Adenocarcinoma of colon | Adenocarcinoma of rectum | Neoplasm Metastasis Evidence of | Site of primary lesion Large Intestine Endoscopy | Site of primary lesion Large Intestine Diagnostic radiologic examination | Site of primary lesion Large Intestine Operative Surgical Procedures
Item
histologic proof of adenocarcinoma of the colon or rectum with evidence of metastatic disease. the site of the primary lesion must be or have been confirmed endoscopically, radiologically, or surgically to be or have been in the large bowel
boolean
C0338106 (UMLS CUI [1])
C0149978 (UMLS CUI [2])
C0027627 (UMLS CUI [3,1])
C0332120 (UMLS CUI [3,2])
C0449695 (UMLS CUI [4,1])
C0021851 (UMLS CUI [4,2])
C0014245 (UMLS CUI [4,3])
C0449695 (UMLS CUI [5,1])
C0021851 (UMLS CUI [5,2])
C0043299 (UMLS CUI [5,3])
C0449695 (UMLS CUI [6,1])
C0021851 (UMLS CUI [6,2])
C0543467 (UMLS CUI [6,3])
Chemotherapy Regimen Quantity Neoplasm Metastasis | fluorouracil/L-leucovorin | Xeloda | oxaliplatin | Avastin
Item
patients must have received one (and only one) prior chemotherapy regimen for metastatic disease using 5-fu/lv or xeloda in combination with oxaliplatin and avastin.
boolean
C0392920 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,3])
C0280780 (UMLS CUI [2])
C0724419 (UMLS CUI [3])
C0069717 (UMLS CUI [4])
C1135130 (UMLS CUI [5])
Major surgery Elapsed Time
Item
> 4 weeks must have elapsed from the time of major surgery
boolean
C0679637 (UMLS CUI [1,1])
C2826303 (UMLS CUI [1,2])
Minor Surgical Procedures Elapsed Time
Item
> 2 weeks must have elapsed from the time of minor surgery
boolean
C0038904 (UMLS CUI [1,1])
C2826303 (UMLS CUI [1,2])
Therapeutic radiology procedure Major Elapsed Time
Item
> 4 weeks must have elapsed from the time of major radiotherapy
boolean
C1522449 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C2826303 (UMLS CUI [1,3])
Organ function | Bone Marrow function
Item
normal organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Measurable Disease
Item
measurable disease be recist criteria
boolean
C1513041 (UMLS CUI [1])
Age
Item
older than 18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0-1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy > 12 weeks
boolean
C0023671 (UMLS CUI [1])
irinotecan | cetuximab | SU 11248
Item
previous treatment with irinotecan, cetuximab or su011248
boolean
C0123931 (UMLS CUI [1])
C0995188 (UMLS CUI [2])
C1176021 (UMLS CUI [3])
Angina, Unstable | Angina Pectoris Severe | Myocardial Infarction | Symptomatic congestive heart failure | Cerebrovascular accident | Transient Ischemic Attack
Item
any of the following within the 12 months prior to study drug administration: severe/unstable angina; myocardial infarction; symptomatic congestive heart failure; cerebrovascular accident; or transient ischemic attack.
boolean
C0002965 (UMLS CUI [1])
C0002962 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
C0742758 (UMLS CUI [4])
C0038454 (UMLS CUI [5])
C0007787 (UMLS CUI [6])
Metastatic malignant neoplasm to brain | Meningeal Carcinomatosis
Item
known brain metastases or carcinomatous meningitis
boolean
C0220650 (UMLS CUI [1])
C0220654 (UMLS CUI [2])
Illness Serious Uncontrolled | Mental disorder Serious Uncontrolled
Item
uncontrolled serious medical or psychiatric illness
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0205318 (UMLS CUI [2,3])
Hemorrhage CTCAE Grades
Item
nci ctcae grade 3 or greater hemorrhage within 4 weeks of starting study treatment
boolean
C0019080 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Uncontrolled hypertension
Item
uncontrolled hypertension
boolean
C1868885 (UMLS CUI [1])
Secondary Malignant Neoplasm | Basal cell carcinoma Treated | Squamous cell carcinoma of skin Treated | Prostate carcinoma Localized Prostate specific antigen normal | Carcinoma in situ of bladder Treated | Carcinoma in situ of uterine cervix Treated
Item
diagnosis of any secondary malignancies with the last 5 years, except for adequately treated basal cell carcinoma, squamous cell skin cancer, localized prostate cancer with a normal psa within the past 3 months, in situ bladder cancer, or in situ cervical cancer
boolean
C3266877 (UMLS CUI [1])
C0007117 (UMLS CUI [2,1])
C1522326 (UMLS CUI [2,2])
C0553723 (UMLS CUI [3,1])
C1522326 (UMLS CUI [3,2])
C0600139 (UMLS CUI [4,1])
C0392752 (UMLS CUI [4,2])
C0580554 (UMLS CUI [4,3])
C0154091 (UMLS CUI [5,1])
C1522326 (UMLS CUI [5,2])
C0851140 (UMLS CUI [6,1])
C1522326 (UMLS CUI [6,2])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Study Subject Participation Status
Item
concurrent treatment on another clinical trial
boolean
C2348568 (UMLS CUI [1])