Gender | Colorectal cancer metastatic
Item
males and females with histologically confirmed metastatic colorectal cancer
boolean
C0079399 (UMLS CUI [1])
C0948380 (UMLS CUI [2])
Measurable Disease
Item
measurable disease according to response criteria for solid tumors (recist)
boolean
C1513041 (UMLS CUI [1])
Chemotherapy Regimen Quantity | Biological treatment Quantity
Item
at least 1 prior therapeutic regimen (chemotherapy or biologic)
boolean
C0392920 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1531518 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
ECOG performance status
Item
ecog performance status of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy ≥3 months
boolean
C0023671 (UMLS CUI [1])
Organ function | Bone Marrow function
Item
adequate organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Malignant Neoplasms
Item
no other malignancies within 5 years
boolean
C0006826 (UMLS CUI [1])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Therapeutic radiology procedure Bone Marrow Percentage | XL999
Item
radiation to ≥25% of bone marrow within 30 days of xl999 treatment
boolean
C1522449 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C1541529 (UMLS CUI [2])
cancer treatment Systemic | XL999
Item
treatment with systemic anticancer therapy within 30 days of xl999 treatment
boolean
C0920425 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C1541529 (UMLS CUI [2])
Adverse reaction to drug | Study Subject Recovered CTCAE Grades
Item
subject has not recovered to ≤ grade 1 or to within 10% of baseline from adverse events due to other medications administered >30 days prior to study enrollment
boolean
C0041755 (UMLS CUI [1])
C0681850 (UMLS CUI [2,1])
C0521108 (UMLS CUI [2,2])
C1516728 (UMLS CUI [2,3])
Metastatic malignant neoplasm to brain | Compression of spinal cord | Meningeal Carcinomatosis
Item
history of or known brain metastases, current spinal cord compression, or carcinomatous meningitis
boolean
C0220650 (UMLS CUI [1])
C0037926 (UMLS CUI [2])
C0220654 (UMLS CUI [3])
Illness Uncontrolled | Intercurrent disease
Item
uncontrolled and/or intercurrent illness
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0277557 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding females
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Infection
Item
known hiv
boolean
C0019693 (UMLS CUI [1])