Chronic Lymphocytic Leukemia untreated Indication of Therapeutic procedure | Chronic lymphocytic prolymphocytic leukemia syndrome untreated Indication of Therapeutic procedure | Small Lymphocytic Lymphoma untreated Indication of Therapeutic procedure | Symptoms Disease Related | Fever | Night sweats | Weight decreased | Fatigue Severe | advanced disease Rai Staging System | advanced disease Binet Staging System | Autoimmune hemolytic anemia Unresponsive to Treatment | Autoimmune thrombocytopenia Unresponsive to Treatment | HEPATOMEGALY MASSIVE | Hepatomegaly Progressive | splenomegaly massive | Splenomegaly Progressive | Lymphadenopathy massive | Lymphadenopathy Progressive | Recurrent infections | Lymphocyte Doubling Time Rapid
Item
1. untreated cll, cll/pll, or sll (small lymphocytic lymphoma) with indication for therapy (indications for therapy include at least one of the following: i) one or more disease-related symptoms [fever, night sweats, weight loss, pronounced fatigue]; ii) advanced stage disease (rai stage >/= 3 or binet stage c); iii) autoimmune anemia and/or thrombocytopenia that is unresponsive to other therapies; iv) massive or progressive hepatomegaly and/or splenomegaly and/or lymphadenopathy; iv) recurrent infections; v) rapid lymphocyte doubling time of < 6 months).
boolean
C0023434 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0392360 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C0349630 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C0392360 (UMLS CUI [2,3])
C0087111 (UMLS CUI [2,4])
C0855095 (UMLS CUI [3,1])
C0332155 (UMLS CUI [3,2])
C0392360 (UMLS CUI [3,3])
C0087111 (UMLS CUI [3,4])
C1457887 (UMLS CUI [4,1])
C0012634 (UMLS CUI [4,2])
C0439849 (UMLS CUI [4,3])
C0015967 (UMLS CUI [5])
C0028081 (UMLS CUI [6])
C1262477 (UMLS CUI [7])
C0015672 (UMLS CUI [8,1])
C0205082 (UMLS CUI [8,2])
C0679246 (UMLS CUI [9,1])
C1514715 (UMLS CUI [9,2])
C0679246 (UMLS CUI [10,1])
C1511118 (UMLS CUI [10,2])
C0002880 (UMLS CUI [11,1])
C0205269 (UMLS CUI [11,2])
C0242584 (UMLS CUI [12,1])
C0205269 (UMLS CUI [12,2])
C0744871 (UMLS CUI [13])
C0019209 (UMLS CUI [14,1])
C0205329 (UMLS CUI [14,2])
C0241231 (UMLS CUI [15])
C0038002 (UMLS CUI [16,1])
C0205329 (UMLS CUI [16,2])
C0235599 (UMLS CUI [17])
C0497156 (UMLS CUI [18,1])
C0205329 (UMLS CUI [18,2])
C0239998 (UMLS CUI [19])
C0024264 (UMLS CUI [20,1])
C2986483 (UMLS CUI [20,2])
C0456962 (UMLS CUI [20,3])
Age
Item
2. age < 70 years.
boolean
C0001779 (UMLS CUI [1])
Liver function | Serum total bilirubin measurement | Alanine aminotransferase measurement | Renal function | Creatinine measurement, serum | Renal dysfunction Due to Lymphocyte Infiltration | Liver Dysfunction Due to Lymphocyte Infiltration | Gilbert Disease
Item
3. adequate liver function (total bilirubin </= 2.5 mg/dl, sgpt </=4 x uln) and renal function (serum creatinine </= 2.0 mg/dl). patients with renal or liver dysfunction due to suspected organ infiltration by lymphocytes may be eligible after discussion with the principal investigator, but upper limits for creatinine even under these circumstances must be creatinine < 3mg/dl and bilirubin < 6 mg/dl. patients with gilbert's syndrome may be entered on study with bilirubin levels </= 4 mg/dl.
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0232804 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
C3279454 (UMLS CUI [6,1])
C0678226 (UMLS CUI [6,2])
C0024264 (UMLS CUI [6,3])
C0332448 (UMLS CUI [6,4])
C0086565 (UMLS CUI [7,1])
C0678226 (UMLS CUI [7,2])
C0024264 (UMLS CUI [7,3])
C0332448 (UMLS CUI [7,4])
C0017551 (UMLS CUI [8])
Beta-2-microglobulin measurement
Item
4. beta-2-microglobulin </= 4 mg/dl.
boolean
C0201910 (UMLS CUI [1])
ECOG performance status
Item
5. ecog performance status </= 2.
boolean
C1520224 (UMLS CUI [1])
Informed Consent
Item
6. signed informed consent in keeping with the policies of the hospital.
boolean
C0021430 (UMLS CUI [1])
Fertility Barrier method contraception | Latex condom | Vaginal contraceptive diaphragm | CERVICAL CAP FOR CONTRACEPTIVE USE | Childbearing Potential Serum pregnancy test negative | Childbearing Potential Urine pregnancy test negative | Postmenopausal state | Female Sterilization
Item
7. male and female patients who are fertile agree to use an effective barrier method of birth control (ie, latex condom, diaphragm, cervical cap, etc) to avoid pregnancy. female patients of childbearing potential (non-childbearing is defined as >/= 1 year postmenopausal or surgically sterilized) need a negative serum or urine pregnancy test within 14 days of study enrollment.
boolean
C0015895 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C3873750 (UMLS CUI [2])
C0042241 (UMLS CUI [3])
C0493327 (UMLS CUI [4])
C3831118 (UMLS CUI [5,1])
C0430061 (UMLS CUI [5,2])
C3831118 (UMLS CUI [6,1])
C0430057 (UMLS CUI [6,2])
C0232970 (UMLS CUI [7])
C0015787 (UMLS CUI [8])
Hepatitis B | Hepatitis B surface antigen positive | Hepatitis B e antigen positive | Anti-HBc IgM antibody positive | Hbv DNA Test Positive
Item
1. active hepatitis b (at least one of the following markers positive: hbsag, hbeag, igm anti-hbc, hbv dna).
boolean
C0019163 (UMLS CUI [1])
C0149709 (UMLS CUI [2])
C0392390 (UMLS CUI [3])
C1096146 (UMLS CUI [4])
C1256114 (UMLS CUI [5,1])
C1514241 (UMLS CUI [5,2])
Chemotherapy | Immunotherapy
Item
2. concurrent chemotherapy or immunotherapy.
boolean
C0392920 (UMLS CUI [1])
C0021083 (UMLS CUI [2])
Pregnancy
Item
3. pregnant patients.
boolean
C0032961 (UMLS CUI [1])
HIV Infection
Item
4. history of hiv
boolean
C0019693 (UMLS CUI [1])
CNS disorder Symptomatic
Item
5. symptomatic cns disease
boolean
C0007682 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Heart Disease Symptomatic New York Heart Association Classification | Left ventricular ejection fraction | Multiple gated acquisition scanning | Echocardiography
Item
6. symptomatic heart disease (nyha class >/= 3) or lv ejection fraction < 40% (by muga or echocardiogram)
boolean
C0018799 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1275491 (UMLS CUI [1,3])
C0428772 (UMLS CUI [2])
C0521317 (UMLS CUI [3])
C0013516 (UMLS CUI [4])