Non-Small Cell Lung Carcinoma Pleural effusion TNM clinical staging | Non-Small Cell Lung Carcinoma TNM clinical staging | Conventional Treatment Cure Unsuccessful | smoking cigarettes: ____ pack-years history | Non-smoker
Item
pathologic diagnosis of nsclc and current stage iiib (with pleural effusion) or iv, not curable with conventional therapy. for arm c, less than or equal to 20 pack-years smoking history and current non smoker. a pack year = number of packs of cigarettes smoked per day x years smoked.
boolean
C0007131 (UMLS CUI [1,1])
C0032227 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C0007131 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
C2945704 (UMLS CUI [3,1])
C1880198 (UMLS CUI [3,2])
C1272705 (UMLS CUI [3,3])
C2230126 (UMLS CUI [4])
C0337672 (UMLS CUI [5])
Tarceva | Iressa | Disease Progression
Item
progression following at least 12 weeks of treatment with tarceva or iressa. (arms a and b only)
boolean
C1135136 (UMLS CUI [1])
C0919281 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
ECOG performance status
Item
ecog (eastern cooperative oncology group) performance status of 0, 1, or 2 (not declining within past 2 weeks).
boolean
C1520224 (UMLS CUI [1])
Tumor tissue sample Available Analysis
Item
tumor sample available and adequate for analysis.
boolean
C0475358 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
C0002778 (UMLS CUI [1,3])
Target Lesion Measurable
Item
at least one measurable target lesion.
boolean
C2986546 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
Cardiac function | Renal function | Liver function
Item
adequate cardiac, kidney, and liver function
boolean
C0232164 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
Blood Cell Count
Item
adequate blood counts
boolean
C0005771 (UMLS CUI [1])
Cytotoxic Chemotherapy Quantity Recurrent disease | Cytotoxic Chemotherapy Quantity Neoplasm Metastasis
Item
more than 3 prior cytotoxic chemotherapy treatments for relapsed or metastatic disease.
boolean
C0677881 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0277556 (UMLS CUI [1,3])
C0677881 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0027627 (UMLS CUI [2,3])
Heart Disease Significant | Cardiac dysfunction
Item
significant cardiac disease or dysfunction.
boolean
C0018799 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C3277906 (UMLS CUI [2])
Anthracyclines Cumulative Dose Amount
Item
prior treatment with anthracyclines with cumulative dose of >400 mg/m^2.
boolean
C0282564 (UMLS CUI [1,1])
C2986497 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
CNS metastases Symptoms Clinical | CNS metastases Growth Progressive
Item
active central nervous system metastases, as indicated by clinical symptoms and/or progressive growth.
boolean
C0686377 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0686377 (UMLS CUI [2,1])
C0220844 (UMLS CUI [2,2])
C0205329 (UMLS CUI [2,3])
Tarceva | Iressa
Item
use of tarceva or iressa within 14 days of treatment day 1 (arms a and b only).
boolean
C1135136 (UMLS CUI [1])
C0919281 (UMLS CUI [2])
major surgery | Chemotherapy | Therapeutic radiology procedure | Investigational New Drugs | cancer treatment
Item
major surgery, chemotherapy, radiotherapy, investigational drugs, or other cancer therapy within 3 weeks of treatment day 1.
boolean
C0679637 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
C0013230 (UMLS CUI [4])
C0920425 (UMLS CUI [5])
Gastrointestinal Disease chronic significant | Gastrointestinal Disease Recent | Diarrhea symptoms major
Item
significant chronic or recent acute gastrointestinal disorder with diarrhea as a major symptom.
boolean
C0017178 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0750502 (UMLS CUI [1,3])
C0017178 (UMLS CUI [2,1])
C0332185 (UMLS CUI [2,2])
C0011991 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
Able to swallow HKI 272 capsules | HKI 272 capsules Swallowing Unwilling
Item
inability or unwillingness to swallow hki-272 capsules.
boolean
C2712086 (UMLS CUI [1,1])
C1454298 (UMLS CUI [1,2])
C0006935 (UMLS CUI [1,3])
C1454298 (UMLS CUI [2,1])
C0006935 (UMLS CUI [2,2])
C0740170 (UMLS CUI [2,3])
C0558080 (UMLS CUI [2,4])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])