ID.1
Item
patients:
boolean
dopa-responsive parkinson
Item
patients with established, dopa-responsive pd, hoehn and yahr stage i-iii, age 21 and older will be included.
boolean
C4012421 (UMLS CUI [1])
C3639483 (UMLS CUI [2])
C0001779 (UMLS CUI [3])
ID.3
Item
patients will be recruited from the ninds hmcs and etb clinical programs and from the community.
boolean
ID.4
Item
healthy controls:
boolean
age
Item
healthy controls 21 and older will be recruited through the nih clinical research volunteer program and from the community.
boolean
C0001779 (UMLS CUI [1])
ID.6
Item
exclusionary criteria will be: any significant medical or psychiatric illness (other than pd), pregnancy, history of epilepsy, concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs that could lower the seizure threshold or significantly affect cortical excitability.
boolean
C0221423 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C2347852 (UMLS CUI [4,1])
C0003290 (UMLS CUI [4,2])
C2347852 (UMLS CUI [5,1])
C0040615 (UMLS CUI [5,2])
foreign bodies in the head
Item
persons with surgically or traumatically implanted foreign bodies in the head (other than dental appliances of fillings) that may pose a physical hazard during magnetic stimulation will also be excluded.
boolean
C0016542 (UMLS CUI [1,1])
C0018670 (UMLS CUI [1,2])
ID.8
Item
patients:
boolean
persistent tremor
Item
patients with persistent "resting" tremor that precludes testing at rest may be excluded as well as any patient to whom the screening physician makes a judgment that withdrawal of medications poses a significant risk due to immobility or risk of falling.
boolean
C0234370 (UMLS CUI [1])
long-acting dopamine agonists
Item
patients on long-acting dopamine agonists will also be excluded.
boolean
C0178601 (UMLS CUI [1])
hoehn and yahr stage iv
Item
patients in hoehn and yahr stage iv will also be excluded, since they are least likely to tolerate medication withdrawal and are also unlikely to be able to maintain muscle relaxation for tms testing.
boolean
C3639483 (UMLS CUI [1])
no significant medical or psychiatric illness
Item
no significant medical or psychiatric illness (other than pd), pregnancy, history of epilepsy, concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs that could lower the seizure threshold or significantly affect cortical excitability.
boolean
C0221423 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C2347852 (UMLS CUI [4,1])
C0003290 (UMLS CUI [4,2])
C2347852 (UMLS CUI [5,1])
C0040615 (UMLS CUI [5,2])
foreign bodies in the head
Item
must not have surgically or traumatically implanted foreign bodies in the head (other than dental appliances or fillings) that may pose a physical hazard during magnetic stimulation.
boolean
C0016542 (UMLS CUI [1,1])
C0018670 (UMLS CUI [1,2])
ID.14
Item
healthy controls:
boolean
age
Item
ages 21 and older will be recruited through the nih clinical research volunteer program (crvp) and from the community.
boolean
C0001779 (UMLS CUI [1])
ID.16
Item
all individuals will be processed through the crvp before participating. recruitment will be focused on optimizing age, sex, educational, and racial matching with patient group. patients' spouses will be invited to participate.
boolean
C0679646 (UMLS CUI [1])
no significant medical or psychiatric illness
Item
no significant medical or psychiatric illness (other than pd), pregnancy, history of epilepsy, concurrent use of tricyclic antidepressants, neuroleptic agents, or any other licit or illicit drugs that could lower the seizure threshold or significantly affect cortical excitability.
boolean
C0221423 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0014544 (UMLS CUI [3])
C2347852 (UMLS CUI [4,1])
C0003290 (UMLS CUI [4,2])
C2347852 (UMLS CUI [5,1])
C0040615 (UMLS CUI [5,2])
foreign bodies in the head
Item
must not have surgically or traumatically implanted foreign bodies in the head (other than dental appliances or fillings) that may pose a physical hazard during magnetic stimulation.
boolean
C0016542 (UMLS CUI [1,1])
C0018670 (UMLS CUI [1,2])