Age
Item
18 years or older.
boolean
C0001779 (UMLS CUI [1])
Adenocarcinoma of large intestine unresectable TNM clinical staging | Adenocarcinoma of large intestine Advanced Local TNM clinical staging | Adenocarcinoma of large intestine metastatic TNM clinical staging | Adenocarcinoma of large intestine Amenable Curative Surgery | Adenocarcinoma of large intestine Amenable Therapeutic radiology procedure
Item
histologically confirmed, unresectable, locally advanced or metastatic colorectal adenocarcinoma (stage iii and iv), not amenable to curative surgery or radiotherapy.
boolean
C1319315 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C1319315 (UMLS CUI [2,1])
C0205179 (UMLS CUI [2,2])
C0205276 (UMLS CUI [2,3])
C3258246 (UMLS CUI [2,4])
C1319315 (UMLS CUI [3,1])
C1522484 (UMLS CUI [3,2])
C3258246 (UMLS CUI [3,3])
C1319315 (UMLS CUI [4,1])
C3900053 (UMLS CUI [4,2])
C1511562 (UMLS CUI [4,3])
C1319315 (UMLS CUI [5,1])
C3900053 (UMLS CUI [5,2])
C1522449 (UMLS CUI [5,3])
intolerance to oxaliplatin | intolerance to irinotecan | Toxic effect Post First line treatment | Oxaliplatin Toxic effect High risk of | Irinotecan Toxic effect High risk of
Item
intolerant of oxaliplatin and/or irinotecan, as demonstrated by unacceptable toxicity after a trial of these agents as first-line therapy, or in the opinion of the investigator, be judged at high risk for unacceptable toxicity to oxaliplatin and/or irinotecan,
boolean
C1744706 (UMLS CUI [1,1])
C0069717 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0123931 (UMLS CUI [2,2])
C0600688 (UMLS CUI [3,1])
C0687676 (UMLS CUI [3,2])
C1708063 (UMLS CUI [3,3])
C0069717 (UMLS CUI [4,1])
C0600688 (UMLS CUI [4,2])
C0332167 (UMLS CUI [4,3])
C0123931 (UMLS CUI [5,1])
C0600688 (UMLS CUI [5,2])
C0332167 (UMLS CUI [5,3])
Measurable Disease Quantity
Item
presence of at least 1 measurable lesion,
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Life Expectancy
Item
have a life expectancy of at least 4 months.
boolean
C0023671 (UMLS CUI [1])
Childbearing Potential Serum pregnancy test negative | Childbearing Potential Sexual Abstinence | Childbearing Potential Contraceptive methods
Item
women of childbearing potential, have a negative serum pregnancy test at screening and day 1 treatment and agree to practice abstinence or use an effective method of contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0430061 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0036899 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
CNS metastases
Item
central nervous system metastasis.
boolean
C0686377 (UMLS CUI [1])
Secondary malignant neoplasm of bone alone
Item
bony metastasis as the sole metastasis.
boolean
C0153690 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
First line Chemotherapy Colorectal Carcinoma
Item
received any prior first-line chemotherapy for colorectal cancer.
boolean
C1708063 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C0009402 (UMLS CUI [1,3])
Exposure to Davanat | Exposure to Avastin
Item
previously exposed to davanat® or avastin®.
boolean
C0332157 (UMLS CUI [1,1])
C1328211 (UMLS CUI [1,2])
C0332157 (UMLS CUI [2,1])
C1135130 (UMLS CUI [2,2])
HIV Infection | HIV Infection Suspected clinical
Item
known or clinically suspected infection with hiv.
boolean
C0019693 (UMLS CUI [1])
C0019693 (UMLS CUI [2,1])
C2732483 (UMLS CUI [2,2])
Study Subject Participation Status | Investigational New Drugs | Vaccines
Item
participated within 30 days or will participate concurrently in another investigational drug or vaccine study.
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C0042210 (UMLS CUI [3])
Substance Dependence
Item
history of drug or alcohol dependence in the past 3 years.
boolean
C0038580 (UMLS CUI [1])
Disease Serious Affecting patient safety | Disease Serious Protocol Compliance Limited | Disease Serious Interferes with research results | Mental disorders Serious Affecting patient safety | Mental disorders Serious Protocol Compliance Limited | Mental disorder Serious Interferes with research results
Item
other serious, non-malignant, significant, acute or chronic medical or psychiatric illness that in the judgment of the investigator could compromise subject safety, limit the subject's ability to complete the study, and/or compromise the objectives of the study.
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C1113679 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C0439801 (UMLS CUI [2,4])
C0012634 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C0521102 (UMLS CUI [3,3])
C0683954 (UMLS CUI [3,4])
C0004936 (UMLS CUI [4,1])
C0205404 (UMLS CUI [4,2])
C0392760 (UMLS CUI [4,3])
C1113679 (UMLS CUI [4,4])
C0004936 (UMLS CUI [5,1])
C0205404 (UMLS CUI [5,2])
C0525058 (UMLS CUI [5,3])
C0439801 (UMLS CUI [5,4])
C0004936 (UMLS CUI [6,1])
C0205404 (UMLS CUI [6,2])
C0521102 (UMLS CUI [6,3])
C0683954 (UMLS CUI [6,4])