Diffuse Large B-Cell Lymphoma CD20 antigen positive
Item
patient with histologically proven cd20+ diffuse large b cell lymphoma (who classification).
boolean
C0079744 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
Age | Transplantation eligibility
Item
age >18 and < 61 years, eligible for transplant.
boolean
C0001779 (UMLS CUI [1])
C0040732 (UMLS CUI [2,1])
C1698001 (UMLS CUI [2,2])
Patient untreated
Item
patient not previously treated.
boolean
C0030705 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
International Prognostic Index Age Adjusted | Prognostic Factor Quantity
Item
with at least two prognostic factors of the aa-ipi.
boolean
C1512894 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0456081 (UMLS CUI [1,3])
C1514474 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Life Expectancy Minimum
Item
with a minimum life expectancy of 3 months.
boolean
C0023671 (UMLS CUI [1,1])
C1524031 (UMLS CUI [1,2])
Creatinine measurement, serum | Serum total bilirubin measurement | Transaminases increased | Abnormality Lymphoma Related
Item
creatinin level ≤ 150mmol/l, total bilirubin level 30mmol/l and transaminases 2.5 maximum normal level, unless abnormalities are related to the lymphoma.
boolean
C0201976 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0438717 (UMLS CUI [3])
C1704258 (UMLS CUI [4,1])
C0024299 (UMLS CUI [4,2])
C0439849 (UMLS CUI [4,3])
Absolute neutrophil count | Platelet Count measurement | Bone marrow infiltration
Item
neutrophils > 1.5 g/l and platelets > 100 g/l, unless if patient has a bone marrow infiltration.
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C3854434 (UMLS CUI [3])
HIV test negative | Hepatitis B Virus Serology negative | Hepatitis C virus Serology negative | Vaccination
Item
negative hiv, hbv and hcv serologies 4 weeks (except after vaccination).
boolean
C0854048 (UMLS CUI [1])
C0019169 (UMLS CUI [2,1])
C0919674 (UMLS CUI [2,2])
C0220847 (UMLS CUI [3,1])
C0919674 (UMLS CUI [3,2])
C0042196 (UMLS CUI [4])
Informed Consent
Item
having previously signed a written informed consent.
boolean
C0021430 (UMLS CUI [1])
Lymphoma Histologic type
Item
any other histological type of lymphoma.
boolean
C0024299 (UMLS CUI [1,1])
C0449574 (UMLS CUI [1,2])
Indolent lymphoma Treated | Indolent lymphoma untreated
Item
any history of treated or non-treated indolent lymphoma.
boolean
C1334170 (UMLS CUI [1,1])
C1522326 (UMLS CUI [1,2])
C1334170 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
Central Nervous System Involvement Lymphoma | Meningeal Lymphoma
Item
central nervous system or meningeal involvement by lymphoma.
boolean
C4050309 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
C2213017 (UMLS CUI [2])
Medical contraindication Antineoplastic Agents
Item
contra-indication to any drug contained in the chemotherapy regimens.
boolean
C1301624 (UMLS CUI [1,1])
C0003392 (UMLS CUI [1,2])
Malignant Neoplasms | Skin carcinoma | Carcinoma in situ of uterine cervix
Item
any history of cancer during the last 5 years, with the exception of non-melanoma skin tumors or stage 0 (in situ) cervical carcinoma.
boolean
C0006826 (UMLS CUI [1])
C0699893 (UMLS CUI [2])
C0851140 (UMLS CUI [3])
Disease Serious
Item
any serious active disease (according to the investigator’s decision).
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Investigational New Drugs | Chemotherapy cycle Ordinal number
Item
treatment with any investigational drug within 30 days before planned first cycle of chemotherapy and during the study.
boolean
C0013230 (UMLS CUI [1])
C1302181 (UMLS CUI [2,1])
C0439080 (UMLS CUI [2,2])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Inadequate
Item
pregnant or lactating women or women of childbearing potential not currently practicing an adequate method of contraception.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0205412 (UMLS CUI [3,3])
Patient adult Guardianship
Item
adult patient under tutelage.
boolean
C0030705 (UMLS CUI [1,1])
C0001675 (UMLS CUI [1,2])
C0870627 (UMLS CUI [1,3])