C0236788 (UMLS CUI [3])
C0033975 (UMLS CUI [4])
Anorexia Nervosa | Bulimia Nervosa
Item
presence of anorexia nervosa or bulimia nervosa
boolean
C0003125 (UMLS CUI [1])
C2267227 (UMLS CUI [2])
Epilepsy | Seizures
Item
presence or history of epilepsy or other seizure disorders
boolean
C0014544 (UMLS CUI [1])
C0036572 (UMLS CUI [2])
Axis II diagnosis
Item
presence of significant axis ii disorder based on investigator judgment
boolean
C0270288 (UMLS CUI [1])
Medical condition Unstable
Item
presence of significant unstable medical condition
boolean
C3843040 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
Attention deficit hyperactivity disorder | Learning Disability
Item
presence or past history of adhd or significant learning disability
boolean
C1263846 (UMLS CUI [1])
C0751265 (UMLS CUI [2])
Unilateral electroconvulsive therapy | Bilateral electroconvulsive therapy
Item
ects (unilateral) within the past 12 months or bilateral ect (ever)
boolean
C0562344 (UMLS CUI [1])
C0562343 (UMLS CUI [2])
Major depressive episode | Antidepressive Agents Quantity failed
Item
more than 2 failed adequate antidepressant treatments in the current episode
boolean
C0024517 (UMLS CUI [1])
C0003289 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0231175 (UMLS CUI [2,3])
Pregnancy | Breast Feeding
Item
pregnant or breast-feeding females
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Investigational New Drugs
Item
have received treatment within the last 30 days with an investigational drug
boolean
C0013230 (UMLS CUI [1])
Bupropion Extended Release non-responsive | Escitalopram non-responsive
Item
prior non-response to either bupropion-xl or escitalopram
boolean
C0085208 (UMLS CUI [1,1])
C1707968 (UMLS CUI [1,2])
C3844724 (UMLS CUI [1,3])
C1099456 (UMLS CUI [2,1])
C3844724 (UMLS CUI [2,2])
Zyban | Bupropion Hydrochloride
Item
current treatment with zyban (bupropion hydrochloride)
boolean
C0751626 (UMLS CUI [1])
C0700563 (UMLS CUI [2])
Antidepressive Agents | Fluoxetine
Item
antidepressant treatment within the last week (within the last 3 weeks fluoxetine)
boolean
C0003289 (UMLS CUI [1])
C0016365 (UMLS CUI [2])