Low-risk early stage breast cancer
Item
diagnosis of low-risk early stage breast cancer, meeting the following criteria:
boolean
C2986665 (UMLS CUI [1,1])
C3538919 (UMLS CUI [1,2])
Invasive adenocarcinoma
Item
invasive adenocarcinoma
boolean
C0853879 (UMLS CUI [1])
Invasive Lobular Breast Carcinoma
Item
no invasive carcinoma of classical lobular type
boolean
C0279565 (UMLS CUI [1])
Lymphovascular invasion
Item
no lymphovascular invasion
boolean
C1708790 (UMLS CUI [1])
Tumor size
Item
tumor size pathologically determined to be ≤ 3.0 cm in diameter (pt1-2) (< 3.1 cm maximum microscopic diameter of invasive component)
boolean
C0475440 (UMLS CUI [1])
Unifocal disease
Item
unifocal disease
boolean
C1710542 (UMLS CUI [1])
Grading
Item
grade i, ii, or iii disease
boolean
C0919553 (UMLS CUI [1])
Axillary lymph nodes
Item
axillary lymph nodes negative (pn0)
boolean
C0729594 (UMLS CUI [1])
Sentinel lymph node
Item
sentinel lymph node biopsy and isolated tumor cells < 0.2 mm allowed
boolean
C0796693 (UMLS CUI [1])
Breast-Conserving Surgery
Item
must have undergone breast conservation surgery with or without adjuvant systemic therapy
boolean
C0917927 (UMLS CUI [1])
Tumor margin status
Item
minimum microscopic margin of non-cancerous tissue ≥ 2 mm (excluding deep margin if this is at deep fascia)
boolean
C1269830 (UMLS CUI [1])
Recurrence Risk
Item
at low risk of local recurrence after radiotherapy (< 1% annual risk local recurrence)
boolean
C2986492 (UMLS CUI [1])
Mastectomy
Item
no prior mastectomy
boolean
C0024881 (UMLS CUI [1])
Hematogen metastases
Item
no blood-borne metastases
boolean
C1700301 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
Patient characteristics
Item
patient characteristics:
boolean
C0815172 (UMLS CUI [1])
Prior malignancy
Item
no prior malignancy except nonmelanoma skin cancer
boolean
C2735088 (UMLS CUI [1])
Concurrent therapy
Item
prior concurrent therapy:
boolean
C0009429 (UMLS CUI [1])
Disease characteristics
Item
see disease characteristics
boolean
C1705348 (UMLS CUI [1])
Endocrine therapy or chemotherapy
Item
no prior endocrine therapy or chemotherapy
boolean
C0279025 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
Neoadjuvant endocrine therapy
Item
neoadjuvant endocrine therapy allowed provided the tumour is < 3.0 cm and all other inclusion criteria are met
boolean
C0600558 (UMLS CUI [1,1])
C0279025 (UMLS CUI [1,2])
Primary endocrine therapy
Item
no primary endocrine therapy as a replacement for surgery
boolean
C1708063 (UMLS CUI [1,1])
C0279025 (UMLS CUI [1,2])
Concurrent chemoradiotherapy
Item
no concurrent chemoradiotherapy
boolean
C3178775 (UMLS CUI [1])