Age
Item
1. male or female 50 years of age or greater.
boolean
C0001779 (UMLS CUI [1])
Systolic hypertension | Systolic Pressure | Diastolic blood pressure | Pulse pressure increased
Item
2. diagnosed with systolic hypertension (systolic blood pressure >140 mm hg and (less than or equal to) 200 mm hg, and a diastolic blood pressure (less than or equal to) 95 mm hg) and elevated pulse pressure (systolic blood pressure [sbp] minus diastolic blood pressure [dbp] greater than 60 mm hg).
boolean
C0221155 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
C0855323 (UMLS CUI [4])
normal left ventricular function | Cardiac ejection fraction
Item
3. normal left ventricular function (ejection fraction > 55%) at baseline (visit 3).
boolean
C1532664 (UMLS CUI [1])
C0232174 (UMLS CUI [2])
brachial artery Dilatation
Item
4. brachial artery must be able to be visualized for fmd and ppmv determinations.
boolean
C1278940 (UMLS CUI [1,1])
C1322279 (UMLS CUI [1,2])
Able to ride a bicycle Exercise Related
Item
5. able to perform bicycle exercise.
boolean
C0577366 (UMLS CUI [1,1])
C0015259 (UMLS CUI [1,2])
C0439849 (UMLS CUI [1,3])
Informed Consent
Item
6. able to read, understand and sign the informed consent after the nature of the study has been explained.
boolean
C0021430 (UMLS CUI [1])
Sexually active Contraceptive methods | Female Sterilization | Postmenopausal state | Gender Serum pregnancy test negative
Item
7. if sexually active, the subject agrees to use reliable contraception while participating in this study. if a woman, is surgically sterilized or post-menopausal, or has a negative serum pregnancy test.
boolean
C0241028 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0015787 (UMLS CUI [2])
C0232970 (UMLS CUI [3])
C0079399 (UMLS CUI [4,1])
C0430061 (UMLS CUI [4,2])
Aortic Stenosis | Coronary Artery Disease | Myocardial Infarction | Cerebrovascular accident | Peripheral Vascular Diseases
Item
1. aortic stenosis, prior known coronary artery disease (including myocardial infarction), cerebrovascular accident, or peripheral vascular disease.
boolean
C0003507 (UMLS CUI [1])
C1956346 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0038454 (UMLS CUI [4])
C0085096 (UMLS CUI [5])
Uncontrolled hypertension | Systolic Pressure | Diastolic blood pressure
Item
2. uncontrolled hypertension (sbp > 200/dbp > 95 mm hg).
boolean
C1868885 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
Atrial Fibrillation | Diabetes Mellitus insulin treatment | Chronic lung disease
Item
3. atrial fibrillation, diabetes mellitus treated with insulin, or chronic lung disease.
boolean
C0004238 (UMLS CUI [1])
C0011849 (UMLS CUI [2,1])
C0745343 (UMLS CUI [2,2])
C0746102 (UMLS CUI [3])
Condition Excludes Clinical Trial Completion
Item
4. any additional condition(s) which, in the opinion of the investigator, would prohibit the subject from completing the study, or not be in the best interest of the subject.
boolean
C0348080 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0008976 (UMLS CUI [1,3])
C0205197 (UMLS CUI [1,4])
Nitrates | Antihypertensive Agents Change
Item
5. treatment with nitrates, or a change in antihypertensive medications within the last 1 month.
boolean
C0028125 (UMLS CUI [1])
C0003364 (UMLS CUI [2,1])
C0392747 (UMLS CUI [2,2])
Investigational New Drugs
Item
6. treatment with any investigational drug within 1 month prior to study drug administration.
boolean
C0013230 (UMLS CUI [1])
Exposure to alagebrium
Item
7. previous exposure to alagebrium.
boolean
C0332157 (UMLS CUI [1,1])
C0913630 (UMLS CUI [1,2])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
8. ast (sgot) or alt (sgpt) > 2x normal limit.
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Creatinine measurement, serum
Item
9. serum creatinine > 2.0 mg/dl.
boolean
C0201976 (UMLS CUI [1])
Tobacco use
Item
10. cigar/cigarette smoking.
boolean
C0543414 (UMLS CUI [1])
User of smokeless tobacco | Nicotine Dependence | Caffeine dependence | Alcoholic Intoxication, Chronic | Antioxidants Use
Item
11. necessity to use smokeless tobacco or nicotine-containing products, or to consume caffeine, alcohol, or antioxidants starting at midnight prior to study clinic visits. note: water is allowed ad libitim.
boolean
C4075678 (UMLS CUI [1])
C0028043 (UMLS CUI [2])
C1386553 (UMLS CUI [3])
C0001973 (UMLS CUI [4])
C0003402 (UMLS CUI [5,1])
C1524063 (UMLS CUI [5,2])
Drug screen positive
Item
12. positive drug screen.
boolean
C0743295 (UMLS CUI [1])