Polycystic Kidney, Autosomal Dominant | Age
Item
male or female adpkd patient between 18 and 40 years of age
boolean
C0085413 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Glomerular Filtration Rate
Item
measured gfr higher than 70 ml/min 1.73m2
boolean
C0017654 (UMLS CUI [1])
Kidney Volume Progressive
Item
documented kidney volume progression
boolean
C2827452 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
Informed Consent
Item
informed consent
boolean
C0021430 (UMLS CUI [1])
Childbearing Potential Planned Pregnancy | Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Unwilling
Item
female of childbearing potential who is planning to become pregnant, who is pregnant and/or lactating, who is unwilling to use effective means of contraception
boolean
C3831118 (UMLS CUI [1,1])
C0032992 (UMLS CUI [1,2])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C3831118 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
C0558080 (UMLS CUI [4,3])
Elevated liver enzymes
Item
increased liver enzymes (2-fold above normal values)
boolean
C0235996 (UMLS CUI [1])
Hypercholesterolemia Uncontrolled | Fasting cholesterol level | Hypertriglyceridemia Uncontrolled | Lipid-lowering therapy
Item
hypercholesterolemia (fasting cholesterol > 8 mmol/l) or hypertriglyceridaemia (> 5 mmol/l) not controlled by lipid lowering therapy
boolean
C0020443 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C1282513 (UMLS CUI [2])
C0020557 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0585943 (UMLS CUI [4])
Agranulocytosis | White Blood Cell Count procedure | Thrombocytopenia | Platelet Count measurement
Item
granulocytopenia (white blood cell < 3,000/mm3) or thrombocytopenia (platelets < 100,000/mm3),
boolean
C0001824 (UMLS CUI [1])
C0023508 (UMLS CUI [2])
C0040034 (UMLS CUI [3])
C0032181 (UMLS CUI [4])
Hepatitis B | Hepatitis C | HIV Infection
Item
infection with hepatitis b or c, hiv
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0019693 (UMLS CUI [3])
Malignant Neoplasms
Item
any past or present malignancy
boolean
C0006826 (UMLS CUI [1])
Mental disorder Interferes with Protocol Compliance
Item
mental illness that interfere with the patient ability to comply with the protocol
boolean
C0004936 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
Substance Use Disorders
Item
drug or alcohol abuse within one year of baseline
boolean
C0038586 (UMLS CUI [1])
Cytochrome P450 3A4 Inhibitor Strong | P-Glycoprotein Similarity | Voriconazole | Ketoconazole | Diltiazem | Verapamil | Erythromycin
Item
co-medication with strong inhibitor of cyp3a4 and or p-gp like voriconazole, ketoconazole, diltiazem, verapamil, erythromycin
boolean
C3830624 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C0242643 (UMLS CUI [2,1])
C2348205 (UMLS CUI [2,2])
C0393080 (UMLS CUI [3])
C0022625 (UMLS CUI [4])
C0012373 (UMLS CUI [5])
C0042523 (UMLS CUI [6])
C0014806 (UMLS CUI [7])
Cytochrome P-450 CYP3A4 Strong | P-Glycoprotein Inducer Similarity | Rifampin
Item
co-medication with strong cyp3a4 and or p-gp inductor like rifampicin
boolean
C3714798 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C0242643 (UMLS CUI [2,1])
C3898767 (UMLS CUI [2,2])
C2348205 (UMLS CUI [2,3])
C0035608 (UMLS CUI [3])
Macrolide allergy | Hypersensitivity Rapamune
Item
known hypersensitivity to macrolides or rapamune
boolean
C0571383 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0813828 (UMLS CUI [2,2])