Treatment
Item
treatment naïve
boolean
C0087111 (UMLS CUI [1])
Age
Item
over 18 years old
boolean
C0001779 (UMLS CUI [1])
Anti-HCV
Item
anti-hcv (abbott hcv eia 2.0, abbott diagnostic, chicago, il) positive > 6 months
boolean
C0201487 (UMLS CUI [1])
HCV-RNA
Item
detectable serum quantitative hcv-rna (cobas amplicor hcv monitor v2.0, roche molecular systems, pleasanton, ca) with dynamic range 600~< 500,000 iu/ml
boolean
C0369335 (UMLS CUI [1])
Alanine aminotransferase
Item
serum alanine aminotransferase levels above the upper limit of normal with 6 months of enrollment
boolean
C0201836 (UMLS CUI [1])
Liver biopsy
Item
a liver biopsy consistent with the diagnosis of chronic hepatitis c
boolean
Hemoglobin
Item
anemia (hemoglobin < 13 gram per deciliter for men and < 12 gram per deciliter for women)
boolean
C0019046 (UMLS CUI [1])
Neutrophil count
Item
neutropenia (neutrophil count < 1,500 per cubic milliliter)
boolean
C0200633 (UMLS CUI [1])
Platelet
Item
thrombocytopenia (platelet < 90,000 per cubic milliliter)
boolean
C0005821 (UMLS CUI [1])
Coinfection
Item
co-infection with hepatitis b virus (hbv) or human immunodeficiency virus (hiv)
boolean
C0275524 (UMLS CUI [1])
Chronic alcohol abuse
Item
chronic alcohol abuse (daily consumption > 20 gram per day)
boolean
C0001973 (UMLS CUI [1])
Child-Pugh Class
Item
decompensated liver disease (child-pugh class b or c)
boolean
C2347612 (UMLS CUI [1])
Creatinine
Item
serum creatinine level more than 1.5 times the upper limit of normal
boolean
C0201976 (UMLS CUI [1])
Autoimmune liver disease
Item
autoimmune liver disease
boolean
C0400936 (UMLS CUI [1])
Neoplastic disease
Item
neoplastic disease
boolean
C1882062 (UMLS CUI [1])
Organ transplantation
Item
an organ transplant
boolean
C0029216 (UMLS CUI [1])
Immunosuppressive therapy
Item
immunosuppressive therapy
boolean
C0021079 (UMLS CUI [1])
Comorbidity
Item
poorly controlled autoimmune diseases, pulmonary diseases, cardiac diseases, psychiatric diseases, neurological diseases, diabetes mellitus
boolean
C0009488 (UMLS CUI [1])
Substance Use Disorder
Item
evidence of drug abuse
boolean
C0038586 (UMLS CUI [1])
Contraception
Item
unwilling to have contraception
boolean
C0700589 (UMLS CUI [1])
Blood sampling
Item
unwilling to receive serial blood sampling during the study
boolean
C0005834 (UMLS CUI [1])